Opioids News and Research

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An opioid is a chemical that works by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract. The receptors in these two organ systems mediate both the beneficial effects and the side effects of opioids.

Use of major opioid drugs combined with a history of previous relapse increased the likelihood of another relapse

The risk of relapse is significantly increased for health-care professionals treated for substance use disorders if they have coexisting psychiatric illness or a family history of substance abuse.

23 Mar 2005

International expert group discusses alternatives to COX-2 inhibitors

International group of pain specialists meets to develop recommendations for the treatment of chronic moderate-to-severe pain in the wake of the global withdrawal of rofecoxib (Vioxx) and concerns regarding use of other COX-2 inhibitors.

7 Mar 2005

Naltrexone helps alcoholics moderate their drinking

A little-known drug called naltrexone provides a “meaningful benefit” in helping alcoholics moderate their drinking, according to the latest review of evidence from 29 studies on four continents.

20 Feb 2005

Ingestion of afterbirth appears to promote maternal behavior in mammals

A behavioral neuroscientist at the University at Buffalo holds that the ingestion of afterbirth by a mother, a feature of pregnancy in nearly all non-human mammals, not only relieves postpartum pain, but optimizes the onset of maternal behavior by mediating the activity of specific opioid activity circuits in the brain.

13 Feb 2005

Are NSAIDS enough for cancer pain?

Non-steroidal anti-inflammatory drugs (NSAIDs) are effective in managing cancer pain with few side effects, according to a new review of a number of studies.

24 Jan 2005

FDA approves Combunox tablets for the short-term treatment of acute, moderate to severe pain

Forest Laboratories have announced that Combunox (Oxycodone HCl and Ibuprofen) Tablets (CII), the first and only fixed-dose combination of the opioid oxycodone HCl (5 mg) and the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen (400 mg), was approved by the U.S. Food and Drug Administration (FDA) for the short-term management of acute, moderate to severe pain.

29 Nov 2004

Long-term use of opioid prescriptions by veterans

Veteran patients who receive long-term opioid prescriptions generally are treated with modest and stable medication dosages, according to an article in the November 22 issue of The Archives of Internal Medicine, one of the JAMA/Archives journals.

23 Nov 2004

Biotoxin from puffer fish may provide treatment for opioid withdrawal

On November 10, 2004 investigators involved in a Phase IIa clinical trial of the novel biotoxin Tetrodotoxin (TTX) for the treatment of opioid withdrawal enrolled their first participants.

18 Nov 2004

Reproductive hormones have effects on all of these stages of brain growth and development

Scientists are now uncovering increasing evidence that the brain not only responds to hormones produced by the reproductive system, but that these hormones-the so-called "female hormones," estrogen and progestin, and the "male" androgens, such as testosterone-play an important role in the development of differences between male and female brains.

2 Nov 2004

Smoking shown to quell painful sensations and heighten positive emotions

Smokers often say that lighting up a cigarette can calm their nerves, satisfy their craving and help them relax.

28 Oct 2004

Guideline evaluates treatments for postherpetic neuralgia

A new guideline from the American Academy of Neurology evaluates treatments for postherpetic neuralgia. The guideline is published in the September 28 issue of Neurology, the scientific journal of the American Academy of Neurology.

28 Sep 2004

Palladone approved for pain relief

The Food and Drug Administration (FDA) has approved Palladone (hydromorphone hydrochloride) capsules for the management of persistent moderate to severe pain in patients requiring continuous around-the-clock opioid pain relief for an extended period of time.

26 Sep 2004