Oxidative Stress News and Research

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Oxidative Stress is a condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma.

Researchers determine mechanism of action of chemotherapy drug motexafin gadolinium

The chemotherapy drug motexafin gadolinium (brand name: Xcytrin, manufactured by Pharmacyclics, Inc.) works to thwart cancer cells by disrupting key enzymes involved in cellular metabolism, according to a team of researchers led by Joseph Hacia, Ph.D., assistant professor of biochemistry and molecular biology at the Keck School of Medicine of the University of Southern California.

1 May 2005

Fickle enzyme helps protect, but also can promote heart failure

Enzymes that make the gas nitric oxide (NO) not only protect the heart from damage due to high blood pressure or a heart attack, but also promote heart failure through overgrowth and enlargement of the muscle tissue, say animal researchers at Johns Hopkins.

26 Apr 2005

Obesity and insulin resistance fuels cardiovascular risk factors in teens

Obesity and insulin resistance are a menacing tag team that fuels cardiovascular risk factors in teens, according to a study reported in an obesity-themed issue of Circulation: Journal of the American Heart Association.

23 Apr 2005

Alternate view for pathology of Alzheimer's disease

A new paper from researchers at the Case Western Reserve University School of Medicine challenges the classic theory that the nerve tangles seen in the brains of Alzheimer's disease (AD) victims are the cause of the disease, but rather proposes that they are a protective response to the disease. Their paper appears in the April issue of the journal Trends in Molecular Medicine.

19 Apr 2005

Cardiovascular disease: diet, nutrition and emerging risk factors

Despite improvements in death rates from cardiovascular disease (CVD) around the world, CVD remains a leading cause of death and ill health in the UK, where death rates are amongst the highest in the world. Reducing death rates from this disease remains high on the Government’s agenda, yet attention to the classical risk factors may not provide all the answers.

12 Apr 2005

Hemodialysis causes antioxidant loss leading to long-term complications

An article published in Hemodialysis International discusses the role of oxidative stress (OS) in dialysis patients, an imbalance which can result in long-term health problems. Potential therapeutic options to restore balance in patients are also reviewed.

10 Apr 2005

Role of oxidative stress (OS) in dialysis patients

7 Apr 2005

Autistic children found to have abnormal metabolic profile

Autism, a neurodevelopment disorder which has increased tenfold over the last 15 years, now affects 30 of every 10,000 children in the United States.

4 Apr 2005

Children with autism have a severely abnormal metabolic profile

Chronic biochemical imbalance is often a primary factor in the development of many complex diseases but a possible metabolic basis for autism has not been well explored. Now Arkansas Children's Hospital Research Institute researchers report for the first time that children with autism have a severely abnormal metabolic profile indicating increased vulnerability to oxidative stress.

3 Apr 2005

Hemodialysis causes antioxidant loss leading to long-term complications

30 Mar 2005

Molecule that causes secondary stroke

Scientists at the University of Cincinnati (UC) College of Medicine have discovered the cause of a deadly type of secondary stroke known as cerebral vasospasm.

28 Mar 2005

Pomegranate juice helps keep fatty deposits from collecting on artery walls

A study in the current issue of the Proceedings of the National Academy of Sciences, by Italian and American scientists reports that pomegranate juice helped keep fatty deposits from collecting on artery walls in mice, and kept human heart cells healthier. The mice were specially bred to have high cholesterol and on human heart cells in culture.

22 Mar 2005

Compound found in broccoli is a powerful disease fighter

More than 300 scientific studies point to an antioxidant found in broccoli sprouts, sulforaphane glucosinolate (SGS), as a factor in preventing multiple diseases, including several types of cancer, high blood pressure, macular degeneration and stomach ulcers.

21 Mar 2005

Selenium, vitamin E and the tomato nutrient lycopene have been shown to reduce prostate cancer

Greater levels of selenium, vitamin E and the tomato nutrient lycopene have been shown to reduce prostate cancer in one out of every four Caucasian males - those who inherit a specific genetic variation that's particularly sensitive to oxidative stress.

15 Mar 2005

Olmesartan improves blood supply to kidneys

How do medications that block the renin-angiotensin system (RAS blockers) work to protect against kidney disease in people with diabetes? At least partly by improving the blood supply to the kidneys, suggests a study in the April Journal of the American Society of Nephrology.

17 Feb 2005

Genetic manipulation cuts nerve damage, boosts life span

A novel genetic manipulation significantly extends the life spans of flies by reducing the amount of wear and tear suffered by nerve cells in adults, according to new work published in Cell Metabolism. The findings support the idea that therapies designed to protect the adult nervous system by curbing the production of damaging free radicals might effectively increase longevity in other animals, including humans, the researchers said.

15 Feb 2005