Oligonucleotides News and Research

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Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer bases. Automated synthesizers allow the synthesis of oligonucleotides up to 160 to 200 bases.

Hybridon collaborates to develop immune modulatory (IMO) compounds for asthma and allergy

Hybridon today announced it had entered into research collaboration and license agreements with Novartis for the discovery, optimization, development and commercialization of Toll-like receptor 9 (TLR9) drug candidates targeting asthma and allergy based on Hybridon's proprietary immune modulatory oligonucleotide (IMO) technology platform.

1 Jun 2005

Technology for analyzing gene expression must be standardized

Technology for analyzing gene expression must be standardized among laboratories and across platforms around the world to support this age of human genome exploration, an Oregon Health & Science University researcher says.

29 May 2005

Novel nanotechnology detects human DNA mutations

Researchers at Nanosphere, Inc. have reported unprecedented benefits in the company's technology for the medical analysis of human DNA.

26 Jan 2005

FDA approves Topigen's investigational New Drug Application for new inhalation drug to treat asthma

Phase 1 clinical trial can be initiated for ASM8, a new inhalation drug that is designed to treat asthma through a unique approach by attacking multiple mediators of the inflammatory mechanism rather than the single mediator approach of current therapies.

8 Dec 2004

Lorus Therapeutics allowed Canadian patent to protect anticancer drugs

Lorus Therapeutics today announced that its wholly owned subsidiary, GeneSense Technologies Inc., has been allowed a patent by the Canadian Patent Office entitled "Antitumor Antisense Sequences Directed Against R1 and R2 Components of Ribonucleotide Reductase."

10 Nov 2004

STAT3 protein could lead to new ways to prevent skin cancer

Scientists at The University of Texas M. D. Anderson Cancer Center have identified a protein that serves as a master regulator of skin cancer - a finding that could lead to new ways to prevent skin cancer before it starts.

4 Nov 2004

Researchers discover that DNA fragments destroy melanoma cells

Researchers at Boston University School of Medicine have discovered that small DNA fragments or oligonucleotides that resemble the telomere (chromosome end), also called T-oligos, can cause human melanoma cells to undergo extensive apoptosis (cell death), while surviving melanoma cells become more differentiated and therefore less aggressive.

1 Sep 2004

New service-oriented laboratory focused on bioanalysis and pharmacokinetics

Oregon Health & Science University researchers will more quickly move benchtop discoveries toward drug discoveries with the help of a new, service-oriented laboratory focused on bioanalysis and pharmacokinetics.

11 Aug 2004

Total global market for oligonucleotides is likely to grow from USD 340.0 million in 2003 to USD 776.0 million in 2010

Poised on the brink of phenomenal growth, the oligonucleotides market offers a plethora of opportunities to the enterprising investor. Recent analysis by Frost & Sullivan estimates that the total global market for oligonucleotides is likely to grow from USD 340.0 million in 2003 to USD 776.0 million in 2010.

9 Aug 2004

Surprising differences in the DNA of normal cells from different people

A new study by Michael Wigler’s group at Cold Spring Harbor Laboratory has, in collaboration with researchers from Karolinska Institutet, revealed surprising differences in the DNA of normal cells from different people.

23 Jul 2004

Market research 'World RNAi Markets: Current and Future Outlook'

Gene silencing by RNAi has now been identified as a crucial technology for target validation and therapeutics. By targeting and interfering with messenger RNA (mRNA), RNAi technology blocks the expression of the proteins implicated in disease progression.

19 Jul 2004