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New findings shed light on how gene mutation causes motor neurone disease

Researchers have discovered a mechanism that may explain how a recently discovered mutation causes two devastating neurological diseases.

6 Mar 2014

UCLA develops experimental treatment that eliminates acute type of leukemia in mice

A diverse team of scientists from UCLA's Jonsson Comprehensive Cancer Center has developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects.

28 Feb 2014

UCLA scientists developed experimental treatment that eradicates acute type of leukemia in mice

A diverse team of scientists from UCLA's Jonsson Comprehensive Cancer Center have developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread.

25 Feb 2014

Blocking mechanisms for DNA repair may help to potentiate chemotherapy, says study

Chemotherapies are cancer treatments that work by inducing lesions in the DNA of tumour cells in order to inhibit their proliferation. However, the body naturally tries to repair these lesions, and thus reduces the efficacy of chemotherapy.

24 Feb 2014

New DNA Quantification kits may help scientists to quickly assess highly compromised human DNA

Forensic scientists can now more quickly assess the quantity and quality of human DNA in highly compromised and degraded casework samples and provide the critical information needed to drive informed decisions on subsequent steps in the analysis process, thanks to two new Life Technologies quantification solutions announced today by Thermo Fisher Scientific.

21 Feb 2014

Natera initiates distribution partnership with ProPath for Panorama non-invasive prenatal screening test

Natera, a leading innovator in prenatal genetic testing, today announced the initiation of a distribution partnership with ProPath, a wholly physician-owned provider of pathology services to clinicians and medical facilities in the United States, for its Panorama non-invasive prenatal screening test (NIPT).

From Natera 12 Feb 2014

Gilead submits NDA to FDA for fixed-dose combination of ledipasvir and sofosbuvir for hepatitis C infection

Gilead Sciences, Inc. (Nasdaq: GILD) today announced that the company has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for a once-daily fixed-dose combination of the NS5A inhibitor ledipasvir (LDV) 90 mg and the nucleotide analog polymerase inhibitor sofosbuvir (SOF) 400 mg for the treatment of chronic hepatitis C genotype 1 infection in adults.

11 Feb 2014

New study co-led by scientists sheds light on role of genes, blood lipid levels in cardiovascular health

New genetic evidence strengthens the case that one well-known type of cholesterol is a likely suspect in causing heart disease, but also casts further doubt on the causal role played by another type.

10 Feb 2014

Researchers shed light on role of genes and blood lipid levels in cardiovascular health

New genetic evidence strengthens the case that one well-known type of cholesterol is a likely suspect in causing heart disease, but also casts further doubt on the causal role played by another type. The findings may guide the search for improved treatments for heart disease.

9 Feb 2014

NeuroRehabilitation showcases different approaches to restoring mental functioning

There is a growing need for Cognitive Rehabilitation Therapy (CRT) due to the huge influx of soldiers returning from war zones with brain injuries, athletes with sports-related head injuries, and the growing population with age-related cognitive decline.

4 Feb 2014

Susceptible loci identified for bipolar I disorder in Taiwanese

Researchers have identified three genetic loci that may be linked to bipolar I disorder risk in Taiwanese individuals.

29 Jan 2014

Gilead Sciences gets marketing authorization from European Commission for Sovaldi 400 mg tablets

Gilead Sciences, Inc. today announced that the European Commission has granted marketing authorization for Sovaldi (sofosbuvir) 400 mg tablets, a once-daily oral nucleotide analogue polymerase inhibitor for the treatment of chronic hepatitis C infection in adults, in combination with other antiviral agents (ribavirin and pegylated interferon alpha (peg-IFN)).

18 Jan 2014

RNA sequencing unlocks bipolar secrets

An RNA sequencing study of patients with bipolar disorder has shown altered expression of genes and transcripts, including those involved in neuroplasticity and circadian rhythms.

16 Jan 2014

Finland researchers identify mechanism that enhances prostate cancer proliferation, metastasis

A research group at Biocenter Oulu in Finland has identified a mechanism related to a transcription factor that binds much more strongly onto a particular SNP variant, thereby initiating a genetic programme which enhances prostate cancer proliferation and metastasis.

13 Jan 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery

The results of the largest international study to date into the genetic basis of rheumatoid arthritis shed light on the biology of the disease and provide evidence that large-scale genetic studies can assist in the identification of new drugs for complex disorders such as rheumatoid arthritis.

26 Dec 2013

Schizophrenia brain marker matches genetic risk

Polygenic risk for schizophrenia correlates with neural inefficiency in the left dorsolateral prefrontal cortex, say researchers.

24 Dec 2013

Finding suggests new route for packaging RNA molecules of interest into nanovesicles

The role of microRNAs is fundamental for the correct moment-to-moment adjustment in the expression of target genes. "Before this study, we already knew that these small molecules could be packaged into small vesicles and exported to the extracellular space, to be later captured by other cells and in this way play an important role in intercellular communication," explains CNIC researcher Carolina Villarroya, the first author on the study.

23 Dec 2013

Researchers map cell's complex genetic interactions to fix UV damaged DNA

Researchers at the University of California, San Diego School of Medicine, with colleagues in The Netherlands and United Kingdom, have produced the first map detailing the network of genetic interactions underlying the cellular response to ultraviolet (UV) radiation.

19 Dec 2013

Shared genetic risk for bipolar disorder and BMI

Researchers have found a positive association in the heritability of bipolar disorder and body mass index, supporting the theory that there is some interaction in the genetic mechanisms underlying these two traits.

19 Dec 2013

Study reveals why people are predisposed to cardiovascular disease and death

A genetic trait known to make some people especially sensitive to stress also appears to be responsible for a 38 percent increased risk of heart attack or death in patients with heart disease, scientists at Duke Medicine report.

19 Dec 2013

Nucleotide News and Research

New findings shed light on how gene mutation causes motor neurone disease

UCLA develops experimental treatment that eliminates acute type of leukemia in mice

UCLA scientists developed experimental treatment that eradicates acute type of leukemia in mice

Blocking mechanisms for DNA repair may help to potentiate chemotherapy, says study

New DNA Quantification kits may help scientists to quickly assess highly compromised human DNA

Natera initiates distribution partnership with ProPath for Panorama non-invasive prenatal screening test

Gilead submits NDA to FDA for fixed-dose combination of ledipasvir and sofosbuvir for hepatitis C infection

New study co-led by scientists sheds light on role of genes, blood lipid levels in cardiovascular health

Researchers shed light on role of genes and blood lipid levels in cardiovascular health

NeuroRehabilitation showcases different approaches to restoring mental functioning

Susceptible loci identified for bipolar I disorder in Taiwanese

Gilead Sciences gets marketing authorization from European Commission for Sovaldi 400 mg tablets

RNA sequencing unlocks bipolar secrets

Finland researchers identify mechanism that enhances prostate cancer proliferation, metastasis

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Schizophrenia brain marker matches genetic risk

Finding suggests new route for packaging RNA molecules of interest into nanovesicles

Researchers map cell's complex genetic interactions to fix UV damaged DNA

Shared genetic risk for bipolar disorder and BMI

Study reveals why people are predisposed to cardiovascular disease and death

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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