Phenotype News and Research

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Using ex vivo gene therapy to fight obesity and diabetes in mice

A scientific team from the University of Barcelona and the CIBERobn has designed a strategy to fight obesity and diabetes in mice through ex vivo gene therapy which consists of implanting cells that have been manipulated and transformed in order to treat a disease.

30 May 2023

Mental health profoundly impacts inflammatory responses in the body

Study uncovered mechanisms by which psychological stress affects bowel inflammation.

30 May 2023

Passing on Polycystic Ovary Syndrome: Health risks for Male offspring of Women with PCOS

In this interview, we spoke to two researchers from the Karolinska Institutet about their latest work that investigated how PCOS can affect the health of future generations of men.

29 May 2023

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to this year's recipient of the Pittsburgh Analytical Chemistry Award, Neil Kelleher, about his work in top-down proteinomics.

From Pittcon 26 May 2023

First-in-human nanoparticle HIV vaccine induces broad and publicly targeted helper T cell responses

Researchers from Fred Hutchinson Cancer Center in Seattle, Scripps Research in La Jolla, California, IAVI and other collaborating institutions have characterized robust T-cell responses in volunteers participating in the IAVI G001 Phase 1 clinical trial to test the safety and immune response of a self-assembling nanoparticle HIV vaccine.

25 May 2023

Exercise capacity found to be lower than expected among people with long COVID

While some patients recover from the effects of SARS-CoV-2 infection, others have experienced the aftereffects of COVID-19 long after the initial infection. One of these long COVID symptoms is reduced exercise capacity.

25 May 2023

Higher intake of flavonol-rich foods linked to lower odds of developing frailty

Eating plant-based foods that contain dietary compounds called flavonols can lower your chances of developing frailty.

23 May 2023

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Writing in the May 22, 2023 issue of Cell Systems, a diverse team of scientists, led by researchers at University of California San Diego School of Medicine, have produced a novel map that depicts the human body's enormously complicated and highly evolved system for addressing and repairing DNA damage -; a cause and consequence of many diseases.

22 May 2023

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

Unraveling how the interplay between Sargassum, plastic marine debris and Vibrio bacteria creates the perfect "pathogen" storm

A new study uncovers how the interplay between Sargassum spp., plastic marine debris and Vibrio bacteria creates the perfect "pathogen" storm that has implications for both marine life and public health. Vibrio bacteria are found in waters around the world and are the dominant cause of death in humans from the marine environment.

18 May 2023

Does obstructive sleep apnea increase the risk of post-acute sequelae of SARS-CoV-2?

Research paper examines the potential link between obstructive sleep apnea (OSA) and Post-Acute Sequelae of SARS-CoV-2 (PASC), the long-term effects of COVID-19. It investigates whether OSA increases the risk of more severe PASC outcomes.

15 May 2023

Metabolically healthy and unhealthy 'forms' of obesity linked with increased risk of obesity-related cancers

New research to be presented at this coming week's European Congress on Obesity in Dublin, Ireland (17-20 May) and published in the Journal of the National Cancer Institute shows that both the metabolically healthy and unhealthy 'forms' of obesity are associated with an increased risk of various obesity-related cancers, with the relationship stronger in metabolically unhealthy obesity.

15 May 2023

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Researchers conducted a phase I clinical trial of a personalized mRNA neoantigen vaccine.

12 May 2023

Pioneering AI-based approach identifies rare disease patients using electronic health records

Research paper describes the use of Symptoma's AI-based approach to identify patients with Pompe disease from retrospective electronic health records. The study found a prevalence of one in every 18,427 people for Pompe disease in the greater Salzburg region and established phenotypes for patient cohorts with an onset of symptoms above or below 1 year of age.

11 May 2023

AI algorithms for rare disease diagnosis ignore the genetic, morphological diversity of humans

Up to 40% of rare diseases show facial alterations that enable researchers to identify some pathologies and they can even help them to establish an early diagnosis.

10 May 2023

Neanderthal genes shape human noses

Research reports a study on the genetics of facial features in Latin Americans using automatic landmarking of 2D portraits and genome-wide association analysis. The study identified novel regions associated with facial features, including a region in 1q32.3 that shows introgression from Neanderthals and influences nasal height.

10 May 2023

Baylor scientists link MRTFB gene variants with novel neurodevelopmental disorder

Researchers at Baylor College of Medicine have linked specific variants or mutations of the gene myocardin-related transcription factor B (MRTFB) with a novel neurodevelopmental disorder.

9 May 2023

Combination treatment shows promise for aggressive subtype of non-Hodgkin lymphoma

Nearly 90 percent of patients with an aggressive subtype of non-Hodgkin lymphoma had their cancer go into remission in a small phase 2 clinical trial testing a treatment aimed at making chemotherapy more effective, according to Weill Cornell Medicine and NewYork-Presbyterian investigators.

5 May 2023

IL-6 regulation in colon cancer-associated fibroblasts through vitamin A metabolism

A new research perspective was published in Oncotarget's Volume 14 on April 26, 2023, entitled, "Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism."

4 May 2023

The African Personalized Medicine Agenda

In this interview, Rizwana Mia, the Senior Program Manager at South African Medical Research Council, talks to News Medical about the African personalized medicine agenda.

From MGI 4 May 2023

Phenotype News and Research

Using ex vivo gene therapy to fight obesity and diabetes in mice

Mental health profoundly impacts inflammatory responses in the body

Passing on Polycystic Ovary Syndrome: Health risks for Male offspring of Women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

First-in-human nanoparticle HIV vaccine induces broad and publicly targeted helper T cell responses

Exercise capacity found to be lower than expected among people with long COVID

Higher intake of flavonol-rich foods linked to lower odds of developing frailty

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Unraveling how the interplay between Sargassum, plastic marine debris and Vibrio bacteria creates the perfect "pathogen" storm

Does obstructive sleep apnea increase the risk of post-acute sequelae of SARS-CoV-2?

Metabolically healthy and unhealthy 'forms' of obesity linked with increased risk of obesity-related cancers

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Pioneering AI-based approach identifies rare disease patients using electronic health records

AI algorithms for rare disease diagnosis ignore the genetic, morphological diversity of humans

Neanderthal genes shape human noses

Baylor scientists link MRTFB gene variants with novel neurodevelopmental disorder

Combination treatment shows promise for aggressive subtype of non-Hodgkin lymphoma

IL-6 regulation in colon cancer-associated fibroblasts through vitamin A metabolism

The African Personalized Medicine Agenda

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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