Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Novel drug combination shows promise in treating pancreatic cancer

Mutations in the KRAS gene are the major driver of pancreatic cancer. The resulting protein controls multiple signaling pathways involved in cell growth and survival. In cancer, the gene is mutated to be permanently "on," driving cells to excessively multiply and form tumors.

28 Jun 2023

3D models of ovarian cancer reveal how cell’s location can affect tumor biology

Using 3-D models of ovarian cancer tumors, scientists found differences in gene activity based on where a cell is in a tumor, demonstrating how a cell's location and environment in a cancerous tumor can strongly influence which genes are active and the cell's role in the cancer's biology.

23 Jun 2023

Brain organoids provide new insights into HSV-1 encephalitis

The herpes simplex virus-1 can sometimes cause a dangerous brain infection. Combining an anti-inflammatory and an antiviral could help in these cases, report scientists with the Rajewsky and Landthaler labs and the Organoid Platform at the Max Delbrück Center in Nature Microbiology.

22 Jun 2023

Researchers use an unprecedented stem cell zoo to study developmental time

In humans, pregnancy lasts around nine months. In mice, only 20 days, and in rhinoceroses, as long as 17 months. Although many mammalian species go through the same stages during embryo development, the speed of development differs substantially across animals.

20 Jun 2023

Unveiling ancient minds: fossil endocasts unlock secrets of past brains

Study summarized the knowledge of brain anatomy from fossil records and brain evolution.

15 Jun 2023

Scientists uncover the structure of the first step in amyloid formation for Huntington's disease

Devastating neurodegenerative diseases like Huntington's, Alzheimer's, and Parkinson's are all associated with protein deposits in the brain, known as amyloid.

13 Jun 2023

New cell culture model generates the alveolar macrophage in the lab

Researchers at Texas Biomedical Research Institute have succeeded in generating the lung's most important immune cell, the alveolar macrophage, in the lab.

12 Jun 2023

Mechanistic insights into how the SARS-CoV-2 virus affects the nervous system, alters its function, and causes neuropathology

Study demonstrates that SARS-CoV-2 infection and viral fusogens cause glial and neuronal fusion.

9 Jun 2023

Weak spot discovery could pave way for more effective cancer therapies

Prostate cancer is the most common non-skin cancer in men worldwide. According to international estimates about one in six men will get prostate cancer during their lifetime and worldwide, over 375'000 patients will die from it each year.

8 Jun 2023

New strategy to grow and measure how tumor organoids respond to therapy

Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors. The improved process allows researchers to use an advanced imaging method to study and analyze individual organoids in great detail, which can help researchers identify personalized treatments for people with rare or hard-to-treat cancers.

7 Jun 2023

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

Targeting stem cells from the human stomach for treating diabetes

Stem cells from the human stomach can be converted into cells that secrete insulin in response to rising blood sugar levels, offering a promising approach to treating diabetes, according to a preclinical study from researchers at Weill Cornell Medicine.

25 May 2023

Organoids News and Research

Further Reading

Novel drug combination shows promise in treating pancreatic cancer

3D models of ovarian cancer reveal how cell’s location can affect tumor biology

Brain organoids provide new insights into HSV-1 encephalitis

Researchers use an unprecedented stem cell zoo to study developmental time

Unveiling ancient minds: fossil endocasts unlock secrets of past brains

Scientists uncover the structure of the first step in amyloid formation for Huntington's disease

New cell culture model generates the alveolar macrophage in the lab

Mechanistic insights into how the SARS-CoV-2 virus affects the nervous system, alters its function, and causes neuropathology

Weak spot discovery could pave way for more effective cancer therapies

New strategy to grow and measure how tumor organoids respond to therapy

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Targeting stem cells from the human stomach for treating diabetes

The role of RNA splicing in one of the deadliest forms of pancreatic cancer

Patient-derived head and neck cancer organoids could aid the discovery of novel therapies

New CRISPR genome-editing technology helps scientists to explore many cancer-linked mutations

High-resolution atlas illustrates the development of human retina

Organoids derived from cancer cells can reduce the need for trial and error in identifying effective treatments

Organoid models provide new scientific insights into a rare childhood liver cancer

Mechanism to protect the liver from destruction in case of obesity revealed

Researchers explore the role of a genetic process in pancreatic cancer

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

Uniting Against Resistance: The World Health Organization for World Antimicrobial Awareness Week 2023

Tackling Antimicrobial Resistance: A Conversation with Dr. Beverley Isherwood

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