RNA Sequencing News and Research

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NEI researchers link age-related DNA modifications to susceptibility to eye disease

Researchers profiling epigenomic changes in mouse photoreceptors suggest that age-related eye diseases may be linked to gene expression.

21 Apr 2020

First detailed map of transcriptome and epitranscriptome for novel coronavirus (SARS-CoV-2)

A team of researchers has come out with the first detailed map of the transcriptome and epitranscriptome of the virulent SARS-CoV-2 that causes COVID-19 disease, the illness that has become a pandemic ravaging both developed and less developed countries of the world. The study, published in the journal Cell in April 2020, may assist in the development of new vaccines and therapeutics.

12 Apr 2020

Researchers develop online resource to refine results from RNA sequencing

DNA sequencing is becoming a more commonplace method for detecting diseases and improving precision medicine.

8 Apr 2020

International group determines best method for sequencing single-cell RNA

To ensure that single-cell RNA sequencing makes use of the best methods, an international group has benchmarked 13 methods.

6 Apr 2020

Scientists unravel a new mechanism that triggers cell death and inflammation

Z-form nucleic acids are double-stranded DNA and RNA molecules with an unusual left-handed double helix structure, as opposed to the classical right-handed Watson-Crick double helix. Z-nucleic acids were discovered more than 40 years ago, but their biological function has remained poorly understood.

31 Mar 2020

CRG launches new database to advance international research efforts on COVID-19

Researchers from the Centre for Genomic Regulation have launched a new database to advance the international research efforts studying COVID-19.

27 Mar 2020

3D chromatin landscapes in T cell acute lymphoblastic leukemia important beyond DNA code changes

Children with aggressive blood cancers have differences -- not just in the DNA code of their blood cells -- but also in the heavily twisted protein superstructure that controls access to genes.

23 Mar 2020

Changes in 3D genetic structure equally important as DNA code mutations in childhood leukemia

A study found that children with aggressive blood cancers have different superstructures of the proteins that control gene access.

23 Mar 2020

New UCI-led study reveals how skin cells prepare to heal wounds

Scientists have revealed how skin cells prepare to heal, potentially leading to better understanding of healing within diabetes.

20 Mar 2020

Study reveals major changes that occur in mammalian skin cells during wound healing

A team of University of California, Irvine researchers have published the first comprehensive overview of the major changes that occur in mammalian skin cells as they prepare to heal wounds.

19 Mar 2020

Researchers establish a gene expression profile associated with cachexia in cancer patients

It is estimated that as many as 80% of advanced-stage cancer patients may develop cachexia, a potentially fatal metabolic syndrome characterized by extreme weight loss and muscle wasting, but scientists do not yet fully understand why it is more frequently associated with certain kinds of tumor than others, or why not all cancer patients develop it.

3 Mar 2020

Researchers map the cellular diversity of entire salivary gland tumors

What goes on inside and between individual cells during the very earliest stages of tumor development? Single cell sequencing technologies and a mouse model have enabled researchers to comprehensively map the cellular diversity of whole salivary gland tumors and trace the path of cancer stem cells.

20 Feb 2020

New Endothelial Cell Atlas can be used to improve treatments for many diseases

New surprising knowledge on endothelial cells in a dozen different murine tissues is now available in an open access, user-friendly, database for professionals.

20 Feb 2020

Targeted combinatorial drug treatment restores beta cell function in mice

The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main reason for the development of diabetes.

20 Feb 2020

Study reveals how overexposure to fluoride causes defects in tooth enamel

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel- a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises.

18 Feb 2020

Intratumoral heterogeneity linked to chemotherapy resistance in small-cell lung cancer

Small cell lung cancer accounts for 14% of all lung cancers and is often rapidly resistant to chemotherapy, resulting in poor clinical outcomes.

17 Feb 2020

New technique may yield insights on the immune response to intestinal parasite infections

A new technique may help scientists study the body's immune response to intestinal parasite infections one gut cell at a time, according to a study published today in eLife.

11 Feb 2020

Developmental shape-shifting is key to cancer's ability to spread and evade immune defenses

Just as people tend to become stuck in their ways as they grow older so too do cells. Neurons in the brain don't one day decide to become heart cells; skin cells repair wounds with skin cells rather than kidney cells.

11 Feb 2020

Heart muscle cells of zebrafish change their metabolism during heart regeneration

Researchers from the group of Jeroen Bakkers at the Hubrecht Institute have found that the muscle cells in the heart of zebrafish change their metabolism, the way in which they generate energy, during heart regeneration.

5 Feb 2020

Yale researchers take important step toward curbing the threat posed by tsetse fly

When an infected tsetse fly bites humans or other mammals to feed on their blood, microscopic parasites (African trypanosomes) in the fly's saliva are transferred. The unfortunate recipient of the bite, once infected, often faces severe health consequences, even death.

3 Feb 2020

RNA Sequencing News and Research

NEI researchers link age-related DNA modifications to susceptibility to eye disease

First detailed map of transcriptome and epitranscriptome for novel coronavirus (SARS-CoV-2)

Researchers develop online resource to refine results from RNA sequencing

International group determines best method for sequencing single-cell RNA

Scientists unravel a new mechanism that triggers cell death and inflammation

CRG launches new database to advance international research efforts on COVID-19

3D chromatin landscapes in T cell acute lymphoblastic leukemia important beyond DNA code changes

Changes in 3D genetic structure equally important as DNA code mutations in childhood leukemia

New UCI-led study reveals how skin cells prepare to heal wounds

Study reveals major changes that occur in mammalian skin cells during wound healing

Researchers establish a gene expression profile associated with cachexia in cancer patients

Researchers map the cellular diversity of entire salivary gland tumors

New Endothelial Cell Atlas can be used to improve treatments for many diseases

Targeted combinatorial drug treatment restores beta cell function in mice

Study reveals how overexposure to fluoride causes defects in tooth enamel

Intratumoral heterogeneity linked to chemotherapy resistance in small-cell lung cancer

New technique may yield insights on the immune response to intestinal parasite infections

Developmental shape-shifting is key to cancer's ability to spread and evade immune defenses

Heart muscle cells of zebrafish change their metabolism during heart regeneration

Yale researchers take important step toward curbing the threat posed by tsetse fly

Sequencing & Genomics: Elevating Science and Healthcare eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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