Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Store-and-forward telemedicine as effective as in-person evaluation for planning ear surgery: Study

The 2010 Annual Meeting & OTO EXPO of the American Academy of Otolaryngology - Head and Neck Surgery Foundation,the largest meeting of ear, nose, and throat doctors in the world, will convene September 26-29, in Boston, MA. The official abstract supplement for the annual meeting is now available with the regular August 2010 issue of Otolaryngology - Head and Neck Surgery.

2 Aug 2010

AMP conducts survey on Genetic Test Registry

Today, the Association for Molecular Pathology (AMP) submitted written comments in response to the Request for Information made by the National Institutes of Health (NIH) for its Genetic Test Registry (GTR). AMP conducted a survey of its membership to formulate a comprehensive response to the RFI. "With the vast majority of respondents working in a clinical laboratory setting, AMP is able to inform the NIH on the general reaction to the GTR, including insight to the community's concerns and guidance to ensure the GTR is a valued resource," said Dr. Karen Mann, President of AMP.

31 Jul 2010

Epigenetic changes to DNA in breast cancers linked with environmental risk factors, tumor size: Study

Researchers from Brown University and the University of California San Francisco have found that epigenetic changes to DNA in breast cancers are related to environmental risk factors and tumor size, providing a window into the severity of the disease. The study is published in today's edition of PLoS Genetics. The researchers found that epigenetic profiles of tumors had a direct association with diet, alcohol, and tumor size.

31 Jul 2010

FDA lifts hold, allows Geron to proceed with Phase I clinical trial of GRNOPC1 in spinal cord injury

Geron Corporation announced today that the U.S. Food and Drug Administration (FDA) has notified the company that the clinical hold placed on Geron's Investigational New Drug (IND) application has been lifted and the company's Phase I clinical trial of GRNOPC1 in patients with acute spinal cord injury may proceed.

30 Jul 2010

Despite all advancements in melanoma diagnosis, rapid treatment remains critical: Report

Twenty-five years after publishing the mnemonic "ABCD" to facilitate the early diagnosis of melanoma, the group who came up with that moniker says early detection remains a key factor in lowering mortality from malignant melanoma. Darrell S. Rigel, M.D. and colleagues from the Ronald O. Perelman Department of Dermatology at New York University School of Medicine say that, despite all of the advances in melanoma diagnosis, timely recognition, detection, and rapid treatment of melanoma remain critical.

30 Jul 2010

Researchers discover tumor suppressor lincRNAs

The recent discovery of more than a thousand genes known as large intergenic non-coding RNAs (or "lincRNAs") opened up a new approach to understanding the function and organization of the genome. That surprising breakthrough is now made even more compelling with the finding that dozens of these lincRNAs are induced by p53 (the most commonly mutated gene in cancer), suggesting that this class of genes plays a critical role in cell development and regulation. Furthermore, the researchers identify one lincRNA in particular (lincRNA-p21), and demonstrate its critical role in suppressing the reading of many genes across the genome following p53 activation.

30 Jul 2010

NeoGenomics second-quarter 2010 revenue increases 14% to $8.5 million

NeoGenomics, Inc., a leading provider of cancer-focused genetic testing services today reported its results for the second quarter 2010.

29 Jul 2010

Safeguard Scientifics second-quarter aggregate revenue of partner companies increase 47% to $91.6 million

Safeguard Scientifics, Inc., a holding company that builds value in growth-stage life sciences and technology companies, today announced that aggregate revenue of its partner companies for the three months ended June 30, 2010 was $91.6 million, up 47% from $62.3 million for the same partner companies in the same period of 2009. For the six months ended June 30, 2010, the aggregate partner company revenue was $176.9 million, up 45% from $121.8 million for the same partner companies for the same period of 2009.

29 Jul 2010

Clarient second-quarter net revenue increases 21% to $28.7 million

Clarient, Inc., a premier anatomic pathology and molecular testing services resource for pathologists, oncologists and the biopharmaceutical industry, today reported financial results for the second quarter ended June 30, 2010. Second quarter 2010 net revenue was $28.7 million, a 21 percent increase over the $23.7 million net revenue in the 2009 second quarter and a sequential increase of nearly eight percent over the $26.6 million in the first quarter of 2010.

29 Jul 2010

Scientists identify new targets to develop treatment for HD

Scientists at the Buck Institute for Age Research have discovered that a particular family of enzymes are involved in the breakdown of proteins that modify the production of toxic fragments that lead to the pathology of Huntington's disease. These enzymes, matrix metalloproteinases, provide new targets for drug therapies for the disease - targets that have already been shown to respond to cancer drugs currently in clinical development.

29 Jul 2010

NDS Surgical Imaging introduces ConnectOR G2 visualization and informatics platform

NDS Surgical Imaging (NDSsi) today launched its next-generation visualization and informatics platform—the ConnectOR G2—with production units now shipping to customers. Based on the NDSsi technology vision of Medical Visualization Informatics (MVI), ConnectOR G2 medical-grade products are leading the industry in procedural efficacy by offering the unique ability to connect the realms of PACS imaging, surgical video and medical informatics.

29 Jul 2010

Loss of key nerve cells cause Parkinson's disease: Research

Scientists at the Stanford University School of Medicine have identified a molecular pathway responsible for the death of key nerve cells whose loss causes Parkinson's disease. This discovery not only may explain how a genetic mutation linked to Parkinson's causes the cells' death, but could also open the door to new therapeutic approaches for the malady.

29 Jul 2010

Inhibition of MMPs can offer therapeutic benefit in Huntington's disease: Study

A new study reveals that an enzyme linked with multiple disorders is also involved in the generation of toxic, neuron-killing protein fragments in Huntington's disease (HD). The research, published by Cell Press in the July 29 issue of Neuron, provides insight into Huntington's pathology and proposes new therapeutic strategies for this devastating incurable disease.

29 Jul 2010

Morphine blocks new blood vessel and tumor growth: Study

Current research suggests that taking morphine can block new blood vessel and tumor growth. The related report by Koodie et al, "Morphine suppresses tumor angiogenesis through a HIF1α/p38MAPK pathway," appears in the August 2010 issue of the American Journal of Pathology.

28 Jul 2010

New study reveals potential role of TGF-β1 in kidney disease

Fibrosis in the kidney is one of the key causes of progressive renal failure. High levels of the inflammatory molecule TGF-β1 in the kidney tubules due to tissue damage can cause fibrosis as well as nephron degeneration, resulting in loss of kidney function. To clarify the mechanisms regulating TGF-β1-mediated renal fibrosis, Koesters et al expressed high levels of TGF-β1 in renal tubules of mice. Nephron degeneration in this system was mediated by decomposition of the tubular cells. These data suggest that TGF-β1 may play a novel role in cell death of renal cells, thus contributing to renal fibrosis.

28 Jul 2010

Aperio receives patent for image viewing technology

Aperio Technologies, Inc., (Aperio), a global leader in digital pathology for the healthcare and life sciences industry, announced today that the United States Patent and Trademark Office has issued the company patent No. 7,738,688 entitled, "System and Method for Viewing Virtual Slides."

28 Jul 2010

BioImagene collaborates with ten new academic medical centers to develop digital pathology solutions

BioImagene, Inc., the leading provider of innovative digital pathology solutions has added ten new academic medical centers to its roster of collaborators during the last quarter. Many of these collaborators have been named "America's Best Hospitals 2010-2011: The Honor Roll" by U.S. News and World Report.

28 Jul 2010

ProTron Technologies creates Stethotron Intra-vascular Atherosclerotic Detector

Cardiovascular and cerebrovascular disease are the major causes of death in the world. Atherosclerotic plaque, the narrowing of blood vessels, causes audible turbulence in the bloodstream. Standard and electronic stethoscopes are designed to listen to heart and lung signals between 10-300 Hz. But as these waves do not travel in straight paths, and this frequency is a physiological sound, this uncertainty of origin may cause diagnosis errors.

27 Jul 2010

Cedars-Sinai Medical Center receives third consecutive full accreditation from AAHRPP

Cedars-Sinai Medical Center has received its third consecutive full accreditation from the Association for the Accreditation of Human Research Protection Programs, Inc., whose goal is to ensure that research institutions meet the highest standards in respecting and protecting individuals who participate in research.

27 Jul 2010

UCLA Health System launches hand transplantation program

The UCLA Health System has launched the new UCLA Hand Transplantation Program, the first of its kind on the West Coast and only the fourth such center in the United States. The program will help those who have suffered the traumatic loss of a hand or forearm and allow them to regain function and improve their quality of life. Qualified candidates are now being sought for a clinical study of the procedure.

27 Jul 2010

Pathology News and Research

Further Reading

Store-and-forward telemedicine as effective as in-person evaluation for planning ear surgery: Study

AMP conducts survey on Genetic Test Registry

Epigenetic changes to DNA in breast cancers linked with environmental risk factors, tumor size: Study

FDA lifts hold, allows Geron to proceed with Phase I clinical trial of GRNOPC1 in spinal cord injury

Despite all advancements in melanoma diagnosis, rapid treatment remains critical: Report

Researchers discover tumor suppressor lincRNAs

NeoGenomics second-quarter 2010 revenue increases 14% to $8.5 million

Safeguard Scientifics second-quarter aggregate revenue of partner companies increase 47% to $91.6 million

Clarient second-quarter net revenue increases 21% to $28.7 million

Scientists identify new targets to develop treatment for HD

NDS Surgical Imaging introduces ConnectOR G2 visualization and informatics platform

Loss of key nerve cells cause Parkinson's disease: Research

Inhibition of MMPs can offer therapeutic benefit in Huntington's disease: Study

Morphine blocks new blood vessel and tumor growth: Study

New study reveals potential role of TGF-β1 in kidney disease

Aperio receives patent for image viewing technology

BioImagene collaborates with ten new academic medical centers to develop digital pathology solutions

ProTron Technologies creates Stethotron Intra-vascular Atherosclerotic Detector

Cedars-Sinai Medical Center receives third consecutive full accreditation from AAHRPP

UCLA Health System launches hand transplantation program

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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