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JACC: Heart Failure from American College of Cardiology and Elsevier

Elsevier, a world-leading provider of scientific, technical and medical information products and services, and the American College of Cardiology (ACC) are pleased to announce that the American College of Cardiology (ACC) journals' portfolio has been expanded with the launch of JACC: Heart Failure.

5 Mar 2013

Gene cluster implicated in Behçet's disease

Scientists may have uncovered an underlying genetic susceptibility for Behçet's disease in East Asian patients.

5 Mar 2013

Regeneron, Sanofi announce pooled data from Phase 1b trials with dupilumab for atopic dermatitis

Sanofi and Regeneron Pharmaceuticals, Inc. announced that pooled data from two Phase 1b trials with dupilumab (REGN668/SAR231893), an investigational, high-affinity, subcutaneously administered, fully-human antibody targeting the alpha subunit of the interleukin 4 receptor (IL-4R alpha), were presented at the 71st Annual Meeting of the American Academy of Dermatology (AAD) in Miami.

4 Mar 2013

Faecal microbiota transplantation highly effective in treating recurrent C. difficile infections

Clostridium difficile infections have developed into a virtual pandemic over the past two decades. The outcome of standard antibiotic treatment is unsatisfactory: the recurrence rates are high with every relapse increasing the risk of further follow-ups. Faecal microbiota transplantation offers a rapidly acting and highly effective alternative in treating recurrent Clostridium difficile infections (RCDI), as Professor Lawrence J. Brandt (Montefiore Medical Center, New York, USA) points out.

27 Feb 2013

New journal aims to address fatigue in medical illnesses and specific environmental conditions

With peer-reviewed articles on fatigue having increased 90% over the past decade - and nearly 1,000 papers on the topic published in 2011 alone - the time is right for Routledge's new journal, Fatigue: Biomedicine, Health & Behavior.

27 Feb 2013

New confirmatory diagnostic test highly accurate in distinguishing mothers with preeclampsia

Carmenta Bioscience, Inc., in collaboration with researchers at Stanford University, today announced presentation of results from a retrospective clinical study at the 2013 Society of Maternal Fetal Medicine national meeting.

16 Feb 2013

Scopolamine may also be possible treatment for anxiety disorders

However, scopolamine is re-emerging as an antidepressant, with recent studies showing that scopolamine can rapidly improve mood in depressed patients. In addition, in a new study published in Biological Psychiatry this month by Dr. Moriel Zelikowsky and colleagues at the University of California, Los Angeles, it may also be a possible treatment for anxiety disorders.

13 Feb 2013

Menopausal brain changes support estrogen’s protective role in schizophrenia

Researchers have found morphological differences between pre- and postmenopausal women with schizophrenia that support a protective role for estrogen in the psychiatric disorder.

12 Feb 2013

Researchers identify an exceptional mouse model of schizophrenia

Researchers at the Institute for Comprehensive Medical Science, Fujita Health University and the National Institute for Physiological Sciences, Japan, along with colleagues from 9 other institutions, have identified an exceptional mouse model of schizophrenia.

7 Feb 2013

Migraine, epilepsy and genetics: an interview with Dr. Melodie Winawer

This work is the product of an extraordinary consortium called the Epilepsy Phenome/Genome project (EPGP). It is a consortium of 27 centres in the U.S. and internationally with several hundred physicians and staff who have worked together to enrol more than 4000 patients with epilepsy and their family members.

7 Feb 2013

Modafinil may help some people to reduce drinking by improving their impulse control

Poor impulse control contributes to one's inability to control the consumption of rewarding substances, like food, alcohol, and other drugs. This can lead to the development of addiction. FDA-approved medications for alcoholism, like naltrexone (Revia) and disulfiram (Antabuse), are thought to reduce alcohol consumption by curbing cravings and creating unpleasant reactions to alcohol, effects which reduce the desire to drink alcohol.

2 Feb 2013

Study supports hypothesis that disulfiram reduces drug consumption by blocking DβH

Disulfiram was the first medication approved for the treatment of alcoholism over 50 years ago. It works, at least in part, by preventing the metabolism of an alcohol by-product, acetaldehyde. High levels of acetaldehyde in the body quickly cause unpleasant symptoms, including nausea, vomiting, headache, and accelerated heart rate. Thus, disulfiram provides a very strong incentive to avoid drinking.

1 Feb 2013

Hyperconnectivity in brain emotion regions even in remitted bipolar I disorder

Bipolar I disorder patients who are in remission display increased coupling between brain regions involved in regulating emotions, even in the absence of a psychological task, shows a US study.

31 Jan 2013

Increasing age, male sex and adiposity risk factors for metabolic syndrome in children

Metabolic syndrome is more likely to affect children who are obese than overweight or non-overweight and who have other characteristics associated with the disorder, such as high blood pressure or insulin resistance. A new comprehensive and systematic review of the medical literature on metabolic syndrome in children that probed deeper to evaluate the risk associated with gender, ethnicity, and geography was published in Metabolic Syndrome and Related Disorders, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

31 Jan 2013

STS presents Earl Bakken Scientific Achievement Award to Stanford University professor

The Society of Thoracic Surgeons presented the Earl Bakken Scientific Achievement Award to D. Craig Miller, MD on Tuesday morning during the General Session at the STS 49th Annual Meeting.

31 Jan 2013

Dilaforette receives approval to initiate sevuparin Phase II malaria study in India

Dilaforette, a Karolinska Development portfolio company, today announces that the company has approval from the regulatory authority in India to start a Phase II study with sevuparin in patients with moderate to severe malaria.

30 Jan 2013

Carmenta acquires option to license Stanford technology for preeclampsia diagnostic test

Carmenta Bioscience, Inc., a privately held medical technology company focused on maternal and fetal health, today announced it has acquired the option for a worldwide, exclusive license from Stanford University to develop a set of tests enabling physicians to better diagnose and predict preeclampsia.

28 Jan 2013

Orbitofrontal cortex abnormality characteristic of deficit schizophrenia

The orbitofrontal cortex appears to play an important role in the development of severe negative symptoms in people with deficit schizophrenia, researchers suggest.

25 Jan 2013

Neuromuscular blockade (NMB) reversal

General anesthesia is made up of three components: hypnotic medicines, to induce sleep; analgesics, or medicines to inhibit pain; and NMB agents that induce muscle relaxation. Anesthesiology professionals use NMB to relax a patient’s muscles and prevent involuntary movement that could impact surgery.

24 Jan 2013

New targeted enzyme replacement therapy can treat X-linked myotubular myopathy

A collaborative research team including a Medical College of Wisconsin (MCW) pediatric neuropathologist successfully mitigated some of the effects of a muscular disease by using a new targeted enzyme replacement therapy strategy from 4s3 Bioscience.

23 Jan 2013

Pathophysiology News and Research

JACC: Heart Failure from American College of Cardiology and Elsevier

Gene cluster implicated in Behçet's disease

Regeneron, Sanofi announce pooled data from Phase 1b trials with dupilumab for atopic dermatitis

Faecal microbiota transplantation highly effective in treating recurrent C. difficile infections

New journal aims to address fatigue in medical illnesses and specific environmental conditions

New confirmatory diagnostic test highly accurate in distinguishing mothers with preeclampsia

Scopolamine may also be possible treatment for anxiety disorders

Menopausal brain changes support estrogen’s protective role in schizophrenia

Researchers identify an exceptional mouse model of schizophrenia

Migraine, epilepsy and genetics: an interview with Dr. Melodie Winawer

Modafinil may help some people to reduce drinking by improving their impulse control

Study supports hypothesis that disulfiram reduces drug consumption by blocking DβH

Hyperconnectivity in brain emotion regions even in remitted bipolar I disorder

Increasing age, male sex and adiposity risk factors for metabolic syndrome in children

STS presents Earl Bakken Scientific Achievement Award to Stanford University professor

Dilaforette receives approval to initiate sevuparin Phase II malaria study in India

Carmenta acquires option to license Stanford technology for preeclampsia diagnostic test

Orbitofrontal cortex abnormality characteristic of deficit schizophrenia

Neuromuscular blockade (NMB) reversal

New targeted enzyme replacement therapy can treat X-linked myotubular myopathy

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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