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Important discovery could lead to new treatments for obesity and related diseases

Researchers at the University of East Anglia and the University of Cambridge have made an important discovery in the race to find treatments for obesity and related diseases, such as diabetes.

31 May 2023

Obesity strikes below the belt: Study reveals link between obesity and male infertility

The influence of obesity on male fertility is still under debate. In the present investigation, researchers scrutinized semen samples from both obese individuals and those of normal weight. The aim was to explore the relationship between obesity, the length of sperm telomeres, levels of mRNA associated with autophagy, and diverse semen characteristics.

29 May 2023

Genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene shaped by exogenous exposures

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, "Exogenous exposures shape genetic predisposition to lipids, Alzheimer's, and coronary heart disease in the MLXIPL gene locus."

25 May 2023

COVID-19 'bites the apple': Abdominal obesity ignites cytokine storm

Abdominal obesity increases the risk of severe COVID-19 and mortality due to heightened inflammatory responses, according to a study on Japanese patients and a murine COVID-19 model. Blocking inflammatory cytokines and preventing obesity may improve survival rates.

24 May 2023

High HDL-C levels and cardiovascular risks - what you need to know!

Research paper investigates the relationship between very high levels of high-density lipoprotein cholesterol (HDL-C) and cardiovascular outcomes in the general population. The study reveals that while men with high HDL-C face an increased risk of all-cause death and cardiovascular death, this association is not observed in women without coronary artery disease.

22 May 2023

Gout unveiled as surprising culprit in neurodegenerative diseases

Research highlights the association between gout and neurodegenerative diseases, revealing that gout patients exhibit smaller brain volumes, increased brain iron markers, and a higher incidence of conditions such as dementia, Parkinson's disease, and essential tremor, particularly within the first three years after diagnosis.

22 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

What are the genetic associations between modifiable risk factors and Alzheimer's disease?

Researchers assessed associations between genetic risk factors and Alzheimer's.

19 May 2023

Is there an association between long-term plasma caffeine intake and adiposity, type 2 diabetes, and cardiovascular diseases?

Investigate the effects of long-term exposure to higher plasma caffeine concentrations on T2D, adiposity, and cardiovascular diseases.

18 May 2023

Molecular mechanism behind a DNA repair pathway revealed

A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.

16 May 2023

The discovery of a novel orthonairovirus from Dermacentor silvarum ticks near the China–North Korea border

Researchers isolated a novel virus of the Orthonairovirus genus.

16 May 2023

Novel 'CLEVER' method accelerates engineering and genetic study of SARS-CoV-2 and its variants

Researchers described rapid mutagenesis and rescue of SARS-CoV-2 variants without cloning.

16 May 2023

Rapid spread of antibiotic-resistant E. coli across Europe raises concerns

Research paper highlights the swift cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area from 2012 to June 2022. The findings emphasize the need for continued surveillance and effective measures to combat the spread of antibiotic-resistant bacteria.

15 May 2023

Novel arterivirus discovered in Amazonian rodents unveiling a potential viral spillover threat

Discovery of a novel arterivirus in Amazonian rodents sheds light on viral communities and raises concerns about potential transmission to humans.

14 May 2023

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Researchers conducted a phase I clinical trial of a personalized mRNA neoantigen vaccine.

12 May 2023

Study extends understanding of m6A modification as biological pathway underlying atrial fibrillation

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Numerous single nucleotide polymorphisms (SNPs) have been identified as genetic contributors to atrial fibrillation (AF).

11 May 2023

Neanderthal genes shape human noses

Research reports a study on the genetics of facial features in Latin Americans using automatic landmarking of 2D portraits and genome-wide association analysis. The study identified novel regions associated with facial features, including a region in 1q32.3 that shows introgression from Neanderthals and influences nasal height.

10 May 2023

New small-molecule drugs show potential clinical utility in treating world’s leading causes of blindness

In a University of California, Irvine-led study, researchers have discovered small-molecule drugs with potential clinical utility in the treatment of age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP).

9 May 2023

Anticoronavirals: the development of COVID-19 therapies and the challenges that remain

Researchers highlighted the pace of development of COVID-19 therapies during the pandemic and the challenges that hinder the widespread availability of anticoronavirals.

8 May 2023

Using PandaOmics to identify dual-purpose therapeutic targets to treat aging and glioblastoma

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform."

3 May 2023

Nucleotide News and Research

Important discovery could lead to new treatments for obesity and related diseases

Obesity strikes below the belt: Study reveals link between obesity and male infertility

Genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene shaped by exogenous exposures

COVID-19 'bites the apple': Abdominal obesity ignites cytokine storm

High HDL-C levels and cardiovascular risks - what you need to know!

Gout unveiled as surprising culprit in neurodegenerative diseases

Surviving without glucose: uridine-derived ribose as an alternative energy source

What are the genetic associations between modifiable risk factors and Alzheimer's disease?

Is there an association between long-term plasma caffeine intake and adiposity, type 2 diabetes, and cardiovascular diseases?

Molecular mechanism behind a DNA repair pathway revealed

The discovery of a novel orthonairovirus from Dermacentor silvarum ticks near the China–North Korea border

Novel 'CLEVER' method accelerates engineering and genetic study of SARS-CoV-2 and its variants

Rapid spread of antibiotic-resistant E. coli across Europe raises concerns

Novel arterivirus discovered in Amazonian rodents unveiling a potential viral spillover threat

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Study extends understanding of m6A modification as biological pathway underlying atrial fibrillation

Neanderthal genes shape human noses

New small-molecule drugs show potential clinical utility in treating world’s leading causes of blindness

Anticoronavirals: the development of COVID-19 therapies and the challenges that remain

Using PandaOmics to identify dual-purpose therapeutic targets to treat aging and glioblastoma

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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