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Better understanding of olfactory system

Duke University Medical Center researchers have discovered how the brain creates a scent symphony from signals sent by the nose.

18 Jun 2006

Altered activity in receptor pair points to further complexity in schizophrenia pathology

Researchers at the University of Pennsylvania School of Medicine, in collaboration with scientists at the City University of New York, have identified a striking dysregulation in neuronal receptor activity in the postmortem brain tissue from patients with schizophrenia.

18 Jun 2006

Central nervous system can sometimes send out signals that invite hostile immune system attacks

It may sound like a case of blame the victim, but researchers at Washington University School of Medicine in St. Louis have shown that cells in the central nervous system can sometimes send out signals that invite hostile immune system attacks.

18 Jun 2006

New roles for growth factors

During embryonic development, nerve cells hesitantly extend tentacle-like protrusions called axons that sniff their way through a labyrinth of attractive and repulsive chemical cues that guide them to their target.

18 Jun 2006

Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors

Understanding what makes people crave the high of nicotine is a key to developing treatment for this highly addictive drug.

14 Jun 2006

Broca's area and the hierarchical organization of human behavior

Researchers have discovered that Broca's area in the brain - best known as the region that evolved to manage speech production - is a major "executive" center in the brain for organizing hierarchies of behaviors.

14 Jun 2006

Scientists reveal two paths of neurodegeneration

Wiring the developing brain is like creating a topiary garden. Shrubs don't automatically assume the shape of ornamental elephants, and neither do immature nerve cells immediately recognize the "right" target cell.

14 Jun 2006

Stem cell breakthrough

Researchers at The Hospital for Sick Children (SickKids) and the University of Calgary have found that stem cells derived from adult skin can create neural cell types that can be transplanted into and function in mouse models of disease.

14 Jun 2006

Mechanism for neurodenegerative diseases linked to transport proteins

Hampering the transport of proteins within cells may underlie several adult-onset neurodegenerative diseases, such as Huntington's, ALS and Kennedy disease. Understanding how this cell transport is blocked in these diseases may offer targets for future therapy.

9 Jun 2006

Resolution of uncertainty in prefrontal cortex

Whether finding your way through an unfamiliar neighborhood to a friend's house or deciding on a political candidate, your brain is adept at adapting.

9 Jun 2006

Protein called Elk-1appears to play role in neurodegeneration and schizophrenia

Pprotein called Elk-1 interacts with mitochondria, the energy storehouse of a cell, suggesting that this protein - typically active in the nucleus - could play a role in cell death and mitochondria-related diseases such as neurodegeneration and schizophrenia.

9 Jun 2006

"Mechanistic basis for understanding why we treat symptoms"

In the 1990s, the notion of "six degrees of separation" emphasized human linkages that connected people around the world.

9 Jun 2006

Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose

One of the body's basic survival mechanisms is the neural machinery that triggers the hungry brain to the alertness needed for seeking food.

From The University of Manchester 7 Jun 2006

A core system for the implementation of task sets

Scientists have used data from scans of 183 subjects to identify brain areas that consistently become active in a variety of cognitive tasks, such as reading, learning a rhythm or analyzing a picture.

7 Jun 2006

Midbrain, striatal and amygdalar dopaminergic dysfunction in ADHD

The brain's dopamine system, which has long been associated with reward learning and reward-related behavior, works differently in treated and untreated attention deficit hyperactivity disorder (ADHD) individuals.

7 Jun 2006

TB drug may cure Parkinson-type symptoms of manganese intoxication

Researchers have discovered that a drug used to treat tuberculosis apparently cures patients of a Parkinson's-like illness suffered by thousands of mineworkers, welders and others exposed to high levels of the metal manganese.

7 Jun 2006

Activity in the lateral prefrontal cortex reflects multiple steps of future events in action plans

Studies in which monkeys were asked to manipulate computer cursors for fruit juice rewards have revealed that the brain's "executive" center plans behaviors not by specifying movements required for given actions, but rather the events that will result from those actions.

6 Jun 2006

Novel research points to promising relief target for chronic pain

By some accounts, chronic pain affects nearly 100 million Americans from such varied causes as arthritis, sciatica, cancer, diabetes. Most forms of pain result from identifiable causes which serve the "good" purpose in warning of a real physical problem that needs attention, or rest.

6 Jun 2006

Researchers show that different forms of amyloid beta lead to neural damage in different ways

Researchers at UC Irvine have shown that different forms of amyloid beta lead to neural damage in different ways, leading to an increasingly complex view of amyloid toxicity in the Alzheimer brain.

6 Jun 2006