Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Scientists create 'mini-brain' for studying sporadic Creutzfeldt-Jakob disease

National Institutes of Health scientists have used human skin cells to create what they believe is the first cerebral organoid system, or "mini-brain," for studying sporadic Creutzfeldt-Jakob disease.

16 Jun 2019

Trump administration cracks down on fetal tissue research

The Trump administration is cutting funding for fetal tissue research despite opposition from scientists and clinicians.

10 Jun 2019

Scientists highlight advances and uses of organoids in gastroenterology and hepatology

One of the most exciting advancements in stem cell research has been the development of organoid systems, which are organ-like three-dimensional structures that mimic their corresponding organ in vivo.

4 Jun 2019

Certain cancer drugs induce stem cell plasticity in colorectal cancer

Scientists from the German Cancer Research Center and the Mannheim University Medical Center have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signaling pathway in colorectal cancer cells.

16 May 2019

Big data helps determine better research models to fight the spread of breast cancer

Scientists are using a lot of genomic data to identify medical issues sooner in patients, but they're also using it to assist their scientific counterparts in researching diseases better.

15 May 2019

MDI Biological Laboratory receives $30,000 to support course in organoid technology

The MDI Biological Laboratory has announced that it has received more than $30,000 in cash and in-kind awards in support of its second annual "Applications of Organoid Technology" course, to be held May 26 through June 1 at the institution's Bar Harbor campus.

14 May 2019

Researchers create ‘mini-guts’ to explore how gut epithelium respond to gluten in celiac patients

In pursuit of a novel tool for the research and treatment of celiac disease, scientists at the Mucosal Immunology and Biology Research Center at Massachusetts General Hospital have validated the use of intestinal organoids.

8 May 2019

Potential stem cell therapies moving from lab bench to clinical application

Stem cell research is leading to potential new therapies to treat disease, with several applications in clinical trials or expected to enter trials in the coming months.

3 May 2019

Researchers gain new insight into Alzheimer's using organoids that resemble mini brains

In the majority of cases, dementia can be traced back to Alzheimer's disease. Its causes are not really understood yet. What is known is that plaques form from misfolded proteins and that there is an increase in neuronal cell death levels in the brain. However, the plaques don't necessarily go hand in hand with any symptoms.

30 Apr 2019

Biologists unravel new role for nervous system in regeneration

Biologists at Tufts University have developed a computational model of planarian (flatworm) regeneration that explains how fragments of planaria determine which end should form a tail and which should form a head.

25 Apr 2019

Two new epigenetic regulators maintain self-renewal of embryonic stem cells

Embryonic stem cells have the ability to self-renew, and, being pluripotent have the potential to create almost any cell type in the body.

19 Apr 2019

Johns Hopkins scientists design new cell model of aging-associated colon cancer risk

Johns Hopkins Kimmel Cancer Center researchers say a new study of clusters of mouse cells known as "organoids" has significantly strengthened evidence that epigenetic changes, common to aging, play a essential role in colon cancer initiation.

12 Apr 2019

Study reveals new way to increase population of intestinal stem cells

Cells that line the intestinal tract are replaced every few days, a high rate of turnover that relies on a healthy population of intestinal stem cells. MIT and University of Tokyo biologists have now found that aging takes a toll on intestinal stem cells and may contribute to increased susceptibility to disorders of the gastrointestinal tract.

29 Mar 2019

European Research Council awards grant for research on insulin-producing cells

The ERC Advanced Grant is one of the most prestigious funding programmes for research in Europe. Per-Olof Berggren, professor of experimental endocrinology at Karolinska Institutet, is now awarded this grant for the second time.

28 Mar 2019

Health risks linked with cocktail of man-made chemicals are overlooked

The cocktail of man-made chemicals that we are exposed to daily is a health risk which current regulations and risk assessment overlook. This is the conclusion of the EU Horizon 2020 EDC-MixRisk project that is now being presented.

27 Mar 2019

Repurposing drugs to outsmart cancers

In an article published today by SAGE Publishing, investigators from The Nagourney Cancer Institute and The Albert Einstein Israelite Hospital in São Paulo, Brazil, announced a new approach to identifying effective treatments for patients with advanced metastatic cancers. A drug commonly used to treat kidney and liver cancer was discovered effective for breast cancer, which may open new drug therapies to patients regardless of tumor type.

22 Mar 2019

Scientists grow most sophisticated brain organoid to date

Researchers at Cambridge Biomedical Campus have grown the most sophisticated brain organoid to date, providing new opportunities for scientists to understand human brain development and neurological disorders.

20 Mar 2019

Human microbiome metabolites enhance colon injury by enterohemorrhagic E. coli, study shows

It remains mysterious why humans get infected by some bacterial or viral pathogens relatively easily while animals that have very similar tissues and immune functions do not.

20 Mar 2019

“Fail Fast, But More Confidently”: Developing Organoids for Drug Development and Discovery

Richard Eglen discusses the use of organoids in drug discovery, including the screening of candidate compounds for efficacy, toxicity, and pharmacokinetics.

From Corning Life Sciences 13 Mar 2019

Creating increasingly complex brain organoids

Scientists improved the initial steps of a standard protocol and produced organoids displaying regionalized brain structures, including retinal pigmented cells. The announcement was published today in BMC Developmental Biology by the D'Or Institute for Research and Education's team.

8 Mar 2019