Proliferation News and Research

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Decreased expression of tumor suppressor gene PTEN transforms neurofibromas into cancer

Researchers at UCLA's Jonsson Comprehensive Cancer Center showed for the first time that the loss or decreased expression of the tumor suppressor gene PTEN plays a central role in the malignant transformation of benign nerve tumors called neurofibromas into a malignant and extremely deadly form of sarcoma.

14 Oct 2009

SANUWAVE presents findings on extracorporeal shock wave stimulation of osteoprogenitor cells

SANUWAVE, Inc., an emerging medical technology company focused on the development and commercialization of non-invasive, biological response activating devices in the regenerative medicine area, reported that scientific findings titled “Extracorporeal Shock Wave Stimulation of Osteoprogenitor Cells” were presented at the 2009 International Bone-Tissue-Engineering Congress (“Bone-Tec”) in Hannover, Germany, which was held October 9-11, 2009.

13 Oct 2009

Researchers find how KEAP1 tumor suppressor works

A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports this week in the journal Molecular Cell.

12 Oct 2009

NHLBI awards $16.7 million to develop new clinical strategies in stem cell therapy

9 Oct 2009

Hutchinson Center scientists awarded $16.7M to develop progenitor and stem cell tools

The National Heart, Lung and Blood Institute has awarded a total of $16.7 million to Irwin Bernstein, M.D., and Beverly Torok-Storb, Ph.D., both members of the Clinical Research Division at Fred Hutchinson Cancer Research Center. The Hutchinson Center grants represent part of a $170 million effort involving 18 teams of research scientists dedicated to developing stem- and progenitor-cell tools and therapies.

8 Oct 2009

New study to boost immune cells for pathogen resistance and vaccine efficacy in elderly

A new study from the Trudeau Institute in Saranac Lake, New York, demonstrates that immune system cells important for both pathogen resistance and vaccine efficacy live longer in older animals but because of this longevity acquire functional defects. The work may provide new targets for boosting immune system function in older individuals.

6 Oct 2009

Scientists uncover the role of first-responder molecule involved in repairing DNA strand breaks

Scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory and the Scripps Research Institute have uncovered the role played by the least-understood part of a first-responder molecule that rushes in to bind and repair breaks in DNA strands, a process that helps people avoid cancer.

5 Oct 2009

Study shows that GSK-3 gene determines the total number of neurons required for brain

In populating the growing brain, neural stem cells must strike a delicate balance between two key processes - proliferation, in which the cells multiply to provide plenty of starting materials - and differentiation, in which those materials evolve into functioning neurons.

5 Oct 2009

Professor's research to transform mobile phones into powerful medical devices

Cell phones have come a long way in the last decade. Today, one can talk, text message, shoot photos and video, send and receive e-mail, and even access the Web. Now imagine a cell phone that can be used to monitor diseases like HIV or malaria and to test water quality after a major disaster like a hurricane or earthquake.

3 Oct 2009

Molecular mechanisms of BN108 and timosaponin AIII described in a journal

Bionovo, Inc. today announced the publication in the peer-reviewed, open-access journal Public Library of Science One (PLoS ONE) of a paper describing the molecular mechanisms underlying the selective cytotoxic activity of its drug candidate BN108 and its active compound, timosaponin AIII.

2 Oct 2009

Gamida Cell publishes article evaluating Stemex for leukemia and lymphoma

Gamida Cell announced today the publication of an article evaluating carlecortemcel-l, the generic name of what is widely known as "StemEx", as a therapy for blood cancers such as leukemia and lymphoma. The article, carlecortemcel-l, an ex vivo expanded umbilical cord blood cell graft for allogeneic transplantation, written by Dr. Ka Wah Chan and Dr. Demetrios Petropoulos, will be published in the November 2009 issue of Expert Opinion on Biological Therapy.

1 Oct 2009

National Institutes of Health awards $16.8 million grant to Hutchinson Center/UW group

The National Heart, Lung and Blood Institute of the National Institutes of Health has awarded a $16.8 million, seven-year grant to launch a bicoastal research partnership between Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium and Children's Hospital of Philadelphia.

30 Sep 2009

Synta commences Phase 1/2 clinical study of novel Hsp90 inhibitor in hematologic malignancies

Synta Pharmaceuticals Corp., a biopharmaceutical company focused on discovering, developing, and commercializing small molecule drugs to treat severe medical conditions, today announced that it has initiated a Phase 1/2 clinical study of its novel heat shock protein 90 (Hsp90) inhibitor, STA-9090 in hematologic malignancies with a once-a-week dosing schedule.

29 Sep 2009

Increasing insulin levels can aid muscle building in the elderly

Recently, scientists have recognized that loss of responsiveness to insulin plays a major role in the loss of physical strength that occurs as people grow older. Now, University of Texas Medical Branch at Galveston researchers have demonstrated that by increasing insulin levels above the normal range in elderly test subjects, they can restore the impaired muscle-building process responsible for age-related physical weakness.

28 Sep 2009

M.D. Peled to market Universal Detection Technology's Bio-Weapon Detection Systems in Israel

Universal Detection Technology, a developer of early-warning monitoring technologies to protect people from bioterrorism and other infectious health threats and provider of counter-terrorism consulting and training services, announced today that it has received its first purchase order from the Company’s newly signed Israeli Distributor, M.D. Paled.

28 Sep 2009

Growing public support for the use of ignition interlocks on the cars of drunk drivers: IIHS study

While a study released last week by the Insurance Institute for Highway Safety (IIHS) indicates growing public support for the use of ignition interlocks on the cars of drunk drivers, a growing body of justice officials and policymakers say the trend is actually dealing with the people--not just the cars--when it comes to mitigating the social and financial costs of the DUI epidemic.

25 Sep 2009

Pre-clinical data demonstrates advantages of Combo Stent

OrbusNeich announced today that pre-clinical data involving porcine coronary models demonstrate that the company's Combo Bio-engineered Sirolimus Eluting Stent (Combo Stent) may offer advantages to the Cypher(R) sirolimus eluting stent and the XIENCE(TM) V everolimus eluting stent.

24 Sep 2009

Acetaminophen can prevent age-related problems

Recent studies conducted by Dr. Eric Blough and his colleagues at Marshall University have shown that use of the common pain reliever acetaminophen may help prevent age-associated muscle loss and other conditions.

24 Sep 2009

TSPs can block cancer-triggering proto-oncogenes

A tiny bit of genetic material with no previously known function may hold the key to stopping the spread of cancer, researchers at Yale School of Medicine and Sichuan University in Chengdu, China report in two papers in the September 7-11 issue of Proceedings of the National Academy of Sciences.

24 Sep 2009

Researchers visualize vasculature within native liver cyst walls of human ADPKD patients

As part of an effort to develop effective medical therapies that block the progression of liver cyst growth in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD), researchers at the University of Colorado Anschutz Medical Center have found that the liver cyst walls develop and maintain a vasculature as they grow out from the body of the liver and that factors released by epithelial cells that line the liver cyst wall lumen can drive the proliferation and development of vascular endothelial cells.

24 Sep 2009

Proliferation News and Research

Decreased expression of tumor suppressor gene PTEN transforms neurofibromas into cancer

SANUWAVE presents findings on extracorporeal shock wave stimulation of osteoprogenitor cells

Researchers find how KEAP1 tumor suppressor works

NHLBI awards $16.7 million to develop new clinical strategies in stem cell therapy

Hutchinson Center scientists awarded $16.7M to develop progenitor and stem cell tools

New study to boost immune cells for pathogen resistance and vaccine efficacy in elderly

Scientists uncover the role of first-responder molecule involved in repairing DNA strand breaks

Study shows that GSK-3 gene determines the total number of neurons required for brain

Professor's research to transform mobile phones into powerful medical devices

Molecular mechanisms of BN108 and timosaponin AIII described in a journal

Gamida Cell publishes article evaluating Stemex for leukemia and lymphoma

National Institutes of Health awards $16.8 million grant to Hutchinson Center/UW group

Synta commences Phase 1/2 clinical study of novel Hsp90 inhibitor in hematologic malignancies

Increasing insulin levels can aid muscle building in the elderly

M.D. Peled to market Universal Detection Technology's Bio-Weapon Detection Systems in Israel

Growing public support for the use of ignition interlocks on the cars of drunk drivers: IIHS study

Pre-clinical data demonstrates advantages of Combo Stent

Acetaminophen can prevent age-related problems

TSPs can block cancer-triggering proto-oncogenes

Researchers visualize vasculature within native liver cyst walls of human ADPKD patients

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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