Phenotype News and Research

RSS

Removal of single mitochondrial protein leads to severe inflammation

The link between mitochondria and inflammation is still unclear. But it is known is that, for example, the accumulation of defective mitochondria, which should have been removed, causes inflammation.

10 Apr 2018

Cardiac fibroblasts contribute to heart disease

An article published in Experimental Biology and Medicine reports that supporting cells in the heart, known as fibroblasts, are selectively activated by factors present in heart disease.

9 Apr 2018

Researchers find unexpected anti-inflammatory effects in PCSK9 inhibitors

PCSK9 inhibition is a new therapeutic strategy for atherosclerosis which is known to lower LDL cholesterol.

5 Apr 2018

TPP-related compounds selectively shut down cancer cells with little or no effect on healthy cells

SCIENTISTS seeking to make chemotherapies which are less harmful to cancer patients have reported "highly promising" results from a synthetic molecule called TPP.

21 Mar 2018

Researchers find way to identify undiagnosed genetic diseases in electronic health records

Patients diagnosed with heart failure, stroke, infertility and kidney failure could actually be suffering from rare and undiagnosed genetic diseases.

16 Mar 2018

Researchers find link between increased proteostasis and immortality of stem cells

Stem cells are considered to be immortal in culture and, therefore, of great interest for aging research. This immortality is regulated by increased proteostasis, which controls the quality of proteins.

8 Mar 2018

UCalgary researchers provide new understanding of relationship between gene mutations

The more information you have, the better able you are to predict what will happen next. Clinicians and health researchers often look at gene mutation to predict whether a fetus is at risk for a birth defect, or a person is at risk of developing a disease, but these predictions are not always accurate.

7 Mar 2018

TSRI scientists discover new target for treating major depressive disorder

Scientists on the Florida campus of The Scripps Research Institute have discovered a new target for treating major depressive disorder, a disease that affects more than 16 million American adults.

1 Mar 2018

Researchers describe important step toward gene therapy for patients with Sandhoff disease

Babies with the rare, deadly genetic disorder Sandhoff disease begin to miss developmental milestones just months after birth. Lacking muscle tone, they never learn to sit up, develop heads too large to lift and eventually suffer uncontrollable seizures. There is no cure.

22 Feb 2018

Moderate and severe exacerbations associated with decline in physical activity of COPD patients

A study led by researchers from the Barcelona Institute for Global Health, a center supported by the "la Caixa" Banking Foundation, has shown that both moderate and severe exacerbations in COPD patients are associated with a decline in their physical activity level.

20 Feb 2018

Using CRISPR To Produce Induced Pluripotent Stem Cells

An interview with Dr. Sheng Ding about using a modified version of the CRISPR-Cas9 system to produce induced pluripotent stem cells.

9 Feb 2018

Study finds new stem cell pathway that allows triple-negative breast cancer to thrive

Cleveland Clinic researchers have published findings in Nature Communications on a new stem cell pathway that allows a highly aggressive form of breast cancer - triple-negative breast cancer - to thrive.

8 Feb 2018

Study unravels developmental splicing program that promotes neuronal maturation

Neurons, or nerve cells, in the brain communicate with each other by transmitting electric signals, or firing action potentials, through long processes named axons (which send out signals) and dendrites (which receive signals).

1 Feb 2018

SUTD-NCL team completes phenotypic screening of MMV Malaria Box against pathogenic parasites

A Singapore-India collaborative research project between the Singapore University of Technology & Design and CSIR-National Chemical Laboratories completed phenotypic screening of a large collection of potent chemical inhibitors (known as MMV Malaria Box), against pathogenic parasites Toxoplasma gondii and Plasmodium falciparum, causative agents of human toxoplasmosis and malaria.

27 Jan 2018

Valproic acid exposure results in characteristics linked to autism, zebrafish study shows

Exposure to a compound used to treat migraines and seizures causes characteristics associated with autism, groundbreaking research with zebrafish has demonstrated.

24 Jan 2018

Scientists elucidate surprising dual function of ceramide synthase

Scientists at the University of Bonn have clarified a surprising dual function of ceramide synthase. The enzyme not only catalyzes a central step of the production of vital lipids. It also has the ability to turn genes involved in lipid metabolism on or off. The study is being published in the renowned journal Cell Reports.

24 Jan 2018

New genomic tools provide better understanding of the human immune system

When the body is under attack from pathogens, the immune system marshals a diverse collection of immune cells to work together in a tightly orchestrated process and defend the host against the intruders.

22 Jan 2018

Researchers propose new regulation mechanism linked to action of SirT6 on chromatin

Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute, led by Dr. Àlex Vaquero, have proposed a new regulation mechanism of the NF-κB pathway, which is associated with accelerated cellular aging, based on the analysis of the function of the SirT6 protein.

19 Jan 2018

Prostate cancer’s gene-determined ‘immune landscape’ dictates tumor progression

The field of immunotherapy - the harnessing of patients' own immune systems to fend off cancer - is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.

12 Jan 2018

Why Should We Weigh Every Protein in the Human Body?

Our mission is to advance the measurement of human proteins with greater precision, to bring to the world the benefits of absolute molecular specificity when it comes to interrogating proteins at the molecular level.

From Pittcon 5 Jan 2018