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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

New data on use of PBD dimers as warheads in ADCs presented at AACR annual meeting

Spirogen, a leading oncology-focused company developing DNA sequence targeted agents, and BioAtla LLC, a San Diego headquartered antibody therapeutics developer, today announced new data on the use of pyrrolobenzodiazepine (PBD) dimers as warheads in antibody drug conjugates (ADCs) at the annual meeting of the American Association for Cancer Research (AACR) in Washington, DC.

11 Apr 2013

Computational simulations can help understand, treat cardiac rhythm disorders

Computational models of the human heart can be very useful in studying not just the basic mechanisms of heart function, but also to analyze the heart in a diseased state, and come up with methods for diagnosis and therapy.

11 Apr 2013

Pfizer's breast cancer compound wins FDA's Breakthrough Therapy designation

Pfizer Inc. announced today its investigational compound palbociclib (PD-0332991), an oral and selective inhibitor of cyclin dependent kinases (CDK) 4 and 6, has received Breakthrough Therapy designation by the United States Food and Drug Administration for the potential treatment of patients with breast cancer.

From Pfizer, Inc. 11 Apr 2013

First-in-humans study introduces next generation cell therapy for heart failure patients

Translating a Mayo Clinic stem-cell discovery, an international team has demonstrated that therapy with cardiopoietic (cardiogenically-instructed) or "smart" stem cells can improve heart health for people suffering from heart failure.

11 Apr 2013

Coenzyme Q10 offsets cellular changes that are linked to side-effect of some statin drugs: Study

A laboratory study has shown for the first time that coenzyme Q10 offsets the cellular changes that are linked to a side-effect of some statin drugs - an increased risk of adult-onset diabetes.

11 Apr 2013

Study: microRNA is designed to stop proliferation of prostate cancer cells

The most recent in a series of studies from a team at the UC Davis Comprehensive Cancer Center has shown that a single molecule is at the heart of one of the most basic survival tactics of prostate cancer cells.

10 Apr 2013

Research: African-Americans with ABCA7 gene variant have double risk of developing AD

African-Americans with a variant of the ABCA7 gene have almost double the risk of developing late-onset Alzheimer's disease compared with African-Americans who lack the variant.

10 Apr 2013

Research shows omega-3 fatty acids stop proliferation of triple-negative breast cancer cells

Researchers from Fox Chase Cancer Center have found that omega-3 fatty acids and their metabolite products slow or stop the proliferation, or growth in the number of cells, of triple-negative breast cancer cells more effectively than cells from luminal types of the disease.

10 Apr 2013

Study shows human blood contains 1000’s of autoantibodies to clear cellular debris caused by injury, disease

In a study that suggests a new frontier in immunology, scientists at the University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine (UMDNJ-SOM) report on evidence that shows human blood contains thousands of autoantibodies that bind specifically to antigens from organs and tissues all over the body and act to clear cellular debris that results from injury and disease.

10 Apr 2013

Tiny proteins prevent bacterial gene transcription

In the search for new antibiotics, researchers are taking an unusual approach: They are developing peptides, short chains of protein building blocks that effectively inhibit a key enzyme of bacterial metabolism.

10 Apr 2013

CYP1B1 protein prevents head and neck cancers, say researchers

Head and neck cancers typically begin in squamous cells that line moist surfaces inside the mouth, nose and throat. Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States, and it is sometimes preceded by the appearance of changes inside the oral cavity called precancerous lesions.

10 Apr 2013

Researchers discover novel protein that governs metastasis and chemoresistance in pediatric bone cancer

Human osteosarcoma samples are hard to come by, making the disease difficult to study. However, K9 bone cancer is genetically indistinguishable from the human form of the disease, and over 10,000 canine patients develop the disease every year.

10 Apr 2013

New combination therapy could help restore vision

Researchers have discovered that using two kinds of therapy in tandem may be a knockout combo against inherited disorders that cause blindness. While their study focused on man's best friend, the treatment could help restore vision in people, too.

10 Apr 2013

New study shows combination therapy is effective in treating sarcoma tumors

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have found that when given together, a two-drug combination acts synergistically in test animals modeled with sarcoma tumors.

10 Apr 2013

Tumors with excess copies of MYCN highly sensitive to BET bromodomain inhibitors, researchers find

An irregularity within many neuroblastoma cells may indicate whether a neuroblastoma tumor, a difficult-to-treat, early childhood cancer, is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors, Dana-Farber/Children's Hospital Cancer Center scientists will report at the annual meeting of the American Association for Cancer Research in Washington, April 6-10.

10 Apr 2013

AACR recognizes UT MD Anderson professor for contributions to cancer research

Guillermina "Gigi" Lozano, Ph.D., chair and professor in the Department of Genetics at The University of Texas MD Anderson Cancer Center, is the recipient of the 16th annual Women in Cancer Research Charlotte Friend Memorial Lectureship awarded by The American Association for Cancer Research, recognizing her contributions to the field of cancer research and the advancement of women in science.

10 Apr 2013

Research shows UNC1062 blocks Mer survival signaling in melanoma cells

Collaborative research presented by the University of Colorado Cancer Center, the University of North Carolina at Chapel Hill, Harvard Medical School and the University of Pittsburgh, at the American Association for Cancer Research Annual Conference, shows that the protein receptor Mer is overexpressed in melanoma and that the investigational drug UNC1062 blocks Mer survival signaling in these cells, killing them.

10 Apr 2013

Researchers discover genetic variants of heart disorder in some cases of stillbirth

In a first-of-its-kind study, researchers from the United States and Europe discovered genetic mutations associated with long QT syndrome, a genetic abnormality in the heart's electrical system, in a small number of intrauterine fetal deaths, according to a study in the April 10 issue of the Journal of the American Medical Association.

10 Apr 2013

Jeffrey Epstein VI Foundation helps develop mathematical model to study evolution of cancer

The Jeffrey Epstein VI Foundation, a science foundation based in New York City, has helped finance the first mathematical model of how human cancer cells evolve, and more specifically, how they evolve to become immune to inhibitor drug therapy, a popular alternative to chemotherapy.

10 Apr 2013

MD Anderson scientists demonstrate new way to restore tumor suppression

Tumor suppression, the family business of the sibling genes p53, p63 and p73, is undermined from within by the split personalities of p63 and p73, which each produce protein forms that not only block the work of the other two genes but also shut down its own cancer-stifling fraternal twin.

10 Apr 2013

Protein News and Research

Further Reading

New data on use of PBD dimers as warheads in ADCs presented at AACR annual meeting

Computational simulations can help understand, treat cardiac rhythm disorders

Pfizer's breast cancer compound wins FDA's Breakthrough Therapy designation

First-in-humans study introduces next generation cell therapy for heart failure patients

Coenzyme Q10 offsets cellular changes that are linked to side-effect of some statin drugs: Study

Study: microRNA is designed to stop proliferation of prostate cancer cells

Research: African-Americans with ABCA7 gene variant have double risk of developing AD

Research shows omega-3 fatty acids stop proliferation of triple-negative breast cancer cells

Study shows human blood contains 1000’s of autoantibodies to clear cellular debris caused by injury, disease

Tiny proteins prevent bacterial gene transcription

CYP1B1 protein prevents head and neck cancers, say researchers

Researchers discover novel protein that governs metastasis and chemoresistance in pediatric bone cancer

New combination therapy could help restore vision

New study shows combination therapy is effective in treating sarcoma tumors

Tumors with excess copies of MYCN highly sensitive to BET bromodomain inhibitors, researchers find

AACR recognizes UT MD Anderson professor for contributions to cancer research

Research shows UNC1062 blocks Mer survival signaling in melanoma cells

Researchers discover genetic variants of heart disorder in some cases of stillbirth

Jeffrey Epstein VI Foundation helps develop mathematical model to study evolution of cancer

MD Anderson scientists demonstrate new way to restore tumor suppression

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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