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Scientists deploy CRISPR gene-editing tool to engineer multiple edits

Scientists at Christiana Care Health System's Gene Editing Institute and NovellusDx, an Israeli biotechnology company, have deployed a breakthrough CRISPR gene-editing tool to successfully engineer multiple edits simultaneously to fragments of DNA extracted from a human cell, according to a new study published today in The CRISPR Journal.

19 Apr 2019

CRISPR may restore effectiveness of chemotherapies used to treat lung cancer

The CRISPR-Cas9 gene editing system may be able to restore the effectiveness of first-line chemotherapies used to treat lung cancer by deleting or "knocking out" a gene in cancer tumors that helps the tumors develop resistance to the drugs.

18 Dec 2018

New discovery will improve the safety and predictability of CRISPR

Scientists have discovered a simple set of rules that can be used to precisely predict how DNA will be modified by the CRISPR gene editing technique.

13 Dec 2018

CRISPR genome editing has foreseeable implications for plastic and reconstructive surgery

The CRISPR genome editing technique promises to be a "transformative leap" in genetic engineering and therapy, affecting almost every area of medicine.

31 Oct 2018

Genetically modifying zebrafish provides numerous, highly accurate disease models

Research published today describes how zebrafish can be genetically engineered to produce more accurate models of human disease.

18 Oct 2018

Researchers to study the use of CRISPR on human liver on-a-chip platform

Two Arizona State University professors are among the first recipients of Somatic Cell Genome Editing grants from the National Institutes of Health Common Fund. The $2,600,000, five-year grant will fund the first study of the genome editing technology CRISPR to be used on a "human liver on-a-chip" platform.

15 Oct 2018

Scientists identify new biomarker for Alzheimer's disease of sporadic origin

The objective of the research, undertaken in the laboratories of the IBPM, is to develop a model for studying Alzheimer's disease of sporadic origin, in other words, not due to a hereditary genetic mutation.

10 Oct 2018

Researchers present evidence of phage cooperation when attacking CRISPR-containing bacteria

CRISPR, or clustered regularly interspaced short palindromic repeats, are an essential part of bacterial immunity designed to defend against foreign DNA. In bacteria, CRISPR acts just like it does in human cells as a pair of scissors, in their case with the goal of cutting strands of infecting DNA.

20 Jul 2018

CRISPR-based treatment can restore retinal function in mice with eye disease

Researchers from Columbia University have developed a new technique for the powerful gene editing tool CRISPR to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa.

11 May 2018

Scientists use CRISPR tool to make multiple edits to DNA samples 'in vitro'

Scientists at Christiana Care Health System's Gene Editing Institute have developed a potentially breakthrough CRISPR gene-editing tool. It could allow researchers to take fragments of DNA extracted from human cells, put them into a test tube, and quickly and precisely engineer multiple changes to the genetic code, according to a new study published today in the CRISPR Journal.

20 Apr 2018

CRISPR enzyme can also cleave RNA, finds study

Researchers have discovered that the Cas-9 enzyme used in CRISPR gene editing can also cleave complimentary messenger RNA, in addition to DNA.

2 Mar 2018

Gene editing tool used to detect cancer

Researchers have developed a DNA detection system that can detect the presence of bacterial and viral DNA, which could be a valuable diagnostic tool for a range of disorders.

16 Feb 2018

New microcapsules represent promising vectors for application of genome-editing tools

Researchers from Tomsk Polytechnic University jointly with their colleagues from St. Petersburg, Hamburg and London have conducted a study in the course of which it was found out that polymer and hybrid silica-coated microcapsules are more efficient in genome-editing when applying CRISPR-Cas9 system.

6 Oct 2017

Study shows new method for repairing disease-causing mutation in human embryos

Scientists have demonstrated an effective way of using a gene-editing tool to correct a disease-causing gene mutation in human embryos and stop it from passing to future generations.

3 Aug 2017

Expert highlights CRISPR’s applications, limitations, and ethical concerns

"Good morning, doctor, I am here for my gene editing appointment." In the future, could this be a greeting heard in physician offices around the world? With the introduction of CRISPR technology, genetic material can now be more easily and precisely edited, even creating changes that can subsequently be inherited by offspring.

1 Aug 2017

Researchers use gene-editing technique to develop new screening tool for Parkinson's disease

A team of researchers at the University of Central Florida is using breakthrough gene-editing technology to develop a new screening tool for Parkinson's disease, a debilitating degenerative disorder of the nervous system.

5 Jun 2017

Researchers use gene-editing tool to restore visual function in mouse models of retinitis pigmentosa

Using the gene-editing tool CRISPR/Cas9, researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health, with colleagues in China, have reprogrammed mutated rod photoreceptors to become functioning cone photoreceptors, reversing cellular degeneration and restoring visual function in two mouse models of retinitis pigmentosa.

21 Apr 2017

TSRI researchers reveal how viruses incapacitate bacterial defense system

Picture bacteria and viruses locked in an arms race. For many bacteria, one line of defense against viral infection is a sophisticated RNA-guided "immune system" called CRISPR-Cas.

28 Mar 2017

Study findings could lead to novel therapies for preventing vision loss from degenerative retinal diseases

Silencing a gene called Nrl in mice prevents the loss of cells from degenerative diseases of the retina, according to a new study.

15 Mar 2017

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

CRISPR/Cas9 genome editing is quickly revolutionizing biomedical research, but the new technology is not yet exact. The technique can inadvertently make excessive or unwanted changes in the genome and create off-target mutations, limiting safety and efficacy in therapeutic applications.

9 Dec 2016