Neurodegeneration News and Research

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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.

Aggregation propensity, amyloid peptide toxicity and Alzheimer disease

Cells have evolved multiple mechanisms to ensure proper folding, but a number of molecular and biophysical events - such as changes in pH or temperature, mutations, and oxidation - can disrupt a protein's native shape.

31 Oct 2007

Scientists discover new causes for neurodegeneration

Diseases that cause neurons to break-down, such as Alzheimer's, Multiple Sclerosis and Creutzfeldt-Jakob disease (Mad Cow Disease), continue to be elusive to scientists and resistant to treatments.

25 Oct 2007

The accumulation of sugar in neurons may explain the origin of several neurodegenerative diseases

A phenomenon considered healthy for cells, such as the accumulation of long chains of glucose (glycogen), which tissues store for energy purposes, is harmful for neurons.

22 Oct 2007

Benefits of exercise on the aging brain

Bradley Hatfield, professor in the University of Maryland, College Park, School of Public Health, uses high tech brain imaging to study the benefits of exercise on the aging brain.

15 Oct 2007

Discovery of new pathway causing cell death related to frontotemporal dementia and ALS

Scientists have discovered a link between a mutated gene and a protein found in dead brain cells of people who suffer from a form of dementia and other neurological disorders.

27 Sep 2007

Two genes in mammalian cells act as gatekeepers for cellular longevity

In everything from yeast to primates, a significant decrease in calories can extend lifespan by as much as one-third. But getting under the hood of the molecular machinery that drives this longevity has remained elusive.

21 Sep 2007

Heat shock proteins are co-opted for cancer

A Jekyll-Hyde mechanism that both protects healthy cells and enables cancer cells could be the basis for new cancer-fighting drugs.

21 Sep 2007

Cell-surface sugar defects may trigger nerve damage in multiple sclerosis patients

Defects on cell-surface sugars may promote the short-term inflammation and long-term neurodegeneration that occurs in the central nervous system of multiple sclerosis patients, according to University of California, Irvine researchers.

21 Sep 2007

Heat shock proteins are co-opted for cancer

A Jekyll-Hyde mechanism that both protects healthy cells and enables cancer cells could be the basis for new cancer-fighting drugs.

20 Sep 2007

Cell death in sparrow brains may provide clues in age-related human diseases

A remarkable change takes place in the brains of tiny songbirds every year, and some day the mechanism controlling that change may help researchers develop treatments for age-related degenerative diseases of the brain such as Parkinson's and dementia.

18 Sep 2007

Rochester receives $1.2 million to battle rare childhood disease

"For an orphan disease like Batten, which has such a clear-cut course of deterioration and no present cure, this grant is transformative both for these families and for us, as clinicians and researchers."

12 Sep 2007

3D fruit fly images to benefit brain research

The fragile head and brain of a fly are not easy things to examine but MRC scientists have figured out how to make it a little simpler. And they hope their research will shed light on human disease.

5 Sep 2007

HIV protein both causes brain injury and prevents its repair

New evidence reported in the August issue of Cell Stem Cell, a publication of Cell Press, offers a novel perspective on how the HIV/AIDS virus leads to learning and memory deficits, a condition known as HIV-associated dementia.

17 Aug 2007

New insight into fragile X tremor/ataxia syndrome

Researchers have reported new insight into the pathology underlying a recently identified neurological disorder that strikes middle-aged adults that is caused by alterations in the same gene that causes fragile X syndrome.

17 Aug 2007

The future of Alzheimer's disease research

Imagine the day when a routine visit to the family doctor includes a simple blood test to predict the risk for developing Alzheimer's disease (AD).

26 Jul 2007

RNA essential for survival of mature neurons

There are lots of things that brain cells need to survive. Add to that list microRNAs.

19 Jul 2007

Research on proteases and pathological processes

A research group of the UAB Institute of Biotechnology and Biomedicine and the UAB Department of Biochemistry and Molecular Biology, directed by Francesc Xavier Aviles, is the coordinator of a European project aimed at studying proteases with fluorescent molecules that allow their monitoring in healthy and pathological situations.

18 Jul 2007

UAB receives grants to investigate novel approaches to treat Parkinson's disease

The Michael J. Fox Foundation (MJFF) has awarded two research grants to UAB (University of Alabama at Birmingham) researchers to investigate novel approaches to treat Parkinson's disease.

13 Jul 2007

Early exposure to iron and later exposure to herbicide paraquat may accelerate age-related neurodegeneration

Exposure to iron during the first weeks of life in combination with exposure later in life to a common herbicide may contribute to the subsequent degeneration of brain cells associated with the onset of Parkinson's disease (PD), according to a new study in mice.

28 Jun 2007

Role of environmental factors in the development of Parkinson's disease

Scientists at the Buck Institute for Age Research have shown that combining two environmental toxic substances accelerated age-related degeneration in neurons associated with Parkinson's disease (PD) in mice.

27 Jun 2007