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Study uncovers a protein-protein interaction that contributes to Parkinson's disease

In a study published in Nature Communications, a team led by Krembil Brain Institute Senior Scientists, Drs. Lorraine Kalia and Suneil Kalia, and University of Toronto (U of T) Professor, Dr. Philip M. Kim, identified a protein-protein interaction that contributes to Parkinson's disease.

20 Apr 2023

The Power of Solid-State Nuclear Magnetic Resonance in Biological Research

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to this year's recipient of the Pittsburgh Spectroscopy Award, Robert Tycko.

From Pittcon 20 Apr 2023

Does the skin microbiome contribute to protection from prolonged solar damage?

Researchers examined how the skin microbiome contributes to protection from solar damage.

19 Apr 2023

Vaccine component BNT162b4 enhances T-cell immunity against SARS-CoV-2 variants for reduced COVID-19 disease severity

Researchers designed a novel messenger ribonucleic acid (mRNA) vaccine component designated BNT162b4.

17 Apr 2023

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Pieren, D. K. J., Kuguel, S. G., Rosado, J., Robles, A. G., Rey-Cano, J., Mancebo, C., Esperalba, J., Falcó, V., Buzón, M. J., & Genescà, M. (2023). Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-37559-w, https://www.nature.com/articles/s41467-023-37559-w

10 Apr 2023

Study illuminates how patients with variants in the PTPN2 gene develop IBD

Inflammatory bowel disease, or IBD, describes Crohn's disease and ulcerative colitis, two chronic diseases that cause inflammation in the intestines. IBD, which affects about 3 million adults in the United States, is an autoimmune disorder -; a condition in which the body's immune system attacks healthy tissues.

7 Apr 2023

Exploring the gut microbiome's role in rheumatoid arthritis pathogenesis

Researchers analyzed data on the association between intestinal microbiome dysbiosis and rheumatoid arthritis.

6 Apr 2023

Orbit Discovery and Evergreen Discovery collaborate to discover peptides for targeting radiopharmaceuticals

Evergreen Discovery (Evergreen), a leading radiopharmaceutical drug development company with a focus on the treatment and diagnosis of cancer.

From Orbit Discovery 3 Apr 2023

Lipid Nanoparticles (LNPs) and DNA delivery – unlocking the future of medical research

In this interview, Kate Stumpo speaks to Michael Girgis about Lipid nano particles, and the future of the field.

From Bruker Life Sciences Mass Spectrometry 31 Mar 2023

New insights and emerging disease-modifying drugs for Alzheimer’s disease treatment

A recent review published in Biochemical Pharmacology summarized the ongoing research, providing insights into pathophysiology and emerging drugs for Alzheimer’s disease (AD).

31 Mar 2023

Unlocking the potential of green seaweeds: Study explores nutrients, active substances

Researchers discuss the main nutrients and active substances associated with different green seaweeds, along with their biological activities and applications.

30 Mar 2023

Synthetic hydrogel-based lymphoma tumor model paves way for personalized cancer therapies

In recent years, innovative cancer drugs that target specific molecular drivers of the disease have been embraced as the treatment of choice for many types of cancer.

29 Mar 2023

Experimental anti-obesity drug may control appetite without surgery or nausea

Imagine getting the benefits of gastric bypass surgery without going under the knife -; a new class of compounds could do just that. In lab animals, these potential treatments reduce weight dramatically and lower blood glucose.

29 Mar 2023

Pneumolysin toxin holds promise for developing therapies against Streptococcus pneumoniae

In a recent study published in the journal PLoS ONE, researchers in Spain performed a systematic review of pneumolysin (PLY) toxin as a molecular target to develop novel therapeutics against Streptococcus pneumoniae.

27 Mar 2023

How can microbiota be used to make wine more health beneficial?

Researchers discussed the use of wine microbiota in enhancing the functional components of wine during production.

27 Mar 2023

Global search for sustainable protein sources: Turning to insects, weeds, and fungi to meet rising demand

Researchers explore novel foods such as unconventional legume crops, aquatic weeds, edible fungi, and insects as sources of proteins alternative to meat.

26 Mar 2023

Study outlines a meta-scale approach to quantifying the human proteome

A major puzzle of biology is that while the human genome contains roughly 20,000 genes, many comparatively primitive organisms -; including the universally-studied worm C. elegans -; have almost the same number of genes.

23 Mar 2023

SARS-CoV-2 infection damages CD8+ T cell response

In a recent study published in the journal Immunity, a team of researchers from the United States found that previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections reduce the activation and expansion of CD8+ T cells in response to coronavirus disease 2019 (COVID-19) vaccinations.

22 Mar 2023

SARS-CoV-2 infection enhances vaccine-induced immunological memory against spike protein

Researchers assess SARS-CoV-2 spike protein-specific immunological memory among unvaccinated and vaccinated convalescents.