Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Study demonstrates role of alpha-synuclein cell-to-cell transfer in Parkinson's disease pathogenesis

The misfolding of abnormal proteins in brain cells is a key element in Parkinson's disease development. A recent study suggests that the sick proteins slowly move between cells, eventually triggering the destruction of the new host cell. The discovery could potentially lead to new therapeutic strategies for neurodegenerative diseases aimed at blocking the spread of protein misfolding throughout the brain.

19 Jan 2011

UNC scientists discover how chaperone enzyme plays a key role in cells' ability to tolerate DNA damage

UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads to cancer and other diseases.

19 Jan 2011

New patented technique offers unprecedented view of DNA damage

New technology providing the first view of DNA damage throughout the entire human genome developed by Cardiff University scientists could offer a valuable new insight into the development and treatment of conditions like cancer.

19 Jan 2011

Lower levels in plasma of biomarkers beta-amyloid 42/40 increase rate of cognitive decline

Older adults without dementia and with lower levels in plasma of the biomarkers beta-amyloid 42/40 (protein fragments) had an increased rate of cognitive decline over a period of 9 years, according to a study in the January 19 issue of JAMA. The researchers also found that this relationship was stronger among individuals with less education and lower levels of literacy.

19 Jan 2011

BSi and OMJPI enter development agreement for novel neurological and psychiatric disease therapeutics

The Johns Hopkins Brain Science Institute (BSi) announced today that it has entered into an agreement with Ortho-McNeil-Janssen Pharmaceuticals Inc. (OMJPI) to advance the development of novel therapeutics for neurological and psychiatric diseases.

19 Jan 2011

Molecular imaging procedure may detect beta-amyloid in brain, increase accuracy of AD diagnosis

Preliminary research suggests that use of a type of molecular imaging procedure may have the ability to detect the presence of beta-amyloid in the brains of individuals during life, a biomarker that is identified during autopsy to confirm a diagnosis of Alzheimer disease, according to a study in the January 19 issue of JAMA.

19 Jan 2011

AMBR sensor measures growth and drug susceptibility of bacterial cells without use of microscope

With an invention that can be made from some of the same parts used in CD players, University of Michigan researchers have developed a way to measure the growth and drug susceptibility of individual bacterial cells without the use of a microscope.

19 Jan 2011

PAM50 test is now available to classify breast cancer subtypes

ARUP Laboratories, a leading national clinical and anatomic pathology reference laboratory and a leader in innovative laboratory research and development, today announced the availability of a new laboratory developed test designed to classify breast cancer into clinically significant molecular subtypes that are important for the management of the disease.

18 Jan 2011

iBio grants commercial, royalty-bearing license to Fiocruz/Bio-Manguinhos for new yellow fever vaccine

iBio, Inc. today announced the grant of a commercial, royalty-bearing license to Fiocruz/Bio-Manguinhos of Brazil to develop, manufacture and sell certain vaccines based upon iBio's proprietary technology. Fiocruz/Bio-Manguinhos will invest more than $6 million to bring the first product - a new yellow fever vaccine - through Phase I clinical trials.

18 Jan 2011

Healthcare Information Xchange of New York completes implementation of InterSystems HealthShare HIE platform

InterSystems Corporation, the global leader in software for connected health care, today announced that the Healthcare Information Xchange of New York (HIXNY) has completed implementation of InterSystems HealthShare™ as its core health information exchange (HIE) platform.

18 Jan 2011

Researchers present new findings on role of relationship between patient and therapist

This study published in the last 2010 issue of Psychotherapy and Psychosomatics suggests that therapist and patient ratings of therapeutic alliance predict therapeutic progress.

18 Jan 2011

Scientists demonstrate mechanism that explains why PSA levels promote prostate cancer

Researchers at the Duke Cancer Institute who have been studying prostate cancer cells for decades now think they know why PSA levels reflect cancer progression.

14 Jan 2011

Genetic information from Guthrie cards may serve as valuable resource to diagnose infant diseases

Van Andel Research Institute researchers have developed a method that can yield more information from archived newborn blood that has implications for a vast array of research, including population health studies and answering questions about diseases in infants and children.

13 Jan 2011

Study highlights important clinical implications of miR-503 in diabetes-associated vascular complications

New research has found one of the smallest entities in the human genome, micro-RNA, could increase the risk of limb amputation in diabetic patients who have poor blood flow.

13 Jan 2011

Study indicates disease's underlying causes in mice, finds compounds that normalize Alzheimer's brain

A Blanchette Rockefeller Neurosciences Institute study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States.

12 Jan 2011

Study reveals underlying causes for degeneration of synapses in Alzheimer's Disease

A Blanchette Rockefeller Neurosciences Institute (BRNI) study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States.

12 Jan 2011

How chlamydia increases risk of ectopic pregnancy

Women who have had chlamydia are at greater risk of an ectopic pregnancy because of a lasting effect of the infection.

11 Jan 2011

Bone marrow stem cell transplantation provides therapeutic benefit to patients with end-stage liver disease

Transplanting their own bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation. Yet, the mechanism by which the infusion of CD34+ stem cells improves liver function remains elusive, they say.

11 Jan 2011

Qui Tam case against NeoGenomics dismissed with prejudice

NeoGenomics, Inc. announced today that it has been notified that the Qui Tam complaint filed against it and several other healthcare companies in 2009 has been voluntarily dismissed with prejudice by the relator in the case. As a result, no further action will be taken against NeoGenomics in this matter.

11 Jan 2011

Haiti teen to undergo open-heart surgery at Montefiore

Mahalia Desruisseaux, M.D., assistant professor of pathology and of medicine at Albert Einstein College of Medicine of Yeshiva University who had traveled to Haiti to assist in the relief effort, identified a serious heart condition. Now, one year later, Ms. Ajuste will undergo open-heart surgery at Montefiore, The University Hospital and Academic Medical Center for Einstein, to correct the defect.

11 Jan 2011

Pathology News and Research

Further Reading

Study demonstrates role of alpha-synuclein cell-to-cell transfer in Parkinson's disease pathogenesis

UNC scientists discover how chaperone enzyme plays a key role in cells' ability to tolerate DNA damage

New patented technique offers unprecedented view of DNA damage

Lower levels in plasma of biomarkers beta-amyloid 42/40 increase rate of cognitive decline

BSi and OMJPI enter development agreement for novel neurological and psychiatric disease therapeutics

Molecular imaging procedure may detect beta-amyloid in brain, increase accuracy of AD diagnosis

AMBR sensor measures growth and drug susceptibility of bacterial cells without use of microscope

PAM50 test is now available to classify breast cancer subtypes

iBio grants commercial, royalty-bearing license to Fiocruz/Bio-Manguinhos for new yellow fever vaccine

Healthcare Information Xchange of New York completes implementation of InterSystems HealthShare HIE platform

Researchers present new findings on role of relationship between patient and therapist

Scientists demonstrate mechanism that explains why PSA levels promote prostate cancer

Genetic information from Guthrie cards may serve as valuable resource to diagnose infant diseases

Study highlights important clinical implications of miR-503 in diabetes-associated vascular complications

Study indicates disease's underlying causes in mice, finds compounds that normalize Alzheimer's brain

Study reveals underlying causes for degeneration of synapses in Alzheimer's Disease

How chlamydia increases risk of ectopic pregnancy

Bone marrow stem cell transplantation provides therapeutic benefit to patients with end-stage liver disease

Qui Tam case against NeoGenomics dismissed with prejudice

Haiti teen to undergo open-heart surgery at Montefiore

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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