Receptor News and Research

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Combination treatment with CDK4/6 inhibitor improves progression-free survival in HR+ breast cancer patients

The addition of the CDK4/6 inhibitor ribociclib to letrozole therapy significantly improves progression-free survival in postmenopausal women with hormone receptor-positive advanced breast cancer, researchers reported today at the ESMO 2016 Congress in Copenhagen.

8 Oct 2016

Study of pan-FGFR inhibitor uses mRNA in tumours to identify responders

The first-in-human dose escalation study of the pan-FGFR (fibroblast growth factor receptor) inhibitor BAY 1163877 in patients with treatment-refractory locally advanced or metastatic solid tumours were reported today at the ESMO 2016 Congress in Copenhagen.

8 Oct 2016

Research reveals role of endoglin in shaping blood and cardiac cell fate during early development

New research from the University of Minnesota reveals endoglin as a critical factor in determining the fate of early undifferentiated cells during development.

7 Oct 2016

Researchers explain why explain why some tumors recur after immunotherapy

Immunotherapy is a new and highly promising form of treatment for cancer. In many patients, however, tumors recur after immunotherapy.

7 Oct 2016

No added benefit proven for pulmonary arterial hypertension drug, IQWiG finds

Selexipag is approved for long-term treatment of pulmonary arterial hypertension (PAH) in adults with moderate to severe symptoms.

7 Oct 2016

TUM scientists shed new light on metastases in the liver at early stage of pancreatic cancer

Pancreatic cancer is an exceptionally aggressive type of cancer. Frequently, metastases already start to grow in other organs, particularly often in the liver, before the original tumor was even detected.

7 Oct 2016

Study finds neoadjuvant immunotherapy safe, viable for early lung cancer patients before surgery

Neoadjuvant immunotherapy with the PD-1 inhibitor nivolumab is safe and feasible prior to surgery for early lung cancer, researchers reported at the ESMO 2016 Congress in Copenhagen.

7 Oct 2016

BUSM researchers identify new therapeutic target for treating compulsive binge eating

A new therapeutic target for the treatment of compulsive binge eating has been identified by researchers at Boston University School of Medicine.

6 Oct 2016

Researchers identify new strategy to selectively sensitize cancer cells to radiation therapy

Many types of cancer become drug resistant, making them difficult to treat. Researchers with University of California San Diego School of Medicine and Moores Cancer Center have identified a strategy to selectively sensitize certain cancer cells to radiation therapy that may improve tumor control and reduce treatment-related side effects.

5 Oct 2016

Fruit flies shed light on how insulin signaling processes may be altered by diabetes in humans

Fruit flies may be small, but the genetic secrets they can unlock for humans are mighty.

4 Oct 2016

Can vitamin D reduce asthma attacks? An interview with Professor Adrian Martineau

In the past vitamin D was just thought to be important in regulating calcium homeostasis and bone health as vitamin D deficiency is best known for causing rickets in children and osteomalacia in adults.

4 Oct 2016

Blocking production of key receptor may reduce effects of cigarette smoke toxicity, study finds

A Duke University-led study shows how exposure to the particulate matter from cigarette smoke may affect early development in zebrafish embryos and increases the risk of neurological disorders and physical deformities.

4 Oct 2016

Antibody protection may help control infection caused by TB bacteria

A study led by investigators from the Ragon Institute of MGH, MIT and Harvard finds evidence that antibody protection may help control infection with the bacteria that causes tuberculosis (TB).

4 Oct 2016

Inhibiting single protein could help restore sensitivity to common treatment for breast cancer

A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found, in animal models of human breast cancer, that inhibiting a single protein restores sensitivity to tamoxifen, a commonly used drug for treatment of some breast cancers.

3 Oct 2016

New study reveals CAR T cells can function as micro-pharmacies for precise therapeutic delivery

There has been much recent excitement about immunotherapy and the use of genetically engineered chimeric antigen receptor (CAR) T cells.

30 Sep 2016

Scientists find way to enhance, restore sensitivity to common treatment for breast cancer

Breast cancer is the most frequently diagnosed cancer among women, with estrogen-receptor-positive (ER+) being the most common type.

30 Sep 2016

X-ray laser-based technology enables faster structural analysis of receptor proteins

An international team of scientists has learnt how to determine the spatial structure of a protein obtained with an X-ray laser using the sulfur atoms it contains. This development is the next stage in the project of a group led by Vadim Cherezov to create an effective method of studying receptor proteins.

30 Sep 2016

Receptor News and Research

Combination treatment with CDK4/6 inhibitor improves progression-free survival in HR+ breast cancer patients

Study of pan-FGFR inhibitor uses mRNA in tumours to identify responders

Research reveals role of endoglin in shaping blood and cardiac cell fate during early development

Researchers explain why explain why some tumors recur after immunotherapy

No added benefit proven for pulmonary arterial hypertension drug, IQWiG finds

TUM scientists shed new light on metastases in the liver at early stage of pancreatic cancer

Study finds neoadjuvant immunotherapy safe, viable for early lung cancer patients before surgery

BUSM researchers identify new therapeutic target for treating compulsive binge eating

Researchers identify new strategy to selectively sensitize cancer cells to radiation therapy

Fruit flies shed light on how insulin signaling processes may be altered by diabetes in humans

Can vitamin D reduce asthma attacks? An interview with Professor Adrian Martineau

Blocking production of key receptor may reduce effects of cigarette smoke toxicity, study finds

Antibody protection may help control infection caused by TB bacteria

Inhibiting single protein could help restore sensitivity to common treatment for breast cancer

New study reveals CAR T cells can function as micro-pharmacies for precise therapeutic delivery

Scientists find way to enhance, restore sensitivity to common treatment for breast cancer

X-ray laser-based technology enables faster structural analysis of receptor proteins

TUM scientists discover molecular mechanism responsible for liver metastases at early stage

Immunotherapy already in clinical trials for cancer could slow progression of Parkinson's disease

Ki67 may help spare some breast cancer patients from sentinel lymph node biopsies

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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