Proliferation News and Research

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Study identifies a promising target for development of vaccine against spotted fever

A protein found in cells of the hard tick Amblyomma sculptum, the main vector of the bacterium that causes Brazilian spotted fever (also known as Rocky Mountain spotted fever), is essential to the tick's survival while feeding, making it a promising target for development of a vaccine, according to an article published in the journal Parasites & Vectors.

7 Jun 2023

Study reveals intricate pathway that dictates the cell’s ability to be resilient and plastic

Researchers have long thought that once a cell starts down its path of differentiation, growing into a skin cell or a liver cell or a neuron, that path could not be changed.

7 Jun 2023

Research opens door to new, more efficient drug combinations for acute myeloid leukemia

Acute myeloid leukemia (AML) is a very aggressive disease in which cells proliferate abnormally, invading the bone marrow and interfering with normal blood cell production. It is the most common acute leukemia in adults with the worst prognosis.

5 Jun 2023

Study shows efficacy and safety of novel FolRα-targeting antibody drug conjugate in recurrent epithelial ovarian cancer

Updated dose expansion data of the phase I STRO-002-GM1 study have been presented today by Ana Oaknin, Principal Investigator of the Vall d'Hebron Institute of Oncology's (VHIO) Gynecological Malignancies Group, on the ground at the 2023 Annual Meeting of the American Society of Clinical Oncology (ASCO), 2-6 June in Chicago, USA.

4 Jun 2023

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Blood-brain barrier breakdown in multiple sclerosis leads to immune cell infiltration into the central nervous system. Antigen presentation at the barrier promotes CD8+ T cell entry, triggering focal breakdown and hindering their invasion.

4 Jun 2023

Researchers characterize a unique molecular mechanism of early stages of programmed cell death

Researchers have for the first time characterized a unique molecular mechanism of the early stages of programmed cell death or apoptosis, a process which plays a crucial role in prevention of cancer.

2 Jun 2023

Exposure to Agent Orange associated with increased risk of myeloproliferative neoplasms in veterans

Research conducted at Georgetown University's Lombardi Comprehensive Cancer Center and the Washington DC VA Medical Center on a database of veterans exposed to Agent Orange found an association for an increased risk of developing myeloproliferative neoplasms (MPNs), which are acquired stem cell disorders that can lead to overproduction of mature blood cells complicated by an increased risk of blood clots in arteries and veins.

2 Jun 2023

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

Study suggests licorice-derived liquiritigenin has breast cancer prevention potential for high-risk postmenopausal women

Researchers evaluated the potential of three licorice (Glycyrrhiza) species, i.e., G. glabra (GG), G. uralensis (GU), and G. infata (GI), and hops (Humulus lupulus), and their main bioactive polyphenols, to prevent breast malignancy.

1 Jun 2023

The National Environmental Assessment Reporting System: reporting foodborne illness outbreaks at retail food establishments during 2017–2019

Researchers summarized environmental health data collected by the United States (U.S.) state and local health departments.

1 Jun 2023

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

The immunopathology of post-acute sequelae of SARS-CoV-2 infection (PASC).

31 May 2023

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Melatonin, a hormone derived from the pineal gland, has diverse effects on cellular processes. This review explores its potential role as an epigenetic regulator, particularly in modulating DNA methylation, and suggests its use in combination therapy as a novel anticancer strategy.

30 May 2023

Proliferation News and Research

Study identifies a promising target for development of vaccine against spotted fever

Study reveals intricate pathway that dictates the cell’s ability to be resilient and plastic

Research opens door to new, more efficient drug combinations for acute myeloid leukemia

Study shows efficacy and safety of novel FolRα-targeting antibody drug conjugate in recurrent epithelial ovarian cancer

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Researchers characterize a unique molecular mechanism of early stages of programmed cell death

Exposure to Agent Orange associated with increased risk of myeloproliferative neoplasms in veterans

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

Study suggests licorice-derived liquiritigenin has breast cancer prevention potential for high-risk postmenopausal women

The National Environmental Assessment Reporting System: reporting foodborne illness outbreaks at retail food establishments during 2017–2019

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Study identifies a novel druggable signaling molecule involved in obesity and diabetes

Researchers explore the possibility of treating lung cancer by targeting telomeres

Looking at cancer drugs to help put the brakes on classic indicators of aging

GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

Metabolic sensors may play a role in the development of Alzheimer's disease, study suggests

Researchers receive $2.3 million to continue development of a new ‘glyco-immune’ checkpoint inhibitor

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

Unlocking the gut clock: How circadian rhythms and gut microbiota team up to impact human health

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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