Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

New human colon-on-a-chip enables in vitro study of mucus physiology

We have a mutualistic but complicated relationship with the collection of microbes in our gut known as the intestinal microbiome.

3 Dec 2019

LACV-infected cerebral organoids reveal how to protect neurons from virus-induced death

Scientists have determined that La Crosse virus, which can cause inflammation of the brain, or encephalitis, in children, affects brain cells differently depending on their developmental stage.

26 Nov 2019

Scientists grow complex organoids in the lab

Scientists at the University of Würzburg have successfully produced human tissues from stem cells. They have a complexity similar to that of normal tissue and are far superior to previous structures.

19 Nov 2019

The Achilles heel of APC-mutated colon tumors identified

In almost all cases of colon cancer, a specific gene is mutated – this offers opportunities to develop broadly effective therapeutic approaches. Research teams in Würzburg have taken this a step further.

5 Nov 2019

MSU research team wins NIH grant to explore new way to study the gut's immune system

One day, instead of requiring a painful needle injection, vaccinating against a host of formerly fatal diseases could be as simple as swallowing a pill. But getting to that point means first gaining a better understanding of how the immune system works in the complex human gut, according to Montana State University researcher Diane Bimczok.

30 Oct 2019

Study seeks participants with VCFS-related psychosis to help create biobank of cerebral organoids

A landmark study is calling for at least 50 people in the U.S. with Velo-Cardio-Facial Syndrome (VCFS)-related psychosis to provide blood samples to create the world’s largest VCFS biobank to date of tiny spheres of neural tissue called "cerebral organoids."

24 Oct 2019

New NPO formed to accelerate development of therapies for Shankopathies

Parents of children affected by Phelan-McDermid syndrome (PMS) announce the formation of CureSHANK, a nonprofit organization on a mission to accelerate drug development in PMS and other diseases related to the SHANK genes for which there are currently no FDA approved treatments.

23 Oct 2019

Binghamton biomedical professor receives $1.2 million in grants toward diabetes cure

A biomedical engineering professor at Binghamton University, State University of New York is trying to find a cure for diabetes from several different angles, and three federal grants totaling nearly $1.2 million will aid her and her research team in that quest.

21 Oct 2019

Highly sensitive method can 'track' fat metabolism

Without fat, nothing works in the body: These substances serve as energy suppliers and important building blocks - including for the envelopes of living cells.

14 Oct 2019

Scientists demonstrate potential method for treating advanced liver cancers

Liver cancer is the second leading cause of cancer-related deaths worldwide. The most common primary liver cancer in adults is known as hepatocellular carcinoma (HCC), and accounts for approximately 780,000 deaths every year.

9 Oct 2019

Scientists use organoid technology to achieve stable long-term cultures of mouse urothelial cells

Investigation of biological mechanisms in urothelial tissue -one of the three types of tissue that make up the urinary system- has always been very limited due to the lack of technologies that allow working with stable and long-term populations of the cells that compose it.

4 Oct 2019

Rapid progress in brain organoid research prompts ethical debate

A new paper has tried to address the ethical debate surrounding human organoids by evaluating the potential risks of creating “humanized” animals

4 Oct 2019

Penn researchers propose ethical framework that defines brain organoid transplantation

As research involving the transplantation of human "mini-brains"--known as brain organoids--into animals to study disease continues to expand, so do the ethical debates around the practice.

4 Oct 2019

New anticancer molecule shows therapeutic activity in preclinical models of various cancer types

A novel anticancer molecule created by researchers at The Wistar Institute showed therapeutic activity in preclinical models of various cancer types.

3 Oct 2019

New project to examine roles of microgravity and cosmic radiation in tumor growth, development

Can weightlessness stop cancer from growing? One of the nine research projects that has been given the go-ahead for the new China Space Station scheduled for 2022 is designed to answer this exact question.

3 Oct 2019

Functional three-organoid stem cell system could lead to unprecedented advances for precision medicine

Using iPS cells, a Japanese research group has successfully grown a connected set of organs at the same time, including a liver and a pancreas connected by a bile duct.

27 Sep 2019

Toxin may play key role in promoting transmission of deadly E. coli strains in cattle

Shiga toxin subtype 2a (Stx2a) may play a key role in promoting the colonization and transmission of life-threatening Escherichia coli strains in cattle, according to a study published October 3 in the open-access journal PLOS Pathogens by Tom McNeilly of the Moredun Research Institute, David Gally of the University of Edinburgh, and colleagues.

From PLOS ONE 27 Sep 2019

Physiologists, researchers to discuss factors underlying cardiovascular disease at APS conference

International physiologists and researchers studying the kidney, high blood pressure and related medical conditions will convene next week at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.

25 Sep 2019

Space-based investigation helps address challenges involved in learning more about the human brain

Researchers studying neurological diseases face several daunting challenges. For one thing, these conditions may take years or even decades to develop.

25 Sep 2019

Pros and cons of gene editing technology

CRISPR technology has greatly facilitated gene editing. Associate Professor Thorsten Müller from Ruhr-Universität Bochum and Dr. Hassan Bukhari from Harvard Medical School discuss its pros and cons in a review article in the journal "Trends in Cell Biology" from 12 September 2019.

17 Sep 2019

Organoids News and Research

Further Reading

New human colon-on-a-chip enables in vitro study of mucus physiology

LACV-infected cerebral organoids reveal how to protect neurons from virus-induced death

Scientists grow complex organoids in the lab

The Achilles heel of APC-mutated colon tumors identified

MSU research team wins NIH grant to explore new way to study the gut's immune system

Study seeks participants with VCFS-related psychosis to help create biobank of cerebral organoids

New NPO formed to accelerate development of therapies for Shankopathies

Binghamton biomedical professor receives $1.2 million in grants toward diabetes cure

Highly sensitive method can 'track' fat metabolism

Scientists demonstrate potential method for treating advanced liver cancers

Scientists use organoid technology to achieve stable long-term cultures of mouse urothelial cells

Rapid progress in brain organoid research prompts ethical debate

Penn researchers propose ethical framework that defines brain organoid transplantation

New anticancer molecule shows therapeutic activity in preclinical models of various cancer types

New project to examine roles of microgravity and cosmic radiation in tumor growth, development

Functional three-organoid stem cell system could lead to unprecedented advances for precision medicine

Toxin may play key role in promoting transmission of deadly E. coli strains in cattle

Physiologists, researchers to discuss factors underlying cardiovascular disease at APS conference

Space-based investigation helps address challenges involved in learning more about the human brain

Pros and cons of gene editing technology

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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