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Agendia data reveals impact of MammaPrint on adjuvant treatment decisions in breast cancer patients

Agendia, Inc., a world leader in personalized medicine and molecular cancer diagnostics, has presented new prospective data demonstrating the strong impact of its 70-Gene Breast Cancer Recurrence assay, MammaPrint, and the corresponding 80-Gene Molecular Subtyping Assay BluePrint, in clinical decision-making for patients with early-stage breast cancer in Germany.

22 Dec 2016

Oncotype DX test can help guide treatment decisions and enable personalized care before breast cancer surgery

New data presented at the 2016 San Antonio Breast Cancer Symposium (SABCS) demonstrate that analyzing tumor biology with the Oncotype DX test can identify patients unlikely to benefit from chemotherapy prior to breast cancer surgery (neoadjuvant setting) and guide treatment decisions without compromising outcomes.

22 Dec 2016

New research offers valuable insight for developing more effective drugs to treat IBD

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestine that includes Crohn's disease and ulcerative colitis.

22 Dec 2016

UNC scientists develop new tool to study G-protein signaling

Scientists from the UNC School of Medicine have developed a new tool for studying a key process in cells called G-protein signaling, which plays a central role in the normal functioning of cells and can go awry to cause severe disease, including cancers.

22 Dec 2016

Scientists discover link between Huntington's disease and dysfunction of subthalamic nucleus

Northwestern Medicine scientists identified a link between Huntington's disease and dysfunction of the subthalamic nucleus, a component of the basal ganglia, a group of brain structures critical for movement and impulse control.

21 Dec 2016

Music may regulate mood, emotional responses at behavioral and neuronal level

Sounds, such as music and noise, are capable of reliably affecting individuals' moods and emotions, possibly by regulating brain dopamine, a neurotransmitter strongly involved in emotional behavior and mood regulation.

21 Dec 2016

RAGE regulates key signaling pathway that promotes acute and chronic inflammation

Researchers have shown that Receptor for Advanced Glycation End Products helps to regulate a key signaling pathway known to promote both acute and chronic inflammation.

21 Dec 2016

Researcher develops new method to accurately identify elusive molecules

Among the most important molecules in the living world are sugars or carbohydrates, which play a vital role in life processes. Sugars provide the main source of fuel for the body, protect muscles from damage and contribute to the immune response.

21 Dec 2016

Optical fibers can identify and control neuroreceptors to rapidly inhibit chronic pain

Pain serves as a valuable warning signal, but when it becomes chronic, pain should be considered as a real disease.

21 Dec 2016

UCLA study shows how the brain initiates repair by generating replacement cells after stroke

UCLA researchers have shown that the brain can be repaired — and brain function can be recovered — after a stroke in animals.

21 Dec 2016

Scientists identify potential drug treatment in fight against Alzheimer’s disease

An international team of scientists has announced a new advance in the fight against Alzheimer’s disease by identifying a new drug target for not only improving symptoms of brain degeneration – but also to extend the life-span of the terminally ill mice.

21 Dec 2016

New study reveals IRBIT's role in facilitating apoptosis

Billions of cells in our bodies die every day in an important process called apoptosis. Now, researchers at the RIKEN Brain Science Institute have mapped out a sequence of events that are necessary for apoptosis to occur properly.

21 Dec 2016

Hormone receptor could be potential biomarker for gastric cancer, research shows

Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, the Veterans Affairs Medical Center in Miami, and Shantou University Medical College in China, have shown that the hormone receptor GHRH-R could be a potential biomarker for gastric cancer, enabling earlier diagnoses and better staging.

21 Dec 2016

Active ingredient of pungent substances slows growth of breast cancer cells

Capsaicin, an active ingredient of pungent substances such as chilli or pepper, inhibits the growth of breast cancer cells.

20 Dec 2016

Chromatrap® ensures best quality chromatin in ChIP assays

Chromatrap® offers an optimised unique buffer chemistry that provides the leading solution for the isolation of high quality and high yield chromatin. The success of any ChIP assay is dependent upon the quality of your chromatin.

From Chromatrap® - Porvair Sciences Ltd 20 Dec 2016

Replacing missing gut bacteria could help treat children with rare autoimmune disease

Defects in the body's regulatory T cells (T reg cells) cause inflammation and autoimmune disease by altering the type of bacteria living in the gut, researchers from The University of Texas Health Science Center at Houston have discovered.

19 Dec 2016

Combined endocrine and targeted therapy could be effective in treating Asian breast cancer patients

Ribociclib significantly improves progression-free survival in Asian women with advanced breast cancer, according to a sub-analysis of the MONALEESA-2 trial presented at the ESMO Asia 2016 Congress in Singapore.

17 Dec 2016

Overexpression of nerve growth factor drives gastric tumorigenesis in mice

Gastric tumors are started by specialized cells in the stomach that signal nerves to make more acetylcholine, according to a study in mice.

16 Dec 2016

Researchers pinpoint mechanism underlying astrocyte-mediated recovery of brain tissue after injury

A Kobe University research team has pinpointed the mechanism underlying astrocyte-mediated restoration of brain tissue after an injury. This could lead to new treatments that encourage regeneration by limiting damage to neurons incurred by reduced blood supply or trauma.

15 Dec 2016

Protective effect of ER-beta more pronounced in breast cancer patients who undergo chemotherapy

It is known from previous research that the ER-beta estrogen receptor often has a protective effect. A new study from Lund University in Sweden has found that this effect is more pronounced in patients that undergo chemotherapy.

15 Dec 2016

Receptor News and Research

Agendia data reveals impact of MammaPrint on adjuvant treatment decisions in breast cancer patients

Oncotype DX test can help guide treatment decisions and enable personalized care before breast cancer surgery

New research offers valuable insight for developing more effective drugs to treat IBD

UNC scientists develop new tool to study G-protein signaling

Scientists discover link between Huntington's disease and dysfunction of subthalamic nucleus

Music may regulate mood, emotional responses at behavioral and neuronal level

RAGE regulates key signaling pathway that promotes acute and chronic inflammation

Researcher develops new method to accurately identify elusive molecules

Optical fibers can identify and control neuroreceptors to rapidly inhibit chronic pain

UCLA study shows how the brain initiates repair by generating replacement cells after stroke

Scientists identify potential drug treatment in fight against Alzheimer’s disease

New study reveals IRBIT's role in facilitating apoptosis

Hormone receptor could be potential biomarker for gastric cancer, research shows

Active ingredient of pungent substances slows growth of breast cancer cells

Chromatrap® ensures best quality chromatin in ChIP assays

Replacing missing gut bacteria could help treat children with rare autoimmune disease

Combined endocrine and targeted therapy could be effective in treating Asian breast cancer patients

Overexpression of nerve growth factor drives gastric tumorigenesis in mice

Researchers pinpoint mechanism underlying astrocyte-mediated recovery of brain tissue after injury

Protective effect of ER-beta more pronounced in breast cancer patients who undergo chemotherapy

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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