Opioids News and Research

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An opioid is a chemical that works by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract. The receptors in these two organ systems mediate both the beneficial effects and the side effects of opioids.

Link between eating and pain relief - brain stem blocks pain to protect key behaviors

Certain behaviors, such as eating, drinking and urinating, are so crucial to survival that the brains of all vertebrates contain clusters of nerve cells that can suppress pain long enough to allow the animal to eat, drink - or pee - in peace.

15 Nov 2005

Fentanyl transdermal patch is an effective way to control pain in children

A new study says using a transdermal patch to deliver the opioid fentanyl is an effective way to control pain in children

14 Nov 2005

Studies outline dangers of mixing stress, deprivation and tempting foods

Two studies in the October issue of Behavioral Neuroscience show that when animals are stressed, deprived and exposed to tempting food, they overeat, with different degrees of interaction.

7 Nov 2005

Evaluation of the efficacy of buprenorphine hydrochloride and clonidine hydrochloride, in detoxification of opioid-dependent teenagers

In a comparison of two drugs prescribed to treat teenagers dependent on heroin and other opioids, the drug buprenorphine was more effective, especially in treatment retention, according to a study in the October issue of Archives of General Psychiatry.

4 Oct 2005

Possibility of tailored treatments for addiction based on how a person's genes behave

Scientists have learned how a genetic variation long suspected in making some people susceptible to alcoholism and narcotic drug addiction actually does so.

27 Sep 2005

Brain can be tricked into thinking the pain has gone

A new U.S. study has found that it is possible that by just thinking that a medicine will relieve pain is enough to prompt the brain to release its own natural painkillers, and soothe painful sensations.

24 Aug 2005

First direct evidence that endorphins play a role in the phenomenon known as the placebo effect

Just thinking that a medicine will relieve pain is enough to prompt the brain to release its own natural painkillers, and soothe painful sensations, a new University of Michigan study finds.

23 Aug 2005

Mixing slow-release painkillers with alcohol - potentially deadly

Health Canada has issued a warning that mixing some slow-release painkillers with alcohol could be potentially deadly.

4 Aug 2005

Prescription drug abuse in the USA exceeds 15 million

A recently released report by the National Center on Addiction and Substance Abuse at Columbia University suggests between 1992 and 2003, more Americans were abusing controlled prescription drugs than cocaine, hallucinogens, inhalants and heroin put together.

11 Jul 2005

Combining morphine with small doses of methadone could increase the effectiveness of morphine for the treatment of chronic pain

Although morphine is well known as a highly effective analgesic, its clinical utility is severely limited by the development of drug tolerance, the requirement for increasing doses to maintain analgesic effect, and the development of physical dependence.

6 Jun 2005

Link between the protective effect of ischemic preconditioning in skeletal muscles and the substance that triggers hibernation

A phenomenon known as ischemic preconditioning (IP), in which blood flow to muscle is reduced and then restored, has previously been shown to increase muscle function, especially in the heart.

6 Jun 2005

Narcotic medications can safely and effectively ease severe, chronic pain in older people

Narcotic medications can safely and effectively ease severe, chronic pain in older people with little risk that these patients will seek ever-increasing doses, UCSF medical scientists have found. Younger patients, however, are likely to want to rapidly increase their medication dose, the researchers found, posing serious potential health consequences.

23 May 2005

Narcotic medications can safely and effectively ease severe, chronic pain in older people

Narcotic medications can safely and effectively ease severe, chronic pain in older people with little risk that these patients will seek ever-increasing doses, University of California, San Francisco (UCSF) medical scientists have found. Younger patients, however, are likely to want to rapidly increase their medication dose, the researchers found, posing serious potential health consequences.

20 May 2005

Use of major opioid drugs combined with a history of previous relapse increased the likelihood of another relapse

The risk of relapse is significantly increased for health-care professionals treated for substance use disorders if they have coexisting psychiatric illness or a family history of substance abuse.

23 Mar 2005

International expert group discusses alternatives to COX-2 inhibitors

International group of pain specialists meets to develop recommendations for the treatment of chronic moderate-to-severe pain in the wake of the global withdrawal of rofecoxib (Vioxx) and concerns regarding use of other COX-2 inhibitors.

7 Mar 2005

Naltrexone helps alcoholics moderate their drinking

A little-known drug called naltrexone provides a “meaningful benefit” in helping alcoholics moderate their drinking, according to the latest review of evidence from 29 studies on four continents.

20 Feb 2005

Ingestion of afterbirth appears to promote maternal behavior in mammals

A behavioral neuroscientist at the University at Buffalo holds that the ingestion of afterbirth by a mother, a feature of pregnancy in nearly all non-human mammals, not only relieves postpartum pain, but optimizes the onset of maternal behavior by mediating the activity of specific opioid activity circuits in the brain.

13 Feb 2005

Are NSAIDS enough for cancer pain?

Non-steroidal anti-inflammatory drugs (NSAIDs) are effective in managing cancer pain with few side effects, according to a new review of a number of studies.

24 Jan 2005

FDA approves Combunox tablets for the short-term treatment of acute, moderate to severe pain

Forest Laboratories have announced that Combunox (Oxycodone HCl and Ibuprofen) Tablets (CII), the first and only fixed-dose combination of the opioid oxycodone HCl (5 mg) and the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen (400 mg), was approved by the U.S. Food and Drug Administration (FDA) for the short-term management of acute, moderate to severe pain.

29 Nov 2004

Long-term use of opioid prescriptions by veterans

Veteran patients who receive long-term opioid prescriptions generally are treated with modest and stable medication dosages, according to an article in the November 22 issue of The Archives of Internal Medicine, one of the JAMA/Archives journals.

23 Nov 2004

Opioids News and Research

Further Reading

Link between eating and pain relief - brain stem blocks pain to protect key behaviors

Fentanyl transdermal patch is an effective way to control pain in children

Studies outline dangers of mixing stress, deprivation and tempting foods

Evaluation of the efficacy of buprenorphine hydrochloride and clonidine hydrochloride, in detoxification of opioid-dependent teenagers

Possibility of tailored treatments for addiction based on how a person's genes behave

Brain can be tricked into thinking the pain has gone

First direct evidence that endorphins play a role in the phenomenon known as the placebo effect

Mixing slow-release painkillers with alcohol - potentially deadly

Prescription drug abuse in the USA exceeds 15 million

Combining morphine with small doses of methadone could increase the effectiveness of morphine for the treatment of chronic pain

Link between the protective effect of ischemic preconditioning in skeletal muscles and the substance that triggers hibernation

Narcotic medications can safely and effectively ease severe, chronic pain in older people

Narcotic medications can safely and effectively ease severe, chronic pain in older people

Use of major opioid drugs combined with a history of previous relapse increased the likelihood of another relapse

International expert group discusses alternatives to COX-2 inhibitors

Naltrexone helps alcoholics moderate their drinking

Ingestion of afterbirth appears to promote maternal behavior in mammals

Are NSAIDS enough for cancer pain?

FDA approves Combunox tablets for the short-term treatment of acute, moderate to severe pain

Long-term use of opioid prescriptions by veterans

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