Phenotype News and Research

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Health disparities in access to healthcare

Minority individuals are much more likely to develop and die from cancer than the general U.S. population.

16 Apr 2007

Weaker performance of siblings of children with autism spectrum disorder

Younger siblings of children with autism spectrum disorders do not perform as well on tests of social and communication development compared with siblings of children without developmental problems at ages as young as 12 months, according to a report in the April issue of Archives of Pediatrics & Adolescent Medicine, a theme issue on autism spectrum disorders.

4 Apr 2007

Researchers identify gene for osteoporosis

Researchers report the identification of a gene that may play a role in susceptibility to osteoporosis, the crippling disease that leads to bone fractures, especially of the hip and spine.

31 Mar 2007

Discovery of new cell involved with cancer

Scientists have discovered a new type of cell that appears to play a role in the development of cancer – a highly volatile, precancerous stem cell that can either remain benign or become malignant, depending upon environmental cues.

14 Mar 2007

Everyday plastics and pesticides may influence obesity

Obesity is generally discussed in terms of caloric intake (how much a person eats) and energy output (how much a person exercises).

18 Feb 2007

Selective marker found to indicate aggressive form of breast cancer

Researchers have linked a structural protein called nestin to a particularly deadly form of breast cancer, identifying a new biomarker that could lead to earlier detection and better treatment.

16 Jan 2007

New study emphasizes the importance of metabolomics to the advent of personalized medicine

International experts have collaborated on a comprehensive collection of reviews focusing on the emerging interface between metabolomics and pharmacogenomics.

24 Oct 2006

Bladder urothelium in PBS/IC shows distinct differences in keratin profiles

Research groups from the Netherlands and Denmark led by Pilar Laguna studied urothelial involvement in PBS/IC by characterizing the keratin phenotype of bladder urothelium in 18 patients with the disorder.

20 Aug 2006

Mice more complicated than humans when it comes to telomeres

In terms of their telomeres, mice are more complicated than humans. That's the finding from a recent Rockefeller University study.

2 Aug 2006

Genetic link to community makeup and ecosystem evolution

Genes of one organism not only control the characteristics of that individual but also dictate the behavior of thousands of other organisms in a community.

25 Jul 2006

The inability to recognize faces can be inherited

In the first study to examine whether the inability to recognize faces can be inherited, researchers found that it is in fact a common disorder that runs in families and is one of the most frequent disorders apparently controlled by a defect in a single gene.

9 Jul 2006

Pituitary adenoma predisposition caused by germline mutations in the AIP gene

A recent Finnish study identifies a low-penetrance gene defect which predisposes carriers to intracranial tumors called pituitary adenomas. In particular individuals carrying the gene defect are susceptible to such tumors which secrete growth hormone.

1 Jun 2006

Genetic variations impact sexual desire

New evidence that individual differences in human sexual desire can be attributed to genetic variations has been revealed by a research group headed by a professor of psychology at the Hebrew University of Jerusalem.

29 May 2006

Losartan can prevent progression of Marfan syndrome

A commonly prescribed blood pressure medication may provide the first ray of hope in preventing potentially deadly complications of Marfan syndrome, a genetic disease that weakens the structural meshwork of blood vessels.

11 Apr 2006

Genetic clues to longevity

In a new study, Drs. Gil Atzmon and Nir Barzilai at the Albert Einstein College of Medicine of Yeshiva University have found that people harbor alleles--alternative forms of a gene--that confer the same sort of longevity advantage.

4 Apr 2006

Duke University biologists evolve complex trait in the laboratory

Duke University biologists have evolved a complex trait in the laboratory -- using the pressure of selection to induce tobacco hornworms to evolve the dual trait of turning black or green depending on the temperature during their development.

12 Feb 2006

Aquaporin related to obesity

Dr. Gema Fruhbeck, director of the Metabolic Research Laboratory of the University Hospital of the University of Navarra, has published a commentary in the latest issue of Nature. The article presents aquaporin as a new modulator of the biology of the adipocyte.

21 Dec 2005

HRAS mutation analysis in Costello Syndrome

Gene mutations in the HRAS sequence are present in most patients affected with Costello syndrome, according to a new study in the American Journal of Medical Genetics. The mutations occurred de novo in patients, meaning, they were not observed in their parents' genes.

5 Dec 2005

Study links low level of response (LR) to alcohol to an area on chromosome 10

How a person "feels" the effects of alcohol is, in part, genetically influenced and relates to their risk for developing alcoholism.

28 Nov 2005

Study finds AKT blocks cancer cell motility

PIn investigating the molecular mechanisms of cancer cell motility - the unique property that enables cancer to spread from its primary origin to other parts of the body - researchers have uncovered a surprising role for the AKT/PKB (protein kinase B) enzyme

26 Nov 2005