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New study identifies PDGFRα as key molecule for HCMV viral entry

A publication in the scientific journal Nature Microbiology identifies PDGFRα as the receptor for the trimeric gHgLgO complex of Human cytomegalovirus (HCMV).

7 Jun 2016

Antiinflammatory drug HUMIRA enhances specific TNF function in rheumatoid arthritis patients

Researchers from University College London have discovered that the widely used antiinflammatory drug HUMIRA doesn't just work by inhibiting its target protein, TNF, but by enhancing a particular function of TNF in rheumatoid arthritis patients.

7 Jun 2016

Clinical study shows improved outcomes for NET patients treated with Lutathera over Octreotide LAR

NETTER-1 study, showing clinically meaningful and significant results for Lutathera (77Lu-DOTA0-Tyr3-Octreotate) in patients with metastatic midgut neuroendocrine tumors (NETs). The data will be presented Monday, June 6, during the American Society of Clinical Oncology Annual Meeting in Chicago.

6 Jun 2016

Improved research tool may open door to effective HIV vaccine designs

Vaccines are usually medicine's best defense against the world's deadliest microbes. However, HIV is so mutable that it has so far effectively evaded both the human immune system and scientists' attempts to make an effective vaccine to protect against it.

6 Jun 2016

IQWiG examines whether ramucirumab drug offers added benefit for MCRC and NSCLC patients

Ramucirumab is a monoclonal antibody, which blocks a receptor, reducing the growth of blood vessels and so reducing blood supply to the tumours.

6 Jun 2016

Novel drug atezolizumab harnesses immune system to shrink tumors in advanced bladder cancer

A new drug that harnesses the immune system to attack tumors is highly effective against advanced bladder cancer, according to the results of an international clinical trial to be presented June 5 at the annual meeting of the American Society for Clinical Oncology.

6 Jun 2016

Researchers prove existence of olfactory receptor in pigment-producing skin cells

Researchers at Ruhr-Universität Bochum were the first ones to prove the existence of an olfactory receptor in pigment-producing cells in human skin, the so-called melanocytes. The team headed by Prof Dr Dr Dr habil. Hanns Hatt demonstrated that the violet-like scent Beta-Ionone can activate the receptor.

4 Jun 2016

Study provides insight to gene shuffling process

Use of a new technique developed at the Babraham Institute has allowed researchers to take an in-depth look at the gene shuffling process that is responsible for our body's ability to recognise a vast range of foreign agents such as disease-causing microorganisms.

4 Jun 2016

UZH scientists identify new class of protein compounds to treat HER2-positive breast cancer

In Switzerland alone, more than 5,700 women are diagnosed with breast cancer each year, and almost 1,400 of those affected die of the disease. In many very invasive forms of breast cancer, the cells have too much of the receptor HER2 on their surface.

3 Jun 2016

Lower quantities of CD74 protein in placentas of preeclamptic women can impact fetal development

Preeclampsia is one of the most common complications to occur during pregnancy, yet its causes are still unknown. A new study involving patients, cell cultures and animal experiments has now shown that those affected by the disease have lower quantities of the placenta's immune protein CD74, and that certain inflammatory factors are higher. These factors disrupt the formation of the placenta and leave the fetus undernourished.

3 Jun 2016

DRD2 expression plays crucial role in protecting mice against kidney injury, hypertension

Dopamine signaling in the kidneys plays a critical role in blood pressure regulation and is responsible for nearly half of the salt and water excretion that occurs in response to increased dietary salt intake. Notably, genetic deletion of any of the 5 dopamine receptors expressed in the kidney causes hypertension in mice.

3 Jun 2016

New mouse model allows researchers to evaluate CD40-antibody drugs effectively

Cancer immunotherapies--drugs that work by making a patient's immune system better at spotting and destroying tumor cells--are increasingly generating headlines. A number of these drugs are now being used for the treatment of melanoma, lung, and kidney cancers, and are showing promise in clinical trials with other diseases as well.

3 Jun 2016

Advanced imaging kit Netspot gets FDA approval to detect rare neuroendocrine tumors

The U.S. Food and Drug Administration today approved Netspot, the first kit for the preparation of gallium Ga 68 dotatate injection, a radioactive diagnostic agent for positron emission tomography (PET) imaging.

2 Jun 2016

New technique could help reduce chances of drug failure during later stages of clinical trials

An approach that could reduce the chances of drugs failing during the later stages of clinical trials has been demonstrated by a collaboration between the University of Cambridge and pharmaceutical company GlaxoSmithKline.

2 Jun 2016

FDA approves blood-based cobas EGFR Mutation Test v2 for NSCLC patients

The U.S. Food and Drug Administration today approved the cobas EGFR Mutation Test v2, a blood-based companion diagnostic for the cancer drug Tarceva (erlotinib). This is the first FDA-approved, blood-based genetic test that can detect epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer patients.

2 Jun 2016

Denosumab drug that inhibits RANKL gene can prevent genetic breast cancer

An international team led by researchers at the Austrian Institute of Molecular Biotechnology in Vienna and the University of Maryland School of Medicine in Baltimore discovered that genetically determined breast cancer can be largely prevented by blocking a bone gene. An already approved drug could be quickly available and would then be the first breast cancer prevention drug.

1 Jun 2016

Understanding how opiates affect brain pathways to drive addiction cycle

New research by Steven Laviolette's research team at Western University is contributing to a better understanding of the ways opiate-class drugs modify brain circuits to drive the addiction cycle.

1 Jun 2016

Ocaliva drug gets FDA approval for primary biliary cholangitis treatment

On Friday, May 27, the U.S. Food and Drug Administration granted accelerated approval for Ocaliva (obeticholic acid) for the treatment of primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA, or as a single therapy in adults unable to tolerate UDCA.

1 Jun 2016

Study provides new insights into molecular basis of CaSR-related human diseases

A study led by researchers at Georgia State University provides new insights into the molecular basis of human diseases resulting from mutations in the calcium-sensing receptor (CaSR), a protein found in cell membranes.

1 Jun 2016

Researchers design ProAgio protein that may potentially treat cancer, other illnesses

A protein designed by researchers at Georgia State University can effectively target a cell surface receptor linked to a number of diseases, showing potential as a therapeutic treatment for an array of illnesses, including cancer, according to the research team.

1 Jun 2016

Receptor News and Research

New study identifies PDGFRα as key molecule for HCMV viral entry

Antiinflammatory drug HUMIRA enhances specific TNF function in rheumatoid arthritis patients

Clinical study shows improved outcomes for NET patients treated with Lutathera over Octreotide LAR

Improved research tool may open door to effective HIV vaccine designs

IQWiG examines whether ramucirumab drug offers added benefit for MCRC and NSCLC patients

Novel drug atezolizumab harnesses immune system to shrink tumors in advanced bladder cancer

Researchers prove existence of olfactory receptor in pigment-producing skin cells

Study provides insight to gene shuffling process

UZH scientists identify new class of protein compounds to treat HER2-positive breast cancer

Lower quantities of CD74 protein in placentas of preeclamptic women can impact fetal development

DRD2 expression plays crucial role in protecting mice against kidney injury, hypertension

New mouse model allows researchers to evaluate CD40-antibody drugs effectively

Advanced imaging kit Netspot gets FDA approval to detect rare neuroendocrine tumors

New technique could help reduce chances of drug failure during later stages of clinical trials

FDA approves blood-based cobas EGFR Mutation Test v2 for NSCLC patients

Denosumab drug that inhibits RANKL gene can prevent genetic breast cancer

Understanding how opiates affect brain pathways to drive addiction cycle

Ocaliva drug gets FDA approval for primary biliary cholangitis treatment

Study provides new insights into molecular basis of CaSR-related human diseases

Researchers design ProAgio protein that may potentially treat cancer, other illnesses

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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