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Rethinking the germ theory: A balanced take on microbes and disease outcomes

Review explores the complexities of infectious disease outcomes through a balanced perspective, emphasizing the interplay between pathogenic microbes and host conditions, challenging the traditional germ-disease theory by proposing a more integrated view that considers both pathogen virulence and host immunity's impact on disease manifestation.

10 Apr 2024

How strep bacteria outsmart your immune system and why it matters for treatment

Researchers discover that Group A streptococcal infections alter immunoglobulin G (IgG) homeostasis to evade the immune system, affecting the transition from local to systemic infections. The study also raises concerns about the effectiveness of antibody-based therapies, as the bacteria's virulence factors can degrade therapeutic antibodies.

25 Oct 2023

Cocktail of IgG3 antibodies could have a potent clinical effect against SARS-CoV-2

Is it possible to improve the antibodies that the body produces to fight SARS-CoV2? In a study led by researchers from Lund University in Sweden, this was investigated by redesigning antibodies and combining them against the virus.

18 Apr 2023

Researcher contextualizes a study on IgG4 anti-Spike levels after repeated SARS-CoV-2 mRNA vaccination

A researchers emphasized the need to reconsider mRNA COVID-19 vaccination strategies in the future,

9 Feb 2023

A review of innate immunity relevant to SARS-CoV-2 and COVID-19

In a recent study published in The New England Journal of Medicine, researchers reviewed selected acute-phase proteins concerning their production, structure, and function.

7 Feb 2023

Researchers propose a deep antibody-antigen interaction algorithm to accelerate the identification of potential therapeutic antibodies

Researchers used a deep antibody-antigen interaction (DeepAAI) algorithm to understand the antibody representations of unseen antibodies to accelerate the discovery of novel antibodies with potential therapeutic applications.

9 Nov 2022

Scientists explore kinetics of naturally induced anti-SARS-CoV-2 antibodies in the Kenyan population

In a new study, researchers investigated the breadth and longevity of immunity induced by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure among the Kenyan population.

10 Oct 2022

The possible immune-mediated mechanisms causing CNS alterations during and post-acute SARS-CoV-2 infection

In a recent review published in Immunity, researchers explored potential mechanisms of neuro-immune pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

22 Jun 2022

Isolation of potent neutralizing monoclonal antibodies using nanoparticles displaying SARS-CoV-2 S glycoprotein

A new study aimed to identify several potent neutralizing RBD-directed and NTD-directed mAbs that used a nanoparticle displaying the S glycoprotein to capture SARS-CoV-2-specific B cells.

2 Nov 2021

New research on phagocytosis and SARS-CoV-2's spike protein

A new study showed that convalescent patient plasma and monoclonal anti-spike antibodies were able to induce phagocytosis at high antibody concentrations.

20 Oct 2021

Why does convalescent plasma therapy for severe COVID-19 show mixed success?

A surprising new preprint, released on the medRxiv* server, suggests that the beneficial effects of convalescent plasma (CP) in this disease stem not only from the presence of neutralizing antibodies, but also the immunomodulatory effects of this plasma that shapes the host immune response.

15 Mar 2021

Using neutralising antibodies in the fight against COVID-19

While many scientists and pharmaceutical companies are racing to develop a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine, there is also an urgent need for a coronavirus disease (COVID-19) treatment. The potent virus has now spread to 210 countries and territories, affecting more than 3.04 million people. Now, a team of German scientists is working on using antibodies to prevent and treat COVID-19.

27 Apr 2020

Immune response more complicated than thought

Researchers have found that the orientation and concentration of antibodies could determine the control of bacterial infection.

28 Dec 2012

Helicobacter pylori can multiply in autophagic vesicles

Helicobacter pylori , a Gram-negative, flagellated, microaerophilic bacterium, can selectively colonize in the human stomach.

29 Jan 2009