Protein Expression News and Research

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HIV-1 Tat expression leads to perturbations in cellular protein expression, research suggests

The cover for issue 54 of Oncotarget features Figure 2, "Comparative proteomic profiling of the peptides/proteins identified from 293T, IL16lamp2b and mExo-Tat samples," by Lu, et al.

4 Oct 2019

Researchers develop 3D tissue models of brain tumors in a brain-mimicking microenvironment

A team of Tufts University-led researchers has developed three-dimensional human tissue culture models of pediatric and adult brain cancers in a brain-mimicking microenvironment, a significant advancement for the study of brain tumor biology and pharmacological response.

4 Oct 2019

Researchers explore remodeling of cardiac tissues post-aortic valve replacement

University of Colorado Boulder engineers and faculty from the Consortium for Fibrosis Research & Translation at the University of Colorado Anschutz Medical Campus have teamed up to develop biomaterial-based "mimics" of heart tissues to measure patients' responses to an aortic valve replacement procedure, offering new insight into the ways that cardiac tissue re-shapes itself post-surgery.

12 Sep 2019

Developing next generation treatment to counteract opioid addiction

There are many moments in the human experience when tragedy elicits not only compassion, but inspiration. When Mike Zhang heard the story of a mother whose son died of an opioid overdose just one month after the teenager's introduction to the drug at a party, the Virginia Tech researcher wanted to help.

11 Sep 2019

Novel technology makes biopsies less invasive and more informative

A team of researchers from the National University of Singapore has developed a novel technology that could sensitively and accurately detect and classify cancer cells, as well as determine the disease aggressiveness from the least invasive biopsies.

10 Sep 2019

Neurobiological pathophysiology of schizophrenia differs based on gender

The neurobiological pathophysiology of schizophrenia differs significantly between males and females, according to a new study.

4 Sep 2019

New model system uses red blood cells to study malaria invasion

Researchers at the University of Bristol and Imperial College London have established a new model system that uses red blood cells grown in the laboratory to study how malaria parasites invade red blood cells.

29 Aug 2019

Sartorius Stedim Biotech announces launch of new services for mammalian cell bank manufacturing

Sartorius Stedim Biotech (SSB), a leading partner of the biopharmaceutical industry, today announced the launch of new services for mammalian cell bank manufacture under GMP conditions.

From Sartorius 13 Aug 2019

Moffitt study uncovers subtypes of squamous cell lung cancer

Lung cancer is the number one cause of cancer-related deaths in the United States, with squamous cell lung cancer (SCC) being one of the common types.

8 Aug 2019

Altered protein and mutated clusters of genes in Alzheimer’s disease

Alzheimer's disease (AD) diagnosis and treatment has been a challenge and this is mainly due to the varying degrees of degeneration and cognitive damage seen in different patients. The researchers from the University of California San Diego School of Medicine for the first time used the transcriptome to assess the proteins made from the genes in patients with AD, that could help in diagnosis.

23 Jul 2019

New quantitative biomarker helps assess quality of corneal cells

Our eyes -- the windows to the soul -- need constant care, and as we age, they sometimes also need significant repair.

23 Jul 2019

BIA Separations selected to support AveXis’ gene therapy pipeline

BIA Separations, a leading biochromatography development and manufacturing company, today announced it is collaborating with AveXis, a Novartis company, to enhance the commercial purification process for its gene therapy pipeline, beginning with Zolgensma (onasemnogene abeparvovec-xioi), the first U.S. Food and Drug Administration-approved gene therapy indicated for the treatment of pediatric patients with spinal muscular atrophy (SMA) who are less than two years of age.

22 Jul 2019

Study sheds light on complex caspase-1-induced cell death mechanisms

Most unnecessary or dangerous cells such as virus-infected cells commit suicide by activating an in-built suicide program.

5 Jul 2019

Study suggests therapeutic solutions for pantothenate kinase-associated neurodegeneration

The scientific research team from the Universidad Pablo de Olavide led by doctor José Antonio Sánchez Alcázar has published a new study in the international magazines Molecular Neorubiology and Neural Regeneration Research.

11 Jun 2019

Roche Diagnostics launches first in vitro diagnostic ROS1 immunohistochemistry assay

Roche Diagnostics today announced the launch of the VENTANA ROS1 Antibody, the first and only in vitro diagnostic ROS1 immunohistochemistry assay. The test detects the presence of ROS1 protein in tissue, and may be useful in identifying ROS1-positive lung cancer cases.

From Roche Sequencing and Life Science 10 Jun 2019

Researchers identify why lymphoma patients may become resistant to specific drug

With more targeted therapies being approved each year for cancer, the development of drug resistance to these agents is a growing concern.

16 May 2019

Regular endurance exercise leads to high Nrf2 nuclear translocation, DNA binding activity

Skeletal muscle mass and function becomes progressively compromised with aging, chronic disease, and physical inactivity.

26 Apr 2019

Six factors associated with invasive breast cancer recurrence after DCIS diagnosis

Six factors were associated with invasive recurrence of breast cancer after a diagnosis of ductal carcinoma in situ (DCIS), according to data from a meta-analysis.

25 Apr 2019

Online atlas created to identify, classify protein signatures present at AML diagnosis

Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis.

17 Apr 2019

Potential new therapeutic approach identified for neuroblastoma tumors

Research led by Michael Lan, PhD, Professor of Pediatrics and Genetics at LSU Health New Orleans School of Medicine, found that a compound named 5'-iodotubercidin (5'-IT) suppresses the growth of neuroblastoma cells and identified a potential new therapeutic approach for the disease.

12 Apr 2019