RNA Sequencing News and Research

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Using math equations to detect and forecast liver cancer risk

The use of mathematical modeling in the study of biological systems has become a challenging and rewarding field of research as it yields many unknown pieces of information. A new study published online on December 16, 2019, in the journal Proceedings of the National Academy of Science (PNAS).

17 Dec 2019

Molecular subtyping of bladder tumors outperformed by standard pathology tests

While trying to develop a comparatively easy, inexpensive way to give physicians and their patients with bladder cancer a better idea of likely outcome and best treatment options, scientists found that sophisticated new subtyping techniques designed to do this provide no better information than long-standing pathology tests.

14 Dec 2019

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Cancer immunology drugs, which harness the body's immune system to better attack cancer cells, have significantly changed the face of cancer treatment. People with aggressive cancers are now living longer, healthier lives. Unfortunately, cancer immunology therapy only works in a subset of patients.

9 Dec 2019

Researchers validate RNA sequencing methods using crab's nervous system model

"Being crabby" might have a whole new meaning.

6 Dec 2019

Using genomics to identify promising novel treatment for lymphatic filariasis

Using innovative RNA sequencing techniques, researchers at the University of Maryland School of Medicine Institute for Genome Sciences identified a promising novel treatment for lymphatic filariasis, a disabling parasitic disease that is difficult to treat.

3 Dec 2019

Scientists discover new molecular drivers of Parkinson's disease

Scientists at the Icahn School of Medicine at Mount Sinai have uncovered new molecular drivers of Parkinson's disease using a sophisticated statistical technique called multiscale gene network analysis.

20 Nov 2019

MIT researchers develop method to isolate T cells primed for certain allergies or infections

When your immune system is exposed to a vaccine, an allergen, or an infectious microbe, subsets of T cells that can recognize a foreign intruder leap into action.

19 Nov 2019

Vaping wrecks immune cell function, increases infection risk

A new study published in the Journal of the American College of Cardiology shows that e-cigarettes have toxic effects on neutrophils function, making them a threat to human health by increasing the likelihood of infection with Gram-negative bacteria.

17 Nov 2019

Yale-led study provides roadmap to discover new treatment for idiopathic pulmonary fibrosis

A Yale-led collaborative study boosts scientific understanding of how the lung disease idiopathic pulmonary fibrosis (IPF) progresses, providing a roadmap for researchers to discover new treatment targets for the disease.

15 Nov 2019

Collaborative study shows sex-specific processes in schizophrenia and bipolar disorder

Recent studies have found a high genetic similarity of the psychiatric diseases schizophrenia and bipolar disorder, whose disease-specific changes in brain cells show an overlap of more than 70 percent.

12 Nov 2019

New method for identifying 'biomarkers' of drug response in triple-negative breast cancer cell lines

Triple-negative breast cancer is an aggressive cancer, one that's likely to recur and to metastasize.

10 Nov 2019

Human heart cells show remarkable adaptability during and after spaceflight

Heart muscle cells derived from stem cells show remarkable adaptability to their environment during and after spaceflight, according to a study publishing November 7 in the journal Stem Cell Reports.

8 Nov 2019

Oxygen-deprived tumor cells have survival advantage that promotes metastasis

Using cells from human breast cancers and mouse breast cancer models, researchers at the Johns Hopkins Kimmel Cancer Center say they have significant new evidence that tumor cells exposed to low-oxygen conditions have an advantage when it comes to invading and surviving in the bloodstream.

7 Nov 2019

Risky strategy allows malaria parasite to quickly respond to unpredictable changes

The parasite that causes malaria expresses genes that code for the proteins it will need in later life stages, using two separate schemes to prevent these proteins from actually being made until they are needed, according to new research.

31 Oct 2019

Scientists modify a toxic protein to create a biosensor

Researchers have shown that the pore-forming toxin (PFT), aerolysin, could be used as a biosensor in the sequencing of DNA and proteins.

30 Oct 2019

Dynamic molecular signaling waves control embryonic fates

Timing is everything for young cells waiting to determine their identities.

29 Oct 2019

Ultraviolet B light is good for the gut microbiome

A small study published in the journal Frontiers in Immunologyon October 24, 2019, shows that exposure to ultraviolet B (UVB) light, which is commonly achieved through sunlight exposure, can trigger specific beneficial changes in the gut microbiome, which are dependent on the preceding serum levels of vitamin D.

24 Oct 2019

Unhealthy gut microbiome reduces brain synaptic pruning, impairs learning

A new study by Weill Cornell Medicine and Cornell University has come up with more explanations of how gut microbes communicate with the brain neurons. The study, published in the journal Nature on October 23, 2019, examined the brains of mouse models and found that when the gut microbiome is significantly reduced, there are changes in gene expression in the brain’s microglial cells.

24 Oct 2019

Study shows link between high-fat diet and earlier appearance of Alzheimer's markers in the brain

Once it begins, Alzheimer's disease progresses systematically and aggressively, attacking victims on multiple fronts. But scientists studying the disease operate the same way - like Kent State University's own Gemma Casadesus Smith, Ph.D.

17 Oct 2019

Cell discovery could help fight against liver disease

Scientists have identified new sub-types of cells that, when they interact, accelerate the scarring process in diseased livers.

9 Oct 2019