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Emory’s Yerkes Research Center receives $9.5M grant to establish research center to study oxytocin

The Yerkes National Primate Research Center, Emory University, has received a five-year, $9.5 million grant from the National Institute of Mental Health (NIMH) to establish a Silvio O. Conte Center in Neuroscience Research to study oxytocin, a brain chemical known for forming bonds between mother and baby.

13 Aug 2013

Study finds that higher-frequency electric current stimulation of the spinal cord reduces pain faster

An animal study in the August issue of Anesthesiology suggests that higher-frequency electric current stimulation of the spinal cord reduced pain quicker and better reached nerves not affected by traditionally used frequencies. A higher frequency and intensity controlled pain faster and more effectively, the study found.

25 Jul 2013

Researchers hope voice therapy in aging humans may help improve quality of life

A new study shows that the vocal training of older rats reduces some of the voice problems related to their aging, such as the loss of vocal intensity that accompanies changes in the muscles of the larynx. This is an animal model of a vocal pathology that many humans face as they age.

25 Jun 2013

Diachisis can occur during subacute phase of ischemic stroke, find USF researchers

While the effects of acute stroke have been widely studied, brain damage during the subacute phase of stroke has been a neglected area of research. Now, a new study by the University of South Florida reports that within a week of a stroke caused by a blood clot in one side of the brain, the opposite side of the brain shows signs of microvascular injury.

21 May 2013

Research reveals that molecular madness goes on in the brain after blast exposure

A multicenter study led by scientists at the University of Pittsburgh School of Medicine shows that mild traumatic brain injury after blast exposure produces inflammation, oxidative stress and gene activation patterns akin to disorders of memory processing such as Alzheimer's disease.

25 Apr 2013

Study: Intake of carbohydrate-enriched foods after birth predisposes child to obesity later in life

Consumption of foods high in carbohydrates immediately after birth programs individuals for lifelong increased weight gain and obesity, a University at Buffalo animal study has found, even if caloric intake is restricted in adulthood for a period of time.

20 Mar 2013

Thyroid hormone may help reduce heart damage in humans with cardiac diseases

Thyroid hormone treatment administered to rats at the time of a heart attack (myocardial infarction) led to significant reduction in the loss of heart muscle cells and improvement in heart function, according to a study published by a team of researchers led by A. Martin Gerdes and Yue-Feng Chen from New York Institute of Technology College of Osteopathic Medicine.

1 Mar 2013

Brain cooling after severe head injury may prevent epileptic seizures

In the weeks, months and years after a severe head injury, patients often experience epileptic seizures that are difficult to control. A new study in rats suggests that gently cooling the brain after injury may prevent these seizures.

22 Feb 2013

Imatinib can relieve and slow down progression of multiple sclerosis

A drug that is currently used for cancer can relieve and slow down the progression of the autoimmune disease multiple sclerosis (MS) in rats, according to a new study published in PLOS ONE.

21 Feb 2013

Study finds reason why patients with chronic pain often suffer from impaired short -term memory

A group of Portuguese researchers from IBMC and FMUP at the University of Porto has found the reason why patients with chronic pain often suffer from impaired short -term memory.

9 Feb 2013

New rat model simulates traumatic or surgical muscle tissue loss in humans

Penetrating soft tissue injuries that may be caused by bullet wounds or motor vehicle accidents, or exposure to explosive devices in military settings, can cause muscle loss resulting in functional disability and cosmetic deformity. Efforts underway to develop tissue engineering solutions to repair and replace damaged and lost muscle will benefit greatly from the availability of robust animal models to test these innovative therapeutic strategies.

4 Jan 2013

CYP2J2 implicated in preeclampsia

Study findings suggest that uteroplacental cytochrome P450 subfamily 2J polypeptide 2 overexpression contributes to preeclampsia.

11 Dec 2012

CYP2J2 implicated in preeclampsia

Study findings suggest that uteroplacental cytochrome P450 subfamily 2J polypeptide 2 overexpression contributes to preeclampsia.

10 Dec 2012

Perimenopausal lifestyle modifications could reduce risk of breast cancer in obese woman

Obese women might be able to eliminate their increased risk for postmenopausal breast cancer by taking measures during perimenopause to prevent weight gain and to therapeutically control the metabolic effects of their obesity, according to the results of a preclinical study published in Cancer Research, a journal of the American Association for Cancer Research.

10 Dec 2012

Western University research could lead to better treatments for PTSD and drug addiction

New research from Western University could lead to better treatments for Post-Traumatic Stress Disorder (PTSD) and drug addiction by effectively blocking memories. The research performed by Nicole Lauzon, a PhD candidate in the laboratory of Steven Laviolette at Western's Schulich School of Medicine & Dentistry has revealed a common mechanism in a region of the brain called the pre-limbic cortex, can control the recall of memories linked to both aversive, traumatic experiences associated with PTSD and rewarding memories linked to drug addiction.

6 Dec 2012

Innovative stem cell technique for heart tissue revealed

Researchers have found that stem cell cultures infused with growth factors could be used to repair damaged heart tissue without the threat of patient rejection.

3 Dec 2012

Epizyme to present data from DOT1L and EZH2 inhibitor programs at 54th ASH annual meeting

Epizyme, Inc., a biopharmaceutical company leading the creation of personalized therapeutics to treat patients with genetically defined cancers, today announced the presentation of data evaluating the preclinical safety and efficacy of two of the Company's novel, potent and selective small molecule inhibitors. These inhibitors individually target DOT1L and EZH2, members of a class of epigenic enzymes called histone methyltransferases (HMTs).

30 Nov 2012

Orbitofrontal cortex responsible for decisions made on spur of the moment

An area of the brain called the orbitofrontal cortex is responsible for decisions made on the spur of the moment, but not those made based on prior experience or habit, according to a new basic science study from substance abuse researchers at the University of Maryland School of Medicine and the National Institute on Drug Abuse (NIDA). Scientists had previously believed that the area of the brain was responsible for both types of behavior and decision-making.

27 Nov 2012

New approach could help orthopaedic surgeons better deal with battlefield injuries

Bones are resilient and heal well after most fractures. But in cases of traumatic injury, in which big pieces of bone are missing, healing is much more difficult, if not impossible. These so-called "large segmental defects" are a major clinical problem, and orthopaedic surgeons struggle to treat them, especially among the military in places like Afghanistan.

22 Nov 2012

Hsp104 protein switches mechanism to break up amyloid versus disordered clumps

Several fatal brain disorders, including Parkinson's disease, are connected by the misfolding of specific proteins into disordered clumps and stable, insoluble fibrils called amyloid. Amyloid fibrils are hard to break up due to their stable, ordered structure. For example, α-synuclein forms amyloid fibrils that accumulate in Lewy Bodies in Parkinson's disease. By contrast, protein clumps that accumulate in response to environmental stress, such as heat shock, possess a less stable, disordered architecture.

20 Nov 2012

Rat Model News and Research

Emory’s Yerkes Research Center receives $9.5M grant to establish research center to study oxytocin

Study finds that higher-frequency electric current stimulation of the spinal cord reduces pain faster

Researchers hope voice therapy in aging humans may help improve quality of life

Diachisis can occur during subacute phase of ischemic stroke, find USF researchers

Research reveals that molecular madness goes on in the brain after blast exposure

Study: Intake of carbohydrate-enriched foods after birth predisposes child to obesity later in life

Thyroid hormone may help reduce heart damage in humans with cardiac diseases

Brain cooling after severe head injury may prevent epileptic seizures

Imatinib can relieve and slow down progression of multiple sclerosis

Study finds reason why patients with chronic pain often suffer from impaired short -term memory

New rat model simulates traumatic or surgical muscle tissue loss in humans

CYP2J2 implicated in preeclampsia

CYP2J2 implicated in preeclampsia

Perimenopausal lifestyle modifications could reduce risk of breast cancer in obese woman

Western University research could lead to better treatments for PTSD and drug addiction

Innovative stem cell technique for heart tissue revealed

Epizyme to present data from DOT1L and EZH2 inhibitor programs at 54th ASH annual meeting

Orbitofrontal cortex responsible for decisions made on spur of the moment

New approach could help orthopaedic surgeons better deal with battlefield injuries

Hsp104 protein switches mechanism to break up amyloid versus disordered clumps

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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