Protein–Protein Interactions News and Research

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New experimental compound offers hope for patients with non-Hodgkin's lymphoma

Researchers from the Sackler Center at Weill Cornell Medical College have designed a new class of drugs that targets BCL6, a master regulatory protein responsible for causing the most common type of non-Hodgkin's lymphoma.

15 Apr 2010

Researchers report major step forward in effort to understand and engineer protein structure

Researchers in Singapore are reporting this week that they have gleaned key insights into the architecture of a protein that controls iron levels in almost all organisms. Their study culminated in one of the first successful attempts to take apart a complex biological nanostructure and isolate the rules that govern its natural formation.

12 Apr 2010

Evotec, Active Biotech announce collaboration to identify small molecule modulators of priority biological target

Evotec AG today announced that it has entered into a collaboration with Active Biotech AB to identify small molecule modulators of a priority biological target, selected by Active Biotech, involved in immune disorders and cancer.

11 Mar 2010

Boehringer Ingelheim, Priaxon announce collaboration in development of mdm2/p53 inhibitors for cancer

Boehringer Ingelheim and Priaxon entered into a worldwide collaboration to research and develop mdm2/p53 inhibitors for the treatment of cancer. Priaxon is providing its innovative and proprietary small molecule drug discovery expertise which is particularly suited to investigate inhibition of protein-protein interactions. p53 is a human tumor suppressor protein.

18 Jan 2010

Elusive human protein outsmarted

A team of researchers is being recognized for devising a new way to study a human protein that long has evaded close scrutiny by scientists investigating its role in the communication of important genetic messages inside a cell's nucleus to workhorse molecules found elsewhere.

5 Jan 2010

Publication validates company's structure-based approach for addressing undruggable targets

Emerald BioStructures (formerly deCODE biostructures) announced today a publication in the December 27, 2009 advance online issue of Nature Biotechnology, detailing the application of structure-based drug design (SBDD) to engineer new allosteric small molecule modulators of the enzyme phosphodiesterase-4 (PDE4), with reduced side effects.

28 Dec 2009

Microbial Pathogenomics: A collection of reviews and future trends in bacterial pathogenomics

'Microbial Pathogenomics' contains a unique collection of reviews demonstrating how genomics has revolutionized our understanding of virulence, host-adaptation strategies and the evolution of bacterial pathogens. Current technologies - computational tools and functional approaches to genome analysis - are carefully documented and clearly illustrated.

23 Dec 2009

NIH awards $14.6M for Eukaryotic Pathogen Genome Database Resource expansion

Researchers from the University of Pennsylvania and the University of Georgia have been awarded a five-year, $14.6 million contract from the National Institute of Allergy and Infectious Diseases, part of the US National Institutes of Health, to expand and extend work on the Eukaryotic Pathogen Genome Database Resource, http://EuPathDB.org.

11 Dec 2009

Copper sequestering drug tetrathiomolybdate shown to be effective in treating Wilson disease

The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers.

27 Nov 2009

Discovery of 12 proteins associated with pediatric multiple sclerosis

A group of 12 proteins associated with pediatric multiple sclerosis (MS) have been discovered for the first time by a team of neurology and pathology researchers at Stony Brook University Medical Center.

22 Apr 2009

Scientists discover key molecules that inhibit viral production

The research, led by Professor Donny Strosberg of Scripps Florida, was published on March 4, 2009, in the Journal of General Virology's advance, online edition, Papers in Press.

11 Mar 2009

New tools that spotlight individual cellular molecules are transforming biomedical research

Remarkable new tools that spotlight individual cellular molecules are transforming biomedical research.

27 Jan 2009

FORMA Therapeutics to collaborate with Novartis on inhibitors

FORMA Therapeutics has announced that it has entered into a license and option agreement through the Novartis Option Fund.

12 Jan 2009

Studies offer guide as protein interaction mapping comes of age

During the past 20 years, researchers have identified thousands of cell protein interactions, with the ultimate goal of inventorying all that occur within cells of various organisms - a comprehensive catalogue known as the interactome.

6 Jan 2009

Discovery of 'on switch' for cell death signaling mechanism

Scientists at Burnham Institute for Medical Research (Burnham) have determined the structure of the interactions between proteins that form the heart of the death inducing signaling complex (DISC), which is responsible for triggering apoptosis (programmed cell death).

5 Jan 2009

Discovery of small molecule that disrupts Ewing's sarcoma oncogene

Researchers at Georgetown University Medical Center have found a small molecule they say can block the action of the oncogene that causes Ewing's sarcoma, a rare cancer found in children and young adults.

13 Apr 2008

New large-scale method reveals drug targets

Wellcome Trust Sanger Institute scientists have developed a new large-scale method to identify the interactions between proteins that are a major target for therapeutic intervention.

26 Feb 2008

Researchers report protein interactions of MAP kinase signaling pathway

The Stowers Institute's Rong Li Lab, in collaboration with the Institute's Imaging Center, has achieved a quantitative in vivo measurement of the dynamic protein-protein interactions in the mitogen-activated protein (MAP) kinase cascade signaling pathway, which is critical to growth and differentiation decisions in all eukaryotic cells.

14 Dec 2007

Researchers shine the light of venus to learn how the herpes virus invades cells

University of Pennsylvania researchers have uncovered an important step in how herpes simplex virus, HSV-1, uses cooperating proteins found on its outer coat to gain entry into healthy cells and infect them.