Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Researchers discover new gene targets for precision oncology in esophageal cancer

Researchers have identified a new way to screen genes that cause several different types of cancers to grow, identifying particularly promising targets for precision oncology in oral and esophageal squamous cancers.

28 Nov 2023

New heart organoid model could revolutionize drug development and toxicology studies

Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far.

28 Nov 2023

New cortex organoids more accurately represent the human brain

Essential features of the cortex, an important part of the human brain and its development, are more accurately captured in organoids generated by researchers of the Princess Máxima Center for pediatric oncology and the Hubrecht Institute.

28 Nov 2023

Genetic mutation in OXR1 gene linked to brain development issues

Study investigates the effects of a loss-of-function mutation in the OXR1 gene on neurodevelopment and cellular functions in the human brain. The research shows that OXR1 deficiency impairs neural differentiation, increases sensitivity to oxidative stress, and alters histone methylation, impacting brain development and potentially contributing to neurological disorders.

27 Nov 2023

Unveiling the role of Daam1 gene in intestinal stem cell fate decisions

Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation?

24 Nov 2023

Researchers discover way to reverse brain aging caused by COVID-19

University of Queensland researchers have found a way to reverse a cellular process triggered by COVID-19 that contributes to premature aging of the brain.

22 Nov 2023

New organoid model could lead to personalized treatments for colon-related diseases

A team at the Medical University of South Carolina and Cincinnati Children's has developed a sophisticated model for studying the diseased colon that could lead to the development of personalized treatments for colon-related diseases, such as cancer and inflammatory bowel disease (IBD).

20 Nov 2023

Uncontrolled growth as a cancer cell's weakness

Growth is a fundamental biological process and a prerequisite for living organisms to develop and reproduce. The processes of cell growth (i.e. the production of new biomass) and of cell division must be coordinated with each other.

17 Nov 2023

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Study reveals that senolytics can reduce aging in human brain organoids and mitigate COVID-19 neuropathology, suggesting their potential as a therapeutic strategy against brain aging and coronavirus-related neurological complications.

15 Nov 2023

Stand Up To Cancer unveils new gastroesophageal cancer research teams and awards

Stand Up To Cancer (SU2C) today announced three Research Teams focused on bringing new therapies to clinical trials for the treatment of gastroesophageal cancer (GEC).

15 Nov 2023

Microglia found to play crucial role in early human brain development

An international team of scientists has uncovered the vital role of microglia, the immune cells in the brain that acts as its dedicated defense team, in early human brain development.

14 Nov 2023

Crown Bioscience launches large-scale organoid panel screening platform for accelerated preclinical oncology drug discovery

Crown Bioscience, a global contract research organization (CRO) and JSR Life Sciences company, today announced the launch of its ground-breaking service offering, OrganoidXploreTM.

13 Nov 2023

Study reveals early role of SYNGAP1 gene in brain development

The gene SYNGAP1, the variants of which are top risk factors for Autism Spectrum Disorder (ASD), has previously unappreciated effects on the developing brain, according to a new study published in Nature Neuroscience.

9 Nov 2023

Gut bacteria promote social behavior and wound healing through oxytocin signaling

The gut microbiome, a community of trillions of microbes living in the human intestines, has an increasing reputation for affecting not only gut health but also the health of organs distant from the gut.

2 Nov 2023

Study sheds light on origins of breast cancer in people with BRCA2 mutations

A pioneering study led by Professor Ashok Venkitaraman from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore and Dr Mona Shehata from the University of Cambridge (UK) has uncovered vital insights into the distinct effects of BRCA2 mutations on breast tissue cells, shedding light on early breast cancer development in people with BRCA2 mutations.

1 Nov 2023

Organoids News and Research

Further Reading

Researchers discover new gene targets for precision oncology in esophageal cancer

New heart organoid model could revolutionize drug development and toxicology studies

New cortex organoids more accurately represent the human brain

Genetic mutation in OXR1 gene linked to brain development issues

Unveiling the role of Daam1 gene in intestinal stem cell fate decisions

Researchers discover way to reverse brain aging caused by COVID-19

New organoid model could lead to personalized treatments for colon-related diseases

Uncontrolled growth as a cancer cell's weakness

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Stand Up To Cancer unveils new gastroesophageal cancer research teams and awards

Microglia found to play crucial role in early human brain development

Crown Bioscience launches large-scale organoid panel screening platform for accelerated preclinical oncology drug discovery

Study reveals early role of SYNGAP1 gene in brain development

Gut bacteria promote social behavior and wound healing through oxytocin signaling

Study sheds light on origins of breast cancer in people with BRCA2 mutations

UniSA seeks public support for vital research on deadly brain cancers

New insights into the molecular basis of schizophrenia during early brain development

Lactobacillus iners in tumors: Driving chemoradiation resistance via lactate-induced metabolic rewiring

Low serotonin levels observed in long COVID and other viral infections

Microscale device for eye implantation may be used in the treatment of diabetes

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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