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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Cyclacel's CYC065 CDK inhibitor demonstrates potential against breast cancer resistant to trastuzumab

Cyclacel Pharmaceuticals, Inc., today announced the publication of preclinical data in the Proceedings of the National Academy of Sciences (PNAS), demonstrating that cyclin E plays a major role in making Human Epidermal growth factor Receptor 2 positive (HER2+) breast cancer resistant to trastuzumab (Herceptin®), a widely used medicine for breast cancer patients who test positive for HER2.

18 Feb 2011

BioMimetic highlights updates on orthopedic and rehabilitation devices during AAOS meeting

BioMimetic Therapeutics, today announced highlights from its analyst and investor meeting which was held on Thursday, February 17 in San Diego, CA in conjunction with the American Academy of Orthopedic Surgery Annual Meeting.

18 Feb 2011

Researchers identify normal movement mechanisms of PrPC in brain

Researchers at the University of California, San Diego School of Medicine have identified the motors that move non-infectious prion proteins (PrPC) - found within many mammalian cells - up and down long, neuronal transport pathways.

18 Feb 2011

Avenir team discovers how Neisseria meningitidis disseminates into bloodstream

Although, in the majority of cases, the localized presence of Neisseria meningitidis in the throat has no consequence, it can sometimes lead to meningitis or septicaemia. The seriousness of these two infections is driving researchers from around the world to improve their understanding of the mode of operation of this bacterium, which, once it leaves its favourite location becomes extremely dangerous.

18 Feb 2011

Statin drug may help prevent blindness in diabetics

New University of Georgia research has found that a statin drug that is often known by the brand-name Lipitor may help prevent blindness in people with diabetes.

17 Feb 2011

Iris Pharma announces validation of new EIU model of ocular inflammation

Iris Pharma, a world leader CRO specialized in ophthalmology, today announced the validation of the Endotoxin-Induced Uveitis model, a new model of ocular inflammation.

17 Feb 2011

AAN honors three researchers with 2011 Potamkin Prize for dementia study

The American Academy of Neurology is awarding its 2011 Potamkin Prize to three researchers for their work in dementia. Dennis Dickson, MD, with the Mayo Clinic in Jacksonville, Florida, Eva Maria Mandelkow, MD, PhD, and Eckhard Mandelkow, PhD, both of the Max-Planck-Unit for Structural Molecular Biology in Hamburg, Germany, will receive the Award during the AAN's 63rd Annual Meeting in Hawaii, April 9 - 16, 2011.

17 Feb 2011

Study: Cigarette smoking linked to mucus overproduction in patients with chronic bronchitis

Cigarette smoking has been linked with overproduction of mucus associated with chronic bronchitis, according to a study conducted by researchers in New Mexico. The study indicates cigarette smoke suppresses a protein that causes the natural death of mucus-producing cells in the airways of bronchitis patients.

17 Feb 2011

Positive preliminary data from ongoing PSMA ADC phase 1 study against prostate cancer

Progenics Pharmaceuticals, Inc. today reported positive preliminary data from an ongoing phase 1 study of PSMA ADC, an antibody-drug conjugate designed to selectively deliver chemotherapy to cells that express prostate-specific membrane antigen.

17 Feb 2011

Researchers discover substance that reinforces brain's self-healing functions after stroke

The only acute treatment for a stroke currently available is thrombolysis. This uses drugs that dissolve the blood clot responsible for the stroke, but it only reaches around 10 per cent of stroke patients in time to prevent lasting damage. For other patients, there are no other effective drugs that reduce the loss of brain function following a stroke.

17 Feb 2011

Metallic copper surfaces kill bacteria on contact

Metallic copper surfaces kill microbes on contact, decimating their populations, according to a paper in the February 2011 issue of the journal Applied and Environmental Microbiology. They do so literally in minutes, by causing massive membrane damage after about a minute's exposure, says the study's corresponding author, Gregor Grass of the University of Nebraska, Lincoln. This is the first study to demonstrate this mechanism of bacteriocide.

17 Feb 2011

Researchers develop new pneumococcal vaccine through novel discovery approach

Pneumococcus accounts for as much as 11 percent of mortality in young children worldwide. While successful vaccines like Prevnar exist, they are expensive and only work against specific pneumococcal strains, with the risk of becoming less effective as new strains emerge.

17 Feb 2011

ICR, AB SCIEX collaborate to standardize mass spectrometry-based tissue imaging

A key research area for The Institute of Cancer Research is investigating the spread of cancer in the human body in an effort to identify new and effective treatment strategies. To help advance this research, the ICR is collaborating with scientists at AB SCIEX, a global leader in life science analytical technologies, to standardize advanced methods of mass spectrometry-based tissue imaging.

17 Feb 2011

Spirulina Pacifica supplement may improve immune function, anemia in senior citizens

Cyanotech Corporation, world leader in microalgae-based health and nutrition supplements, announced today that researchers at the University of California at Davis have determined that microalgae-based Hawaiian Spirulina Pacifica may improve immune function and ameliorate anemia in persons over 50.

17 Feb 2011

Brain enzyme blocks accumulation of tau proteins, slows down progression of neural degeneration

Increasing puromycin-sensitive aminopeptidase, the most abundant brain peptidase in mammals, slowed the damaging accumulation of tau proteins that are toxic to nerve cells and eventually lead to the neurofibrillary tangles, a major pathological hallmark of Alzheimer's disease and other forms of dementia, according to a study published online in the journal, Human Molecular Genetics.

17 Feb 2011

First evidence of neurotrophic factors improving status of degenerating dopamine neurons in Parkinson's brains

Ceregene, Inc., a biopharmaceutical company, reported today that its scientists and collaborators have published new experimental findings in support of its Parkinson's disease program which appeared as the lead article in the current issue of Movement Disorders. The publication reports the first evidence that gene transfer can provide targeted expression of a neurotrophic factor, i.e., neurturin or NRTN, intended to restore and preserve dying neurons.

17 Feb 2011

Deactivation of CRTC1 protein increases lifespan

Substantial evidence suggests that lifespan is increased if an organism restricts its daily calorie intake, a spartan regime that some say works by just making life seem longer. A team of scientists from the Salk Institute of Biological Studies has discovered a molecular switch flipped by hunger that could not only make longevity more appetizing but identify drug targets for patients with aging-related diseases such as type II diabetes or cancer.

17 Feb 2011

Loss of 'twenty-four' gene makes it harder to wake up

Northwestern University scientists have discovered a new mechanism in the core gears of the circadian clock. They found the loss of a certain gene, dubbed "twenty-four," messes up the rhythm of the common fruit fly's sleep-wake cycle, making it harder for the flies to awaken.

17 Feb 2011

Molecular explanation to higher tendency for autism among males

George Washington University researcher, Dr. Valerie Hu, Professor of Biochemistry and Molecular Biology, and her team at the School of Medicine and Health Sciences, have found that male and female sex hormones regulate expression of an important gene in neuronal cell culture through a mechanism that could explain not only higher levels of testosterone observed in some individuals with autism, but also why males have a higher incidence of autism than females.

17 Feb 2011

Study sheds light on novel functions of certain PCSK enzymes

Recent studies conducted at the Institut de recherches cliniques de Montr-al on a group of PCSK enzymes could have a positive impact on health, from cholesterol to osteoporosis.

17 Feb 2011

Protein News and Research

Further Reading

Cyclacel's CYC065 CDK inhibitor demonstrates potential against breast cancer resistant to trastuzumab

BioMimetic highlights updates on orthopedic and rehabilitation devices during AAOS meeting

Researchers identify normal movement mechanisms of PrPC in brain

Avenir team discovers how Neisseria meningitidis disseminates into bloodstream

Statin drug may help prevent blindness in diabetics

Iris Pharma announces validation of new EIU model of ocular inflammation

AAN honors three researchers with 2011 Potamkin Prize for dementia study

Study: Cigarette smoking linked to mucus overproduction in patients with chronic bronchitis

Positive preliminary data from ongoing PSMA ADC phase 1 study against prostate cancer

Researchers discover substance that reinforces brain's self-healing functions after stroke

Metallic copper surfaces kill bacteria on contact

Researchers develop new pneumococcal vaccine through novel discovery approach

ICR, AB SCIEX collaborate to standardize mass spectrometry-based tissue imaging

Spirulina Pacifica supplement may improve immune function, anemia in senior citizens

Brain enzyme blocks accumulation of tau proteins, slows down progression of neural degeneration

First evidence of neurotrophic factors improving status of degenerating dopamine neurons in Parkinson's brains

Deactivation of CRTC1 protein increases lifespan

Loss of 'twenty-four' gene makes it harder to wake up

Molecular explanation to higher tendency for autism among males

Study sheds light on novel functions of certain PCSK enzymes

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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