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Researchers develop a cell line to address the challenges facing cellular modeling of disease

Bill Skarnes and team established and characterized a stable iPSC line, KOLF2.1J, to act as a high-quality baseline platform for modeling human disease.

3 Feb 2023

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Researchers evaluated the clinical and genetic characteristics of acute myeloid leukemia (AML) patients with a mutant Ikaros zinc finger protein 1 (IKZF1).

2 Feb 2023

Study solves a 50-year mystery about messenger RNAs

Messenger RNAs (mRNAs) contain chemical marks that are critical for antiviral defense in cells, according to a new study from researchers at Weill Cornell Medicine.

1 Feb 2023

Study demonstrates intrahost MPXV variation within a single lesion

Researchers reported on the clinical and molecular characteristics of MPXV infections in Finland.

31 Jan 2023

Impaired glucose tolerance and cardiovascular risk factors associated with fertility problems

The present study provided strong evidence that supported the hypothesis that hyperinsulinemia and glucose intolerance cause infertility in women.

31 Jan 2023

Comprehensive profiling of human-to-human oral and intestinal microbial transmission

Researchers identified widespread bacterial strain sharing among humans (>10 million sharing instances) with distinctive patterns of transmission including vertical transmission, transmission within households, and the population.

20 Jan 2023

Mpox has been silently circulating in non-mpox-endemic nations for 20 years, according to new study

Researchers described the evolution of the mpox virus (MPXV) before the 2022 outbreak.

19 Jan 2023

Research explores the utility of epigenetically predicted BMI

DNA methylation is an accurate predictor of current BMI and a poor predictor of future BMI.

18 Jan 2023

Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants

A new study describes that tight transmission bottlenecks restrict the evolution of SARS-CoV-2 in the transmission chain. SARS-CoV-2 is the causative pathogen of the COVID-19 pandemic.

18 Jan 2023

Combination of multiple maps uncovers new genetic risk factor for AMD

Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study publishing January 17th in the open access journal PLOS Biology by Ran Elkon and Ruth Ashery-Padan of Tel Aviv University, Israel, and colleagues.

18 Jan 2023

Exploring a novel amplicon-based mpox virus sequencing strategy

Researchers described the development of a sequencing strategy based on amplicons for mpox detection.

18 Jan 2023

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers investigated the ability of kinetin (N6-furfurylaminopurine, MB-905) to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proliferation in vitro.

17 Jan 2023

Researchers analyze the ancestry components in modern and historic VARV genomes

A recent study published in Microbial Genomics analyzed the molecular evolution of the variola virus (VARV)

13 Jan 2023

Study suggests a link between the protein-coding gene TREM2 and obesity in females

A recent Scientific Reports study has investigated the link between TREM2 expression and human obesity, based on two large public datasets, namely, the UK Biobank (UKB) and the Genotype-Tissue Expression (GTEx) project.

11 Jan 2023

The main source of editing of the mpox virus genome during the 2022 outbreak

Researchers investigated the main source of editing of the 2022 mpox virus genome.

11 Jan 2023

Genomic analysis of mpox virus genomes reveal multiple lineages with human-to-human transmissibility

Researchers from Nigeria and the United Kingdom (U.K.) analyzed mpox virus genomes and found that divergent lineages of the mpox virus exhibiting human-to-human transmission existed in the Nigerian population before the 2022 spread of the virus outside of the endemic regions.

10 Jan 2023

Researchers investigate Scandinavian history across 2,000 years

Researchers investigated the history of Scandinavia from the Roman period (between 1.0 CE and 400.0 CE) to the present, spanning over 2,000 years.

10 Jan 2023

Study shows XBB.1.5 exhibits a substantially higher hACE2-binding affinity compared to BQ.1.1 and XBB/XBB.1

Researchers investigated the reasons for the rapid advent of SARS-CoV-2 XBB.1.5, a sublineage of the Omicron recombinant mutant XBB in the USA.

6 Jan 2023

Horizontal gene transfer from mother to infant influences gut microbiome assembly, neurodevelopment, and immune maturation in infants

Researchers used a multi-omics approach to profile the gut microbiomes and metabolomes of mothers and infants to determine the vertical and horizontal transmission of bacterial species and strains as well as individual genes and understand the dynamics of the gut microbiome assembly that shape the development of the infant before and after birth.

29 Dec 2022

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine.

28 Dec 2022

Nucleotide News and Research

Researchers develop a cell line to address the challenges facing cellular modeling of disease

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Study solves a 50-year mystery about messenger RNAs

Study demonstrates intrahost MPXV variation within a single lesion

Impaired glucose tolerance and cardiovascular risk factors associated with fertility problems

Comprehensive profiling of human-to-human oral and intestinal microbial transmission

Mpox has been silently circulating in non-mpox-endemic nations for 20 years, according to new study

Research explores the utility of epigenetically predicted BMI

Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants

Combination of multiple maps uncovers new genetic risk factor for AMD

Exploring a novel amplicon-based mpox virus sequencing strategy

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers analyze the ancestry components in modern and historic VARV genomes

Study suggests a link between the protein-coding gene TREM2 and obesity in females

The main source of editing of the mpox virus genome during the 2022 outbreak

Genomic analysis of mpox virus genomes reveal multiple lineages with human-to-human transmissibility

Researchers investigate Scandinavian history across 2,000 years

Study shows XBB.1.5 exhibits a substantially higher hACE2-binding affinity compared to BQ.1.1 and XBB/XBB.1

Horizontal gene transfer from mother to infant influences gut microbiome assembly, neurodevelopment, and immune maturation in infants

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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