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New clues to how stem cells form

An Emory University study shows some of the first direct evidence of a process required for epigenetic reprogramming between generations – a finding that could shed more light on the mechanisms of fertilization, stem-cell formation and cloning.

16 Apr 2009

The DECIPHER database - revolutionising clinical practice and genetic research

Today - five years after the inception of the DECIPHER database - researchers have published a report that reveals the developing role of the database in revolutionising both clinical practice and genetic research.

15 Apr 2009

Missing link between fructose, insulin resistance found

A new study in mice sheds light on the insulin resistance that can come from diets loaded with high-fructose corn syrup, a sweetener found in most sodas and many other processed foods.

2 Apr 2009

New project to develop blood tests for heart disease and stroke

The landmark Framingham Heart Study (FHS) is launching a major initiative to discover risk factors and markers that could lead to new blood tests to identify individuals at high risk of heart disease and stroke.

12 Mar 2009

Brain tumor treatment may increase number of cancer stem-like cells

A new study suggests that the standard treatment for a common brain tumor increases the aggressiveness of surviving cancer cells, possibly leaving patients more vulnerable to tumor recurrence.

5 Mar 2009

Missing link between fructose, insulin resistance found

A new study in mice sheds light on the insulin resistance that can come from diets loaded with high-fructose corn syrup, a sweetener found in most sodas and many other processed foods.

3 Mar 2009

Ethnic differences found for fatty liver disease and insulin resistance

A new study suggests that the metabolic response to obesity and insulin resistance, particularly as it pertains to the liver, differs among ethnic groups in the U.S. African-Americans are more resistant to the buildup of fat in the abdominal adipose tissue and liver, and to high triglyceride levels associated with insulin resistance.

25 Feb 2009

VAP cholesterol test helps find link between a rare gene mutation and heart protection

Using the VAP Cholesterol Test from Atherotech, Inc., University of Maryland researchers have found an association between a rare gene mutation and heart protection.

17 Feb 2009

New test predicts how breast cancer patients respond to chemotherapy

Researchers at the Swiss Institute of Bioinformatics and the Swiss National Center of Competence in Research in Molecular Oncology in Lausanne have developed a new test to predict how breast cancer patients respond to chemotherapy, which could help change how treatment is delivered in the future.

3 Feb 2009

Fibroblasts invade at a snail's pace

A transcription factor known to drive the formation of fibroblasts during development also promotes their ability to invade and remodel surrounding tissues, report Rowe et al. in the February 9, 2009 issue of the Journal of Cell Biology.

2 Feb 2009

Opposite approach to asthma treatment may be in order

Just when the Food and Drug Administration is reconsidering the use of stimulants to treat asthma, a new research study offers further evidence to support a University of Houston professor's theory that an opposite approach to asthma treatment may be in order.

27 Jan 2009

Genetic interactions are the key to understanding complex traits

In recent years, genetic studies have uncovered hundreds of DNA variations linked to common diseases, such as cancer or diabetes, raising the prospect that scientists can gauge disease risk based on information in an individual's genome.

23 Jan 2009

Nitric oxide monitoring does not help most children with asthma

The level of nitric oxide (NO) in an asthmatic's exhaled breath can portend worsening asthma symptoms, and may even signify an imminent attack linked to underlying airway inflammation.

7 Jan 2009

Cylene Pharmaceuticals starts CX-4945 trial - first-in class inhibitor of CK2

Cylene Pharmaceuticals announced today that it has initiated a Phase I clinical trial of its oral CK2 protein kinase inhibitor, CX-4945, in patients with advanced solid tumors, Castleman's disease, or multiple myeloma.

5 Jan 2009

Breakthrough on type 1 diabetes development

Finnish scientists have reported a breakthrough in the attempts to understand the development of type 1 diabetes.

17 Dec 2008

Discovery of gene mutation that appears to help prevent heart disease

Researchers at the University of Maryland School of Medicine in Baltimore have discovered a novel gene mutation among the Old Order Amish population that significantly reduces the level of triglycerides in the blood and appears to help prevent cardiovascular disease.

12 Dec 2008

Genetic markers identified for alcohol response

Researchers at the UCSF Ernest Gallo Clinic and Research Center have identified a region on the human genome that appears to determine how strongly drinkers feel the effects of alcohol and thus how prone they are to alcohol abuse.

10 Dec 2008

Overweight children may inherit faster eating behaviour

Overweight children may inherit faster eating behaviour according to a Cancer Research UK study published in the American Journal of Clinical Nutrition.

10 Dec 2008

Incyte's selective Janus kinase inhibitor demonstrates rapid and durable clinical benefits in Myelofibrosis patients

Incyte Corporation will present updated results from an ongoing Phase II trial of INCB18424, its selective, orally available Janus kinase (JAK) inhibitor, in patients with myelofibrosis (MF) at the 50th American Society of Hematology (ASH) Annual Meeting.

8 Dec 2008

Anti-oestrogen drugs may promote more harmful cancer cell behaviour

The authors found that tamoxifen can promote an invasive phenotype in ER+ breast cancer cells under conditions of poor cell-cell contact, a previously unknown effect of this drug

3 Dec 2008

Phenotype News and Research

New clues to how stem cells form

The DECIPHER database - revolutionising clinical practice and genetic research

Missing link between fructose, insulin resistance found

New project to develop blood tests for heart disease and stroke

Brain tumor treatment may increase number of cancer stem-like cells

Missing link between fructose, insulin resistance found

Ethnic differences found for fatty liver disease and insulin resistance

VAP cholesterol test helps find link between a rare gene mutation and heart protection

New test predicts how breast cancer patients respond to chemotherapy

Fibroblasts invade at a snail's pace

Opposite approach to asthma treatment may be in order

Genetic interactions are the key to understanding complex traits

Nitric oxide monitoring does not help most children with asthma

Cylene Pharmaceuticals starts CX-4945 trial - first-in class inhibitor of CK2

Breakthrough on type 1 diabetes development

Discovery of gene mutation that appears to help prevent heart disease

Genetic markers identified for alcohol response

Overweight children may inherit faster eating behaviour

Incyte's selective Janus kinase inhibitor demonstrates rapid and durable clinical benefits in Myelofibrosis patients

Anti-oestrogen drugs may promote more harmful cancer cell behaviour

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

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