Phenotype News and Research

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2-bromopalmitate reduces senescence phenotype in human cells by modulating palmitoylation

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 16 on August 23, 2024, entitled, "2-Bromopalmitate treatment attenuates senescence phenotype in human adult cells - possible role of palmitoylation."

11 Sep 2024

New molecular map offers insights into human physiology and disease

Scientists at Weill Cornell Medicine in Qatar (WCM-Q) have created an intricate molecular map of the human body and its complex physiological processes based on the analysis of thousands of molecules measured in blood, urine and saliva samples from 391 volunteers.

11 Sep 2024

PDX engraftment predicts high recurrence and poor survival in triple-negative breast cancer

Researchers examine the association between patient-derived xenograft with recurrence and survival rates in triple negative breast cancer patients.

11 Sep 2024

Addressing the challenges of polycystic kidney disease

Polycystic kidney disease (PKD) is an intractable disorder that causes fluid-filled cysts to grow in the kidneys. It is typically seen in adults. As one of the most prevalent hereditary kidney diseases, the autosomal dominant form of PKD is usually caused by mutations in the PKD1 and PKD2 genes.

11 Sep 2024

New target identified for potential ALS therapy

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects motor neurons.

10 Sep 2024

Study reveals how sex hormones regulate immune system functions

Findings indicate that testosterone therapy in trans men alters immune system responses, suggesting implications for disease susceptibility and treatment.

6 Sep 2024

Early cholesterol spikes fuel atherosclerosis by altering macrophages

Early intermittent hyperlipidemia significantly accelerates atherosclerosis by disrupting macrophage function, highlighting the need for early cholesterol management.

6 Sep 2024

Study reveals geographic variations in cardiovascular risk for Chinese American immigrants

A new UCLA-led study found that cardiovascular disease risk among Chinese American immigrants increases with length of residence and varies by location in the U.S. The study, which leveraged data from the MESA (Multi-Ethnic Study of Atherosclerosis) cohort, sponsored by the National Heart, Lung, and Blood Institute (NHLBI), observed the heart health of 746 Chinese Americans in both Los Angeles and Chicago over a period of roughly 18 years.

5 Sep 2024

Intranasal vaccine shows broad SARS-CoV-2 variant protection

Study demonstrates that a single-dose intranasal live-attenuated vaccine, CDO-7N-1, provides broad protection against SARS-CoV-2 and its variants by inducing potent immune responses, including neutralizing antibodies and T-cell activity, in animal models.

1 Sep 2024

T-TEER shows promising outcomes in severe tricuspid regurgitation patients after one year

Tricuspid transcatheter edge-to-edge repair (T-TEER) significantly reduced the severity of secondary tricuspid regurgitation and improved quality of life after 1 year, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

Hereditary cardiac amyloidosis more common in the UK than previously thought

More people in the UK are at risk of a hereditary form of cardiac amyloidosis, a potentially fatal heart condition, than previously thought, according to a new study led by researchers at UCL (University College London) and Queen Mary University of London.

28 Aug 2024

Scientists discover how a gut insulin antagonist controls fat loss in C. elegans by modulating brain signals

Researchers have identified an endogenous insulin antagonist, INS-7, in Caenorhabditis elegans that modulates fat loss by inhibiting a gut-to-brain signaling pathway involving the neuropeptide FLP-7.

27 Aug 2024

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

The study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and plaque formation in arteries.

27 Aug 2024

The significance of CHEK2 variants in cancer risk assessment

A new editorial was published in Oncotarget's Volume 15 on July 10, 2024, entitled, "Genotype matters: Personalized screening recommendations for germline CHEK2 variants."

27 Aug 2024

GluFormer outperforms existing AI models in predicting blood sugar levels

Study introduces GluFormer, a transformer-based generative model, to predict glycemic patterns using continuous glucose monitoring data, with significant implications for diabetes management and treatment strategies.

26 Aug 2024

Study sheds light on the dual nature of cellular senescence

Scientists at Sanford Burnham Prebys and the La Jolla Institute for Immunology have revealed a new secret regarding senescence, a cellular state similar to sleep that is more likely to affect aged cells.

22 Aug 2024

New tool could revolutionize cardiovascular risk management: PRESS score validated

The association between platelet hyperreactivity and the risk of cardiovascular events.

22 Aug 2024

$Gut microbiota linked to fracture risk: Study reveals key microbial associations$

Gut microbiota linked to fracture risk: Study reveals key microbial associations

The association between gut microbiota (GM) composition and incident fractures in the Finnish Risk Monitoring Program (FINRISK) 2002 cohort.

19 Aug 2024

New insights into lipid-induced senescence in dopaminergic neurons

A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 19, 2024, entitled, "Lipid accumulation drives cellular senescence in dopaminergic neurons."

13 Aug 2024

Researchers identify key genetic players in dopamine signaling using transparent worms With The Help Of A Tin...

Dopamine, a powerful brain chemical and neurotransmitter, is a key regulator of many important functions such as attention, experiencing pleasure and reward, and coordinating movement.

12 Aug 2024

Phenotype News and Research

2-bromopalmitate reduces senescence phenotype in human cells by modulating palmitoylation

New molecular map offers insights into human physiology and disease

PDX engraftment predicts high recurrence and poor survival in triple-negative breast cancer

Addressing the challenges of polycystic kidney disease

New target identified for potential ALS therapy

Study reveals how sex hormones regulate immune system functions

Early cholesterol spikes fuel atherosclerosis by altering macrophages

Study reveals geographic variations in cardiovascular risk for Chinese American immigrants

Intranasal vaccine shows broad SARS-CoV-2 variant protection

T-TEER shows promising outcomes in severe tricuspid regurgitation patients after one year

Hereditary cardiac amyloidosis more common in the UK than previously thought

Scientists discover how a gut insulin antagonist controls fat loss in C. elegans by modulating brain signals

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

The significance of CHEK2 variants in cancer risk assessment

GluFormer outperforms existing AI models in predicting blood sugar levels

Study sheds light on the dual nature of cellular senescence

New tool could revolutionize cardiovascular risk management: PRESS score validated

Gut microbiota linked to fracture risk: Study reveals key microbial associations

New insights into lipid-induced senescence in dopaminergic neurons

Researchers identify key genetic players in dopamine signaling using transparent worms With The Help Of A Tin...

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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