Phenotype News and Research

RSS

Mutated gene linked to 3-year-old girl's severe neurological symptoms

A young girl with severe neurological symptoms finally has a diagnosis, following the discovery by the Translational Genomics Research Institute of a genetic mutation that likely caused the girl to experience a cascade of symptoms.

24 Jul 2018

Restoring mitochondrial function to reverse aging-related skin wrinkles, hair loss in mice

Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed?

20 Jul 2018

Researchers uncover cause for progression of prostate cancer to incurable stage

Researchers at the University of Oulu in Finland have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism rs11672691 influences prostate cancer aggressiveness.

20 Jul 2018

Researchers develop first comprehensive atlas of lung tumor cells

Researchers from VIB, Leuven University and University Hospital Leuven studied thousands of healthy and cancerous lung cells to create the first comprehensive atlas of lung tumor cells.

10 Jul 2018

Researchers identify genes associated with aggressive behavior

Researchers from the University of Barcelona and collaborators have pin-pointed forty genes that are associated with aggressive behaviors in humans and in mice.

9 Jul 2018

Natural selection may have influence on personalities, suggests study

For more than a century, scientists have understood that natural selection have profound effects on how an animal looks - Anolis lizards that spend more time on the ground, for example, might need longer legs for running, while species that remain in the trees usually have shorter legs better suited for climbing.

4 Jul 2018

Scientists win NIH grant to study discrete subaortic stenosis

Scientists at Rice University, Texas Children's Hospital and Baylor College of Medicine have won a prestigious National Institutes of Health grant to study the dynamic processes and cellular players linked to discrete subaortic stenosis, a congenital heart disease.

27 Jun 2018

Salk Institute scientists receive funding for cancer research

Salk Institute scientists Ronald Evans, Diana Hargreaves, Tony Hunter, Graham McVicker and Geoffrey Wahl are among the first wave of researchers to receive funding from Padres Pedal the Cause, one of one of the largest stand-alone cancer fundraising events in San Diego.

27 Jun 2018

Microbiotica partners with University of Adelaide to develop defined bacterial product for ulcerative colitis

Microbiotica, a leading player in microbiome-based therapeutics, today announced that it has entered into an agreement with University of Adelaide as part of its program to develop a defined bacterial product for ulcerative colitis (UC). Financial details have not been disclosed.

19 Jun 2018

Study: Effects of in vitro fertilization depend on genetic variation inherited from parents

In vitro fertilization affects the regulatory region of genes essential for placental and embryonic growth, as well as the birth weight.

19 Jun 2018

Study: Immunization with beneficial bacteria can have long-lasting anti-inflammatory effects on the brain

Immunization with beneficial bacteria can have long-lasting anti-inflammatory effects on the brain, making it more resilient to the physical and behavioral effects of stress, according to new research by University of Colorado Boulder scientists.

7 Jun 2018

Microbiotica collaborates with Genentech to develop drugs for IBD

Microbiotica, a leading player in microbiome-based therapeutics spun out of the Wellcome Sanger Institute, today announced that it has entered into a multi-year strategic collaboration with Genentech, a member of the Roche Group, to discover, develop and commercialize biomarkers, targets and medicines for inflammatory bowel disease.

6 Jun 2018

Mapping the Genes Responsible for Pluripotency

Dr. Atilgan Yilmaz and his team have developed a method by which they can produce haploid human embryonic stem cells from oocytes. They combined this technique with CRISPR-Cas9 to generate an atlas of the genome, containing the functions of over 18,000 genes.

23 May 2018

Cleveland Clinic researcher wins NCI grant to delve into cancer genetics and radiation effectiveness

Can the genetic makeup of their cancers predict how patients with lung cancer will respond to radiation therapy? And can this information be used to advance a genetically guided strategy for patients with these tumors? Cleveland Clinic researcher and radiation oncologist Mohamed Abazeed, M.D., Ph.D., has been awarded a $2 million grant from the National Cancer Institute (NCI) to delve into those and other related questions.

15 May 2018

Disruption of the body's circadian rhythm linked to increased risk of breast cancer

For years, doctors have associated the BRCA1 and BRCA2 gene mutations with an increased risk of breast cancer.

9 May 2018

Detailed genetic testing of head and neck cancers could lead to more personalized treatments

Research led by UNC School of Medicine student Wesley Stepp, PhD, shows how more detailed genetic testing of head and neck tumors could lead to more personalized treatments for patients.

26 Apr 2018

Scientists develop tissue-engineered models to better understand cancer metastases

Cancer that has spread, or metastasized, from its original site to other tissues and organs in the body is a leading cause of cancer death.

24 Apr 2018

Research team identifies new mutation behind heart failure in South Asians

An international research team involving Karolinska Institutet has identified a new mutation in South Asians that, in combination with a known mutation in the same gene, increases the risk of cardiomyopathy and heart failure.

12 Apr 2018

Biomarker panel can guide future therapeutic decisions for glioma patients

In an article published April 10th in the journal Cell Reports, researchers at the University of São Paulo describe a biomarker panel that could tell physicians which patients diagnosed with glioma, a type of brain cancer, will tend to progress to a more aggressive form of the disease in the event of relapse.

10 Apr 2018

Newly discovered predictive biomarkers could help assess level of glioma recurrence risk

Researchers have identified specific predictive biomarkers that could help assess the level of risk for recurrence in patients with malignant glioma. The study, led by Henry Ford Health System's Department of Neurosurgery and Department of Public Health Sciences, was published today in Cell Reports.