Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.

3 Jan 2024

Study maps gene network orchestrating complex process of IgG glycosylation in aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 24, entitled, "Mapping of the gene network that regulates glycan clock of ageing."

3 Jan 2024

Previously unidentified protein variant shields against Parkinson's disease

A previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study.

2 Jan 2024

New AI tool spotlights hidden cancers for better diagnosis

A new artificial intelligence tool that interprets medical images with unprecedented clarity does so in a way that could allow time-strapped clinicians to dedicate their attention to critical aspects of disease diagnosis and image interpretation.

2 Jan 2024

Healthy aging modulates the neural oscillatory dynamics serving working memory function

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 24, entitled, "Age-related alterations in the oscillatory dynamics serving verbal working memory processing."

2 Jan 2024

Study identifies α-MSH as therapeutic candidate for corneal endothelial disease

Findings from a pioneering study in The American Journal of Pathology, published by Elsevier, reveal that administration of the neuropeptide α-melanocyte-stimulating hormone (α-MSH) promotes corneal healing and restores normal eye function to an otherwise degenerating and diseased cornea by providing protection against cell death and promoting cell regeneration.

2 Jan 2024

Small molecule-switchable RNA platform enables control of therapeutic protein expression

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window.

2 Jan 2024

Angelica gigas extract emerges as a potential treatment for vascular disease

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction."

28 Dec 2023

Common inflammation pathway turns anthrax toxin into killer

Bacillus anthracis lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system.

26 Dec 2023

Increased β-amyloid accumulation may be linked to Alzheimer’s dementia risk in oldest of the old

A new study indicates that severity of amyloid deposition in the brain -; not just age -; may be key to determining who will benefit from new anti-amyloid therapies to delay the progression of Alzheimer's disease.

26 Dec 2023

UCLA researchers receive $3 million to develop AI for aggressive prostate cancer detection

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have received a five-year, $3 million grant from the National Cancer Institute to identify novel cancer biomarkers and develop AI that can detect and predict aggressive prostate cancer to help avoid unnecessary treatments and their associated negative side effects.

21 Dec 2023

Study points to senolytic drugs as potential weapon against lung emphysema

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema."

20 Dec 2023

$2.4 million grant to fund project PAL for building diversity in speech-language pathology

The Department of Audiology and Speech Pathology at the University of Tennessee Health Science Center and the Department of Hearing and Speech Sciences at Vanderbilt University have secured a $2,399,454 grant to fund a five-year project to address the need for diversity in highly trained professionals in speech-language pathology.

20 Dec 2023

New study pinpoints mitochondria as key player in dietary fat-cancer connection

The research study is entitled "The Central Role of Mitochondria in the Relationship between Dietary Lipids and Cancer Progression". It revealed new findings on the factors that influence the development of diseases, such as the particularly interesting relationship between dietary fats and the development of cancer.

20 Dec 2023

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

A surprising MIT study published in Nature at the end of 2016 helped to spur interest in the possibility that light flickering at the frequency of a particular gamma-band brain rhythm could produce meaningful therapeutic effects for people with Alzheimer's disease.

20 Dec 2023

Endometrial cancer rates rising alarmingly, particularly among Black women

The numbers are stark and deeply troubling. Endometrial cancer -; which develops in the lining of the uterus (womb) and is sometimes called uterine cancer -; is on the rise in the U.S. In 1987, there were 35,000 cases annually.

19 Dec 2023

Autopsy study provides new insights into yellow fever's impact on the heart

To fill gaps in knowledge of yellow fever (YF), a group of researchers in Brazil affiliated with the Department of Pathology at the University of São Paulo's Medical School (FM-USP), Hospital das Clínicas (HC, the hospital complex run by FM-USP), the Heart Institute (InCor, linked to HC) and Emílio Ribas Institute of Infectious Diseases (IIER) decided to study the pathogenesis of YF-associated heart injury.

19 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

Sirtuin 6: A potential savior for aging cartilage and osteoarthritis

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes."

19 Dec 2023

First case of COVID-caused vocal cord paralysis in teen reported by Mass Eye and Ear doctors

Physician-researchers from Mass Eye and Ear, a member of Mass General Brigham, report the first pediatric case of bilateral vocal cord paralysis after COVID-19 (SARS-CoV-2) infection.

19 Dec 2023

Pathology News and Research

Further Reading

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

Study maps gene network orchestrating complex process of IgG glycosylation in aging

Previously unidentified protein variant shields against Parkinson's disease

New AI tool spotlights hidden cancers for better diagnosis

Healthy aging modulates the neural oscillatory dynamics serving working memory function

Study identifies α-MSH as therapeutic candidate for corneal endothelial disease

Small molecule-switchable RNA platform enables control of therapeutic protein expression

Angelica gigas extract emerges as a potential treatment for vascular disease

Common inflammation pathway turns anthrax toxin into killer

Increased β-amyloid accumulation may be linked to Alzheimer’s dementia risk in oldest of the old

UCLA researchers receive $3 million to develop AI for aggressive prostate cancer detection

Study points to senolytic drugs as potential weapon against lung emphysema

$2.4 million grant to fund project PAL for building diversity in speech-language pathology

New study pinpoints mitochondria as key player in dietary fat-cancer connection

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

Endometrial cancer rates rising alarmingly, particularly among Black women

Autopsy study provides new insights into yellow fever's impact on the heart

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Sirtuin 6: A potential savior for aging cartilage and osteoarthritis

First case of COVID-caused vocal cord paralysis in teen reported by Mass Eye and Ear doctors

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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