Phosphorylation News and Research

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Atypical protein kinase C stabilizes SRC-3 levels in breast cancer cells

A new study provides valuable insight into a previously undescribed mechanism that regulates a prominent cancer-associated protein.

28 Feb 2008

New insight into the fundamentals of Parkinson's disease

A single change in a protein may play a role in whether someone develops Parkinson's disease, say University of Florida Genetics Institute researchers writing in a recent issue of the Proceedings of the National Academy of Sciences.

27 Feb 2008

High zinc status in lung cells slows growth and induces DNA

Researchers at the University of Maryland at College Park have discovered that Normal Human Bronchial Epithelial (NHBE) cells cultured in medium with elevated zinc level, at the high end of plasma zinc attainable by oral supplementation, demonstrated inhibition of cell growth, up-regulation of growth arrest and DNA damage-induced gene (Gadd45) mRNA and protein expression, and blockage of G2/M cell cycle progression.

26 Feb 2008

Mutation in TDP-43 gene may play role in common dementia

Scientists at Washington University School of Medicine in St. Louis have linked a mutation in a gene known as TDP-43 to an inherited form of amyotrophic lateral sclerosis (ALS), the neurodegenerative condition often called Lou Gehrig's disease.

21 Feb 2008

Researchers unravel mystery of cell division

Experts in mitosis (cell division) at the University of Virginia Health System have made discoveries that explain how one protein the kinase Aurora B could have such a large role in guiding and policing the process of cell division.

25 Jan 2008

Sleep plays a critical role in the brain's ability to learn

Most people know it from experience: After so many hours of being awake, your brain feels unable to absorb any more-and several hours of sleep will refresh it.

21 Jan 2008

Evolution with a restricted number of genes

The development of higher forms of life would appear to have been influenced by RNA polymerase II.

17 Dec 2007

Pathogens use previously undescribed mechanism to sabotage host immune system

New research identifies a previously unknown enzymatic mechanism that subverts the early host immune response and promotes pathogenicity by manipulating a common signaling pathway in host cells.

10 Dec 2007

Hydrogen sulfide provides clues to a longer life

Hydrogen sulfide, or H2S, the chemical that gives rotten eggs their sulfurous stench - and the same compound that researchers at Fred Hutchinson Cancer Research Center successfully have used to put mice into a state of reversible metabolic hibernation - has now been shown to significantly increase life span and heat tolerance in the nematode worm, or C. elegans.

4 Dec 2007

From successful aging to severe dementia

A recently published special issue of the Journal of Alzheimer's Disease contains the contributions from experts in the field of aging, dementia and Alzheimer's disease, who attended the "Fourth Annual Meeting on Brain aging and Dementia - From successful aging to severe dementia”, Held in Perugia in October 2006 under the auspices of the Italian Psychogeriatric Association, a member of the International Psychogeriatric Association, the meeting celebrates the centenary of Alzheimer's first description of the disease.

16 Nov 2007

Bacteria use plant defence for genetic modification

Bacteria that cause tumours in plants modify plant genomes by skilfully exploiting the plants' first line of defence.

22 Oct 2007

Simplest circadian clocks operate via orderly phosphate transfers

Researchers at Harvard University and the Howard Hughes Medical Institute have found that a simple circadian clock found in some bacteria operates by the rhythmic addition and subtraction of phosphate groups at two key locations on a single protein.

4 Oct 2007

Brugia malayi's secrets revealed

An international team of researchers has revealed the genetic secrets of one of the world's most debilitating human parasites, Brugia malayi (B. malayi), which the World Health Organization estimates has seriously incapacitated and disfigured more than 40 million people around the globe.

21 Sep 2007

Mechanism identified that plays a critical role in multiple myeloma cell cycle and survival

Researchers at Emory University's Winship Cancer Institute are the first to discover a mechanism that plays a critical role in the multiple myeloma cell cycle and survival.

11 Sep 2007

All eukaryotic kinases share 1 common set of substrates

Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death.

24 Aug 2007

Memory storage molecule PKMzeta stores memories in neocortex

The memory storage molecule PKMzeta maintains long-term memories in the neocortex and its presence is continually required in order for the memory to endure, according to a finding by researchers at the Weizmann Institute in Rehovot, Israel and SUNY Downstate Medical Center in Brooklyn, New York.

17 Aug 2007

Metformin kills some cancer cells

Researchers at the University of Pennsylvania School of Medicine have found that a commonly prescribed diabetes drug kills tumor cells that lack a key regulatory gene called p53.

16 Aug 2007

Chromatin remodeling complex connected to DNA damage control

When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell.

12 Aug 2007

New pathway for inflammation-induced cancer

A well-known inflammatory protein spawns an enzyme that inactivates two tumor-suppressing genes, ultimately triggering production of new blood vessels to nourish breast cancer cells, researchers at The University of Texas M. D. Anderson Cancer Center report in the August edition of the journal Cell .

11 Aug 2007

Unlocking proteins from their cellular shell

Applying physical stress to cells, researchers at the University of Pennsylvania have demonstrated that everyday forces can alter the structure of proteins tucked within cells, unfold them and expose new targets in the fight against disease.

3 Aug 2007