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Ashwell receptor plays key role in reducing coagulation abnormalities during infection and sepsis

In research that solves the longest-standing mystery in glycobiology - a field that studies complex sugar chains called glycans - researchers at the University of California, San Diego School of Medicine have discovered that a molecule in the liver of all animals, called the Ashwell receptor, is critical in helping the body fight off the abnormal and lethal blood clotting caused by bacterial infection.

19 May 2008

Mending tendons without surgery

James McGillicuddy was not getting good news. Three years after arriving at Stanford as one of the nation's top high school football recruits, he'd been stuck on the sidelines the entire time by a torn tendon that, even with two surgeries, just wouldn't stay fixed. More surgery would not help, his doctors told him, but they did have one last option to offer him.

21 Apr 2008

Naftidrofuryl for leg pain

Patients with pain caused by narrowed arteries in their legs have 37% more pain-free walking if they take naftidrofuryl (200mg three times a day) than those taking placebos, a Cochrane Review has found.

17 Apr 2008

New molecule could be key to anti-heart attack drug

When too many blood platelets stick together in the bloodstream, they form dangerous clots that can clog blood vessels and cause a heart attack. If a clot doesn't get dissolved or rapidly removed, it can cause permanent damage or even death.

17 Apr 2008

Study results on novel drug-eluting stent coated with a biodegradable polymer

"Real-world" use of a novel drug-eluting stent coated with a biodegradable polymer is associated with good clinical outcomes, according to one-year data from a large international registry.

1 Apr 2008

Drug-eluting stents outperform bare-metal stents

New evidence from a large randomized study is answering important questions about the best approach to percutaneous coronary intervention (PCI) in patients with a type of heart attack known as ST-segment-elevation myocardial infarction (STEMI).

31 Mar 2008

Aspirin/NSAID interaction in treatment for second stroke

Stroke patients who use ibuprofen for arthritis pain or other conditions while taking aspirin to reduce the risk of a second stroke undermine aspirin's ability to act as an anti-platelet agent, researchers at the University at Buffalo have shown.

13 Mar 2008

World's newest flexible drug-eluting stent used by Methodist cardiologists

A more flexible drug-eluting stent studied in clinical trials at the Methodist DeBakey Heart & Vascular Center has been approved by the FDA, and Methodist physicians were the first in Houston to implant the new device.

12 Mar 2008

Post-stroke clot-busting therapy beneficial for patients on aspirin

Patients given a clot-busting drug following stroke appear to have better outcomes if they were already taking anti-platelet medications, despite an apparent increased risk for bleeding in the brain, according to an article posted online that will appear in the May 2008 print issue of Archives of Neurology.

11 Mar 2008

Discovery of new way to control growth rate of replacement tissue and formation of new blood vessels

Researchers have discovered a way to control the growth rate of replacement tissue and the formation of new blood vessels, which solves one of the vexing problems of growing replacement tissue to treat injuries and trauma in humans.

10 Mar 2008

Fugitive cancer cells can be blocked by stopping blood cells that aid them

Cancer cells get a helping hand from platelets, specialized blood cells involved in clotting.

10 Mar 2008

Integrin beta3 protein yields clues to autism

Many children with autism have elevated blood levels of serotonin - a chemical with strong links to mood and anxiety.

6 Mar 2008

Serum fibrosis markers correlate with liver fibrosis stage in patients with advanced chronic hep C

A prospective study of patients with advanced chronic hepatitis C (CHC) revealed that a 3-variable model of serum fibrosis markers, including serum HA, TIMP-1 and platelet count, could identify cirrhosis with better accuracy than other published models.

4 Mar 2008

Discovery of previously unknown mechanism that leads to cleft palate

By creating a genetic mutation in zebrafish, University of Oregon scientists say they've discovered a previously unknown mechanism for cleft palate, a common birth defect in humans that has challenged medical professionals for centuries.

12 Feb 2008

Patients at risk of adverse events within 3 months after stopping certain ACS therapy

Patients who receive the anti-platelet medication clopidogrel following an acute coronary syndrome (such as heart attack) appear to be at greater risk of a heart attack or death in the first 90 days after stopping clopidogrel treatment, according to a study in the February 6 issue of JAMA: The Journal of the American Medical Association.

7 Feb 2008

Half of patients undergoing cerebrovascular stent placement do not respond well to clopidogrel

A study by researchers at Rush University Medical Center, published in the February issue of the American Journal of Neuroradiology, finds that half of patients undergoing cerebrovascular stent placement did not respond well to clopidogrel.

7 Feb 2008

Novel drug romiplostim significantly improves treatment of dangerous blood disorder

Two clinical trials of the novel drug romiplostim (Nplate) show that it significantly improved platelet levels in patients with chronic immune thrombocytopenic purpura (ITP), a hematologic disorder that can cause uncontrolled bleeding.

5 Feb 2008

Ascal (calcium carbasalate) not safer than aspirin

Changing prescription of low-dose aspirin into calcium carbasalate (brand name: Ascal) to prevent peptic ulcerations is not useful. Peptic ulcers are evenly distributed among users of calcium carbasalate and aspirin, for secondary prevention of myocardial infarction.

5 Feb 2008

Drug effective for hepatitis C patients with low platelets

For patients with hepatitis C, having a low blood platelet count is a frequent complication associated with advanced disease.

2 Jan 2008

Bosutinib safe, effective for chronic myelogenous leukemia

A new drug for chronic myelogenous leukemia works for patients who have developed resistance to frontline therapy and causes fewer side effects than other medications in its class, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports at the 49th annual meeting of the American Society of Hematology.

12 Dec 2007