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Boosting ketone levels enhances heart function in mice with HFpEF, study shows

Increasing ketone supply to the heart in mice with heart failure with preserved ejection fraction (HFpEF) allowed their hearts to utilize more ketones and produce more energy, according to preliminary research presented today at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2024.

24 Jul 2024

Kaempferol's promise in fighting triple-negative breast cancer

Review highlights kaempferol's potential in treating triple-negative breast cancer through various anticancer mechanisms and improving chemotherapeutic efficacy.

24 Jul 2024

Dietary interventions improve mitochondrial function and reduce inflammation in obesity

Study demonstrates that dietary interventions such as calorie restriction, intermittent fasting, and ketogenic diet improve mitochondrial function in monocytes and reduce inflammation in obesity by modulating gut microbiota.

23 Jul 2024

Innovative genetic approaches to rare disease diagnosis

The majority of rare diseases have a genetic cause. The underlying genetic alteration can be found more and more easily, for example by means of exome sequencing (ES), leading to a molecular genetic diagnosis.

22 Jul 2024

DDX41: A unique player in myeloid leukemogenesis

A new editorial paper was published in Oncotarget's Volume 15 on July 2, 2024, entitled, "DDX41 and its unique contribution to myeloid leukemogenesis."

19 Jul 2024

Discovery of over 1,000 undetected proteins in metabolite samples

Van Andel Institute scientists have identified more than 1,000 previously undetected proteins in common metabolite samples, which persist despite extraction methods designed to weed them out.

18 Jul 2024

Drinking coffee daily linked to decreased PCOS risk

A recent study reveals that daily coffee consumption significantly reduces the risk of developing PCOS symptoms. Women who drank two cups of coffee daily were at a 70% lower risk of PCOS.

17 Jul 2024

E. coli genomic analysis uncovers antibiotic resistance mechanisms in dogs

Researchers studying antimicrobial-resistant E. coli – the leading cause of human death due to antimicrobial resistance worldwide – have identified a mechanism in dogs that may render multiple antibiotic classes ineffective.

16 Jul 2024

Discovery of "unconventional" immune response opens new avenue in TB vaccine development

An "unconventional" immune response now identified by scientists from the Hackensack Meridian Center for Discovery and Innovation (CDI) is a potential new pathway for developing new vaccines for tuberculosis (TB), according to a new publication.

15 Jul 2024

New 3D model sheds light on amyloid-beta's impact

Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have unveiled a pioneering study shedding light on the intricate mechanisms underlying Alzheimer's disease (AD). The study, titled "Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype," represents a significant leap forward in understanding the interplay between amyloid-like structures and neuronal cells.

13 Jul 2024

Unveiling late-onset combined immunodeficiency in patients with 18q del syndrome

Chromosome 18q deletion (18q del) syndromeis a rare genetic condition disorder, affecting approximately 1 in 40,000 to 55,000 individuals, caused by the deletion of genetic material on the long arm of chromosome 18.

11 Jul 2024

Archaeal, fungal, viral, as well as bacterial, functional makers for autism spectrum disorder in children

Researchers investigated the associations between multikingdom gut microbiome components and functional markers with autism spectrum disorder through metagenomic sequencing of children's fecal samples.

11 Jul 2024

More than 1,000 small changes in DNA identified that influence age of first period

Researchers examined nearly 800,000 women's DNA to explore puberty timing complexities. They identified signals related to menarche timing and investigated their influence on puberty onset.

4 Jul 2024

Impaired communication between immune cells leads to cognitive impairment in female Alzheimer's patients

Lead author Neta Rosenzweig, PhD, of the Ann Romney Center for Neurological Diseases, and senior author Oleg Butovsky, PhD, of the Ann Romney Center and Gene Lay Institute of Immunology and Inflammation, share key messages from their paper "Sex-Dependent APOE4 Neutrophil-Microglia Interactions Drive Cognitive Impairment in Alzheimer's Disease" published in Nature Medicine.

3 Jul 2024

Gene mutation explains heart defects in children

A new groundbreaking study sheds light on a medical question scientists have long wondered: why do 40 per cent of children with the rare neurodevelopmental disorder KBG syndrome have heart defects? The research now points to a critical link between the heart and the brain.

3 Jul 2024

Phenotype News and Research

Boosting ketone levels enhances heart function in mice with HFpEF, study shows

Kaempferol's promise in fighting triple-negative breast cancer

Dietary interventions improve mitochondrial function and reduce inflammation in obesity

Innovative genetic approaches to rare disease diagnosis

DDX41: A unique player in myeloid leukemogenesis

Discovery of over 1,000 undetected proteins in metabolite samples

Drinking coffee daily linked to decreased PCOS risk

E. coli genomic analysis uncovers antibiotic resistance mechanisms in dogs

Discovery of "unconventional" immune response opens new avenue in TB vaccine development

New 3D model sheds light on amyloid-beta's impact

Unveiling late-onset combined immunodeficiency in patients with 18q del syndrome

Archaeal, fungal, viral, as well as bacterial, functional makers for autism spectrum disorder in children

More than 1,000 small changes in DNA identified that influence age of first period

Impaired communication between immune cells leads to cognitive impairment in female Alzheimer's patients

Gene mutation explains heart defects in children

Unveiling the epigenetic transformation in insulinomas: Insights into beta cell neoplasia

Researchers identify key osteoporosis-related gene and develop new mouse model of the disease

Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue

Sleep patterns reveal hidden health clues

Wearable devices show how sleep patterns change with health conditions

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

Understanding Consumer-Consented Data to Optimize Digital Health Programs

The Future is Wearable: Advancing Human Health Through Portable Spectroscopy

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