Neurodegenerative Diseases News and Research

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UC Berkeley professor wins Young Investigator Award by STEM CELLS journal

Dr Sanjay Kumar, MD, PhD has been named the winner of the Young Investigator Award by the journal STEM CELLS for leading research into the microenvironmental regulation of neural stem cells. The $10,000 prize is awarded annually to a young scientist whose paper has been judged to be of worldwide significance by a global jury.

5 Dec 2012

HDAC6 enzyme could be possible target for therapies against Alzheimer's

Scientists from the DZNE sites in G-ttingen and Bonn, the UMG as well as from the US participated in this basic research project on Alzheimer's disease. The study is published in "EMBO Molecular Medicine".

30 Nov 2012

Scientists identify two genes involved in establishing neuronal circuits required for breathing

Scientists at NYU Langone Medical Center have identified two genes involved in establishing the neuronal circuits required for breathing. They report their findings in a study published in the December issue of Nature Neuroscience.

30 Nov 2012

Specific combination of two pharmaceutical substances show promise against multiple sclerosis

A new substance class for the treatment of multiple sclerosis and other neurodegenerative diseases now promises increased efficacy paired with fewer side effects. To achieve this, a team of scientists under the leadership of Prof. Gunter Fischer and Dr. Frank Striggow have combined two already approved pharmaceutical substances with each other using a chemical linker structure.

27 Nov 2012

New way to protect neurons that express mutant huntingtin proteins

By using a model, researchers at the University of Montreal have identified and "switched off" a chemical chain that causes neurodegenerative diseases such as Huntington's disease, amyotrophic lateral sclerosis and dementia. The findings could one day be of particular therapeutic benefit to Huntington's disease patients. "We've identified a new way to protect neurons that express mutant huntingtin proteins," explained Dr. Alex Parker of the University of Montreal's Department of Pathology and Cell Biology and its affiliated CRCHUM Research Centre.

27 Nov 2012

Accera commences clinical efficacy trial of AC-1204 for mild-to-moderate Alzheimer's disease

Accera, Inc., a privately-held, commercial-stage, healthcare company focused on the discovery and development of innovative clinical applications to address acute and chronic neurodegenerative diseases, announced today the initiation of a clinical efficacy trial examining the effects of AC-1204 in patients with mild-to-moderate Alzheimer's disease (AD).

26 Nov 2012

Obesity and oxidative stress: an interview with Dr Elizabeth New

Even though oxygen is essential for us to live, it can react with other compounds in the body to produce molecules called free radicals, which are highly reactive and damaging.

22 Nov 2012

Scientists discover telomerase as cause of chronic inflammation in human cancers

A*STAR scientists have identified the enzyme, telomerase, as a cause of chronic inflammation in human cancers. Chronic inflammation is now recognized as a key underlying cause for the development of many human cancers, autoimmune disorders, neurodegenerative diseases, and metabolic diseases such as diabetes.

22 Nov 2012

Heidelberg researchers uncover function of specific molecular chaperones

Clumped proteins can be dissolved with the aid of cellular repair systems - a process of critical importance for cell survival especially under conditions of stress. Heidelberg researchers have now decrypted the fundamental mechanism for dissolving protein aggregates that involves specific molecular chaperones.

22 Nov 2012

UNSW-developed nanoparticle could improve effectiveness of chemotherapy for neuroblastoma

In a world-first, researchers from the Australian Centre for Nanomedicine at the University of New South Wales (UNSW) in Sydney have developed a nanoparticle that could improve the effectiveness of chemotherapy for neuroblastoma by a factor of five.

21 Nov 2012

Study: 2-PMPA improves cognition in mice with MS

Johns Hopkins researchers report the successful use of a form of MRI to identify what appears to be a key biochemical marker for cognitive impairment in the brains of people with multiple sclerosis (MS). In follow-up experiments on mice with a rodent form of MS, researchers were able to use an experimental compound to manipulate that same marker and dramatically improve learning and memory.

21 Nov 2012

Study shows how Parkinson's spreads and leads to nerve cell death

Understanding how any disease progresses is one of the first and most important steps towards finding treatments to stop it. This has been the case for such brain-degenerating conditions as Alzheimer's disease. Now, after several years of incremental study, researchers at the Perelman School of Medicine, University of Pennsylvania have been able to piece together important steps in how Parkinson's disease (PD) spreads from cell to cell and leads to nerve cell death.

17 Nov 2012

Oxytocin regulates social distance between women and men

Flirting brings women and men closer. But the "social distance" ensures that they will keep a certain spatial distance from each other. Researchers under the leadership of the University of Bonn studied whether this distance can be diminished by the so-called love hormone, oxytocin.

16 Nov 2012

Scientists discover link between mutation in immune system gene and Alzheimer's disease

An international research team including scientists from the University of Toronto's Faculty of Medicine has discovered a link between a mutation in an immune system gene and Alzheimer's disease.

15 Nov 2012

Dopamine improves long-term memory

The feel-good hormone dopamine improves long-term memory. This is the finding of a team lead by Emrah D-zel, neuroscientist at the German Center for Neurodegenerative Diseases and the University of Magdeburg.

9 Nov 2012

UC Irvine researchers create new stem cell-derived cell type for treatment of Alzheimer's

UC Irvine researchers have created a new stem cell-derived cell type with unique promise for treating neurodegenerative diseases such as Alzheimer's.

8 Nov 2012

XJB-5-131 compound suppresses symptoms of Huntington's in mice

There's new hope in the fight against Huntington's disease. A group of researchers that includes scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

2 Nov 2012

PET scans allow scientists to study link between caffeine and neurodegenerative disorders

Molecular imaging with positron emission tomography (PET) has enabled scientists for the first time to visualize binding sites of caffeine in the living human brain to explore possible positive and negative effects of caffeine consumption.

2 Nov 2012

Top-line results from Neuraltus’ NP001 Phase 2 study on amyotrophic lateral sclerosis

Neuraltus Pharmaceuticals, a private biopharmaceutical company developing novel therapies for rare neurological disorders, announced today top-line results from the Company's Phase 2 clinical study of NP001 in patients with Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's disease).

30 Oct 2012

STAT3 transcription factor remains in the axon of nerve cells to help prevent neurodegeneration

A study in The Journal of Cell Biology shows how a transcription factor called STAT3 remains in the axon of nerve cells to help prevent neurodegeneration. The findings could pave the way for future drug therapies to slow nerve damage in patients with neurodegenerative diseases.

30 Oct 2012

Neurodegenerative Diseases News and Research

UC Berkeley professor wins Young Investigator Award by STEM CELLS journal

HDAC6 enzyme could be possible target for therapies against Alzheimer's

Scientists identify two genes involved in establishing neuronal circuits required for breathing

Specific combination of two pharmaceutical substances show promise against multiple sclerosis

New way to protect neurons that express mutant huntingtin proteins

Accera commences clinical efficacy trial of AC-1204 for mild-to-moderate Alzheimer's disease

Obesity and oxidative stress: an interview with Dr Elizabeth New

Scientists discover telomerase as cause of chronic inflammation in human cancers

Heidelberg researchers uncover function of specific molecular chaperones

UNSW-developed nanoparticle could improve effectiveness of chemotherapy for neuroblastoma

Study: 2-PMPA improves cognition in mice with MS

Study shows how Parkinson's spreads and leads to nerve cell death

Oxytocin regulates social distance between women and men

Scientists discover link between mutation in immune system gene and Alzheimer's disease

Dopamine improves long-term memory

UC Irvine researchers create new stem cell-derived cell type for treatment of Alzheimer's

XJB-5-131 compound suppresses symptoms of Huntington's in mice

PET scans allow scientists to study link between caffeine and neurodegenerative disorders

Top-line results from Neuraltus’ NP001 Phase 2 study on amyotrophic lateral sclerosis

STAT3 transcription factor remains in the axon of nerve cells to help prevent neurodegeneration

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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