Polymerase News and Research

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SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

A recent study under review at Nature Portfolio and posted to the Research Square* preprint server depicted how cellular nucleic acid-binding protein (CNBP) inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

3 May 2022

Study explores which occupations had the greatest risk of SARS-CoV-2 infection and how relative differences varied over the pandemic

Researchers investigated occupations at the highest risk for SARS-CoV-2 infection.

3 May 2022

Effectiveness of ChAdOx1-S COVID-19 booster vaccine

Researchers assessed the effectiveness of ChAdOx1-S COVID-19 booster vaccination.

3 May 2022

Long COVID is characterized SARS-CoV-2 antigen persistence in the gut mucosa

A new study published in the journal Gastroenterology used upper and lower gastrointestinal endoscopy to assess whether gut antigen persistence leads to post-acute COVID-19 in patients with or without post-acute COVID-19 symptoms.

3 May 2022

Prior SARS-CoV-2 infection provides substantial and sustained protection from Omicron hospitalization

A population-level study conducted on residents of the Quebec province, Canada, has demonstrated that prior infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces robust and long-lasting protection against omicron re-infection and hospitalization. The level of protection further increases with coronavirus disease 2019 (COVID-19) vaccination.

3 May 2022

New method increases efficiency of gene editing while minimizing DNA deletion sizes

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists working on CRISPR/Cas9-mediated gene editing technology have developed a method to increase efficiency of editing while minimizing DNA deletion sizes, a key step toward developing gene editing therapies to treat genetic diseases.

2 May 2022

Novel wearable sensor can detect two key biomarkers of infection in sweat

University of Texas at Dallas bioengineers in collaboration with EnLiSense LLC have designed a wearable sensor that can detect two key biomarkers of infection in human sweat, a significant step toward making it possible for users to receive early warnings of infections such as COVID-19 and influenza.

2 May 2022

Tracking BA.2.12.1 🦠 by partial ORF1ab gene 🧬 target failure (pOGTF)

Scientists from the United States have recently identified a novel approach to rapidly and accurately detect the omicron BA.2.12.1 sub-lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical samples.

2 May 2022

Estimating COVID-19 case prevalence in New York City

Researchers estimated the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in New York City (NYC).

2 May 2022

Neutralizing antibodies produced following COVID-19 BNT162b2 vaccine found to activate complement cascade

Researchers investigated the complement component 1q (C1q) binding and subsequent complement activation by neutralizing antibodies (nAbs) produced following COVID-19 vaccination.

2 May 2022

SARS-CoV-2 viral shedding varies widely in asymptomatic and mildly ill patients

In a recent study published in the Nature Microbiology journal, researchers assessed the longitudinal viral dynamics in asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

1 May 2022

Probenecid shows activity against respiratory syncytial virus

A new study describes the antiviral activity of the approved drug probenecid against respiratory syncytial virus.

29 Apr 2022

Poor asthma control triggered by SARS-CoV-2

In a new study, researchers noted that COVID-19 could trigger poor pediatric asthma control.

29 Apr 2022

Study evaluates hybridization probe capture for enriching coronavirus genomic material in bat oral and rectal swabs

Researchers surveilled coronaviruses found in bats via targeted genomic sequencing.

29 Apr 2022

Clinical characteristics of immunocompromised patients infected with the SARS-CoV-2 Omicron variant

Researchers examined the characteristics and outcomes of COVID-19 in immunocompromised patients.

29 Apr 2022

Artificial circular RNAs found to bypass cellular antiviral responses

Researchers produced artificial circular ribonucleic acid sponges in a permuted intron-exon system and showed that these did not activate innate immunity.

29 Apr 2022

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

A new study published in Marine Drugs evaluated the inhibitory effect of three polysaccharides, crude polysaccharide from Hizikia fusiforme (CPHF), crude polysaccharide from Sargassum horneri (CPSH), and crude polysaccharide from abalone viscera (CPAV) on the propagation of SARS-CoV-2 in vitro.

28 Apr 2022

Polymerase News and Research

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

Study explores which occupations had the greatest risk of SARS-CoV-2 infection and how relative differences varied over the pandemic

Effectiveness of ChAdOx1-S COVID-19 booster vaccine

Long COVID is characterized SARS-CoV-2 antigen persistence in the gut mucosa

Prior SARS-CoV-2 infection provides substantial and sustained protection from Omicron hospitalization

New method increases efficiency of gene editing while minimizing DNA deletion sizes

Novel wearable sensor can detect two key biomarkers of infection in sweat

Tracking BA.2.12.1 🦠 by partial ORF1ab gene 🧬 target failure (pOGTF)

Estimating COVID-19 case prevalence in New York City

Neutralizing antibodies produced following COVID-19 BNT162b2 vaccine found to activate complement cascade

SARS-CoV-2 viral shedding varies widely in asymptomatic and mildly ill patients

Probenecid shows activity against respiratory syncytial virus

Poor asthma control triggered by SARS-CoV-2

Study evaluates hybridization probe capture for enriching coronavirus genomic material in bat oral and rectal swabs

Clinical characteristics of immunocompromised patients infected with the SARS-CoV-2 Omicron variant

Artificial circular RNAs found to bypass cellular antiviral responses

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

Findings of the HITCH randomized clinical trial show lack of improvement in COVID-19 on temporary androgen suppression

Evidence of accelerated epigenetic age in SARS-CoV-2-positive patients

How severity and progression of COVID-19 affect cytokine profiles in pregnant women

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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