Pulmonary Fibrosis News and Research

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Men with hematopoietic mosaic loss of Y chromosome have worse prognosis for heart failure

research group led by Dr. Soichi Sano, a specially appointed lecturer in the Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka Metropolitan University, revealed that men with hematopoietic mosaic loss of Y chromosome (mLOY) — meaning men with an increase, in the blood, of cells that have lost the male sex chromosome — have a worse prognosis for heart failure due to fibrosis progression in the heart.

15 Jul 2022

Y chromosome loss in men can lead to deadly heart failure, research shows

The loss of the male sex chromosome as many men age causes the heart muscle to scar and can lead to deadly heart failure, new research from the University of Virginia School of Medicine shows.

14 Jul 2022

Experimental model reveals possible causes and treatments for long-COVID

In a recent study published in the journal Science Translational Medicine, researchers characterized long-term pulmonary consequences of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) mouse-adapted strain (MA10) infection in BALB/c laboratory mice.

11 Jul 2022

Novel inhalable COVID-19 vaccine

A recent study published in the Nature Biomedical Engineering journal illustrated a novel inhalable SARS-CoV-2 vaccine candidate centered on exosomes (Exos) coupled with recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD).

5 Jul 2022

Study shows long COVID remodeling of T cell dynamics is dependent on SARS-CoV-2 severity

A new study found that the post-COVID-19 functional remodeling of T cells occurs in two steps and confers different convalescent immune states, six months after SARS-CoV-2 infection.

30 Jun 2022

Pulmonary and primary care experts aim to reduce the time to diagnose interstitial lung diseases

The American College of Chest Physicians (CHEST) and Three Lakes Foundation are announcing a steering committee of experts in the fields of pulmonary medicine and primary care medicine to lead an initiative called Bridging Specialties™: Timely Diagnosis for ILD Patients.

9 Jun 2022

Insilico Medicine plans to launch a fully automated AI-driven robotics lab for drug discovery

Insilico Medicine's end-to-end AI-driven drug discovery platform, Pharma.AI, draws its strength from the quality and quantity of its data. As Insilico scientific advisory board member and Nobel Prize laureate in chemistry Dr. Michael Levitt has said, Insilico's platform capitalizes on the ability of artificial intelligence to take vast amounts of data from many different components and find patterns and make predictions that can point the way to new life-saving medications.

9 Jun 2022

Zinc may reverse lung damage, improve survival for patients with idiopathic pulmonary fibrosis

Investigators from the Women's Guild Lung Institute at Cedars-Sinai have discovered that zinc, a common mineral, may reverse lung damage and improve survival for patients with a deadly age-related condition known as idiopathic pulmonary fibrosis (IPF).

8 Jun 2022

Scientists determine trajectory and pathophysiology of post-COVID-19 syndrome

A new study utilizes multisystem imaging, along with biomarker analysis, to better understand the pathogenesis of COVID-19.

30 May 2022

Researchers propose DLPE method to extract interpretable and predictive subvisual features from CT scans of COVID-19 inpatients and survivors

Researchers assessed deep learning workflows involved in CT scans of COVID-19.

25 May 2022

Largest study to date on long COVID identifies a broad list of diagnoses

Researchers characterize post-acute sequelae of SARS-CoV-2 infection.

25 May 2022

Researchers use mouse model to explore correlation of impaired interferon-mediated immune response with severe COVID-19

Researchers developed a highly pathogenic mouse-adapted SARS-CoV-2 strain to model mild, moderate, or COVID-19.

26 Apr 2022

CHEST and Three Lakes Foundation collaborate to reduce delays in diagnosing Interstitial Lung Diseases

Three Lakes Foundation and the American College of Chest Physicians recently announced their collaboration on a multiphase educational initiative aiming to reduce the time it takes to diagnose patients with Interstitial Lung Diseases (ILD).

19 Apr 2022

Lung abnormalities may remain detectable long after COVID-19 pneumonia

Some people recovering from COVID-19 pneumonia have CT evidence of damage to their lungs that persists a full year after the onset of symptoms, according to a new study published in the journal Radiology.

30 Mar 2022

Biomarkers to identify SARS-CoV-2 patients requiring invasive mechanical ventilation

Researchers evaluated biomarkers that could help identify COVID-19 patients needing invasive mechanical ventilation.

17 Mar 2022

Orally-active senolytics can boost a key beneficial protein in mice and humans

Mayo Clinic researchers say senolytic drugs can boost a key protein in the body that protects older people against aspects of aging and a range of diseases.

15 Mar 2022

How does COVID-19 affect patients with idiopathic pulmonary fibrosis?

A new study discusses the outcomes of idiopathic pulmonary fibrosis patients with confirmed SARS-CoV-2 infection.

6 Mar 2022

Phase I clinical trial evaluates AI-discovered first anti-fibrotic small molecule inhibitor

Insilico Medicine, an end-to-end artificial intelligence (AI)-driven drug discovery company, today announced that it has dosed multiple healthy volunteers in Phase I clinical trial evaluating ISM001-055, the first anti-fibrotic small molecule inhibitor generated by Insilico's AI-powered drug discovery platform for idiopathic pulmonary fibrosis (IPF).

24 Feb 2022

Cardiopulmonary limitations six months after surviving COVID-19

A recent prospective cohort study assessed the cardiopulmonary effects in patients six months after COVID-19 infection.

23 Feb 2022

Mouse-adapted virus model to study persistent COVID induced lung disease

Researchers develop a mouse model to identify early biomarkers and test countermeasures needed to detect and prevent PASC.

21 Feb 2022