Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Novel method identifies new oncogene that contributes to development of cancer

A team of researchers at Case Western Reserve University School of Medicine, led by Dr. Mark W. Jackson, have developed a novel method to identify genes that, when overexpressed, make normal cells behave like cancer cells.

14 Aug 2012

Scientists identify new genetic alterations underlying high-risk subtype of ALL

Scientists have identified new genetic alterations underlying a high-risk subtype of the most common childhood cancer that could be effectively targeted with existing leukemia therapies.

14 Aug 2012

Ingredient for butter flavor in microwave popcorn is a respiratory hazard

The ingredient 2,3-pentanedione (PD), used to impart the flavor and aroma of butter in microwave popcorn, is a respiratory hazard that can also alter gene expression in the brain of rats. Manufacturers started using PD when another butter flavoring, diacetyl, was found to cause bronchiolitis obliterans, a life-threatening and nonreversible lung disease in workers who inhaled the substance.

13 Aug 2012

Carnegie Mellon University awarded CURE grant by the Pennsylvania Department of Health

Pennsylvania Department of Health Executive Deputy Secretary Michael Wolf today presented a Commonwealth Universal Research Enhancement Program, or CURE, grant to Carnegie Mellon University. The $983,783 grant will be used for a two-year research project focused on cancer treatment technologies.

13 Aug 2012

Latrepirdine demonstrates new potential against neurodegenerative conditions

The second of two studies on latrepirdine, recently published in Molecular Psychiatry, demonstrates new potential for the compound in the treatment of Alzheimer's disease, Parkinson's disease, sleep disorders, and other neurodegenerative conditions. An international team led by Mount Sinai School of Medicine scientists found that latrepiridine, known commercially as Dimebon, reduced the level of at least two neurodegeneration-related proteins in mice.

13 Aug 2012

New 3-D view of the body's response to infection

A new 3-D view of the body's response to infection - and the ability to identify proteins involved in the response - could point to novel biomarkers and therapeutic agents for infectious diseases.

13 Aug 2012

Effects on white matter brain volume from long-term alcoholism are different for men and women

(Boston) - Researchers from Boston University School of Medicine (BUSM) and Veterans Affairs (VA) Boston Healthcare System have demonstrated that the effects on white matter brain volume from long-term alcohol abuse are different for men and women. The study, which is published online in Alcoholism: Clinical and Experimental Research, also suggests that with abstinence, women recover their white matter brain volume more quickly than men.

12 Aug 2012

New subtype of Ewing sarcoma discovered

A new study of the genetic makeup, or genome, of Ewing sarcoma, a rare cancer that strikes children, teenagers, and young adults, has produced multiple discoveries: a previously unknown sarcoma subtype, genetic factors related to long-term survival, and identification of a genetic change between the primary and metastatic stages of the disease that could lead to better, more targeted treatment.

10 Aug 2012

Borderline personality disorder ‘not linked to psychosis transition’

The presence of borderline personality disorder is not associated with an increased risk for transition to full-blown psychosis in ultra-high risk patients, research shows.

9 Aug 2012

Interface zone fibroblasts play key role in gastric cancer

Interface zone fibroblasts in gastric adenocarcinoma promote the invasion, migration, and proliferation of cancer cells, as well as prevent apoptosis, to a greater degree than normal or tumor zone fibroblasts, say researchers.

8 Aug 2012

Roundup: Ky. judge to hear Christians-only health insurer case

A judge has scheduled a hearing for later this month in a longstanding dispute between Kentucky and a Christians-only health care plan. The case pits the Kentucky Department of Insurance against Medi-Share, a Florida-based cost-sharing ministry that helps to pay medical bills for churchgoers across the country.

8 Aug 2012

RCPA’s new factsheets to breakdown the mystery of pathology

Pathology is a section of the healthcare system that takes place behind the scenes, tucked away in laboratories and, as a result, is an area of medicine that is largely misunderstood. Often pathology can open up a plethora of questions such as: why do I need a pathology test; where can I have a test; how safe is the testing; how is a pathology test fee calculated; and how should I go about genetic testing?

7 Aug 2012

Borderline personality disorder ‘not linked to psychosis transition’

The presence of borderline personality disorder is not associated with an increased risk for transition to full-blown psychosis in ultra-high risk patients, research shows.

7 Aug 2012

New analysis provides overall genetic fingerprint of various Jewish subpopulations

A new genetic analysis focusing on Jews from North Africa has provided an overall genetic map of the Jewish Diasporas. The findings support the historical record of Middle Eastern Jews settling in North Africa during Classical Antiquity, proselytizing and marrying local populations, and, in the process, forming distinct populations that stayed largely intact for more than 2,000 years.

7 Aug 2012

Topline results from Janssen bapineuzumab Phase 3 trial on mild-to-moderate Alzheimer's

Pfizer Inc. announced today that the co-primary clinical endpoints, change in cognitive and functional performance compared to placebo, were not met in the Janssen Alzheimer Immunotherapy R&D LLC (Janssen AI)-led Phase 3 trial of intravenous (IV) bapineuzumab in patients with mild-to-moderate Alzheimer's disease who do not carry the ApoE4 (apolipoprotein E epsilon 4) genotype (Study 301).

7 Aug 2012

Potential drug targets and prognostic markers for prostate cancer

Two proteins that act in opposing directions - one that promotes cancer and one that suppresses cancer - regulate the same set of genes in prostate cancer, Vanderbilt-Ingram Cancer Center researchers have found.

6 Aug 2012

New research center to expedite study of gene transfer approach

In an alliance aimed at bringing a new, personalized immunotherapy approach to patients with a wide variety of cancers, the University of Pennsylvania and Novartis announced today an exclusive global research and licensing agreement to further study and commercialize novel cellular immunotherapies using chimeric antigen receptor (CAR) technologies.

6 Aug 2012

NeoGenomics introduces new molecular assay that detects SF3B1 gene mutations

NeoGenomics, Inc., a leading provider of cancer-focused genetic testing services, announced today that it has validated and launched the first molecular assay for clinical use in the United States that detects mutations in the SF3B1 gene (splicing factor 3b, subunit 1).

6 Aug 2012

Common ragweed may induce airways irritation through terpenoids

Allergy to pollen of common ragweed is increasingly affecting patients and is second only to grass pollen in terms of incidence in the general population of many European countries.

6 Aug 2012

Researchers make major advance in efforts to regenerate damaged hearts

Researchers have made a major advance in efforts to regenerate damaged hearts. Grafts of human cardiac muscle cells, grown from embryonic stem cells, coupled electrically and contracted synchronously with host muscle following transplantation in guinea pig hearts.

6 Aug 2012