Premature Ovarian Failure News and Research

RSS

Premature ovarian failure (POF) is a condition that is characterized by the ovaries ceasing to function before the age of 40. This is distinct from premature menopause as women still have an occasional period and it is possible for them to get pregnant. POF affects approximately 1 in 100 women of childbearing age younger than 40 years old.

Biological underpinnings of a reproductive disorder caused by mutation of autism gene

A University of California, Riverside, study has identified the biological underpinnings of a reproductive disorder caused by the mutation of a gene.

5 Apr 2023

Study aims to understand how female fertility is established at the molecular level

Fertility is finite for mammalian females. From birth, females possess a limited number of primordial follicles, collectively called the ovarian reserve. Within each follicle is an oocyte that eventually becomes an egg. But with age, the follicles in the ovarian reserve decrease.

11 Aug 2022

Study finds higher risk of pre-eclampsia, hypertension in pregnancies derived from frozen embryos

A large cohort study drawn from the national IVF registry of France, which included almost 70,000 pregnancies delivered after 22 weeks gestation between 2013 and 2018, has found a higher risk of pre-eclampsia and hypertension in pregnancies derived from frozen-thawed embryos.

30 Jun 2021

New blood test more accurately predicts the final menstrual period

Researchers in the United States have demonstrated that a new blood test could be a superior marker of the time to menopause than bleeding patterns, or previously available tests.

22 Jan 2020

"Jumping genes" within eggs determine their survival

Females are born with a finite supply of eggs and with age the genetic quality of the eggs decline say researchers from Carnegie Institute. The study from researchers Marla Tharp, Safia Malki, and Alex Bortvin was published in the latest issue of Nature Communications. The study was titled, “Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity.”

16 Jan 2020

Research shows how the body tries to eliminate egg cells of poorest quality

A woman's supply of eggs is finite, so it is crucial that the quality of their genetic material is ensured. New work from Carnegie's Marla Tharp, Safia Malki, and Alex Bortvin elucidates a mechanism by which, even before birth, the body tries to eliminate egg cells of the poorest quality.

16 Jan 2020

Prenatal exposures to BPA may pose threat to human ovarian function

While previous studies have shown the adverse health effects of prenatal exposure to the industrial chemical bisphenol A, there is little evidence surrounding effects specifically on ovarian function.

14 Feb 2019

Prenatal famine exposure may lead to early menopause and premature ovarian failure

Previous studies have demonstrated that fetal malnutrition can lead to adult chronic disorders such as type 2 diabetes and coronary artery disease. A new study out of China now suggests that it also can lead to early menopause and premature ovarian failure.

5 Dec 2018

UW-Madison researcher explores how female fertility is affected by development of the ovary in mice

When Joan Jorgensen was an undergraduate at the University of Wisconsin–Madison, her roommate confided that she had just one period before going through menopause in high school.

3 Aug 2018

Identifying gene variants that contribute to ovarian reserve may improve female fertility

For a woman to conceive and deliver a healthy baby, thousands of genes have to work correctly and together. These include genes controlling fertility factors such as the ovarian reserve, the capacity of ovaries to produce viable and fertilizable oocytes, or eggs.

20 Jun 2018

Researchers discover quirk of cell aging that could help detect late-onset Alzheimer's

Researchers at The University of Texas Health Science Center at Houston School of Dentistry and McGovern Medical School have discovered a previously unknown characteristic of brain-cell aging that could help detect late-onset Alzheimer's disease decades before symptoms begin.

30 Oct 2017

Existing drug may one day protect premenopausal women from infertility after cancer treatments

An existing drug may one day protect premenopausal women from life-altering infertility that commonly follows cancer treatments, according to a new study.

1 Sep 2017

Study shows promise for successful ovarian transplantation in future

Approximately 11% of women worldwide suffer from premature ovarian failure. This can have many different causes: chemotherapy administered for a malignant disease might irreversibly damage the ovaries and, because of the advances in modern cancer therapy, the number of young women surviving cancer is on the increase.

2 Nov 2016

Hormonal therapy may protect women's ovaries, increase chances of pregnancy after breast cancer treatment

Young women undergoing chemotherapy for breast cancer may be more likely to remain fertile if they also receive hormonal treatment, according to new research presented to the 2015 European Cancer Congress on Monday and published simultaneously in Annals of Oncology.

28 Sep 2015

Discovery opens door to more targeted, effective treatments for cancer

In a discovery that could lead to more targeted and effective treatments for certain lung and prostate cancers, researchers at the University of Virginia School of Medicine have identified two new cancer-causing gene mutations - mutations that may be particularly susceptible to cancer-fighting drugs already approved by the federal Food and Drug Administration. One of the gene mutations also may play a key role in early menopause.

24 Sep 2015

Scientists solve mystery about the origin of ovarian cell

Scientists at the National Institutes of Health have solved a long-standing mystery about the origin of one of the cell types that make up the ovary. The team also discovered how ovarian cells share information during development of an ovarian follicle, which holds the maturing egg.

7 May 2015

Adding goserelin drug to chemotherapy prevents early menopause in young women with breast cancer

Early menopause can be prevented and fertility may be preserved in young women with early stage breast cancer, according to a study published today in The New England Journal of Medicine

5 Mar 2015

Tel Aviv University study throws spotlight on gene mutation responsible for premature ovarian failure

Premature ovarian failure, also known as primary ovarian insufficiency (POI), affects 1% of all women worldwide. In most cases, the exact cause of the condition, which is often associated with infertility, is difficult to determine.

18 Dec 2014

Studies show increased risk of pregnancy-induced hypertension in egg donation patients

With an ever-ageing female patient population, egg donation is an increasingly common treatment in infertility. ESHRE's own annual reports on fertility treatments in Europe show a rise in egg donation cycles from 15,028 in 2007 to 24,517 in 2010 (to 4.05% of all treatments). This proportion is still some way behind the USA, where egg donation now accounts for around 12% of all treatments.

2 Jul 2014

Goserelin can help reduce risk of early menopause in young women with breast cancer

Among young women treated for breast cancer, one of the most distressing side effects of chemotherapy is early menopause.

31 May 2014