Renal disease News and Research

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Diabetes medication reduces risk of heart failure hospitalization

In the largest trial to date to assess cardiovascular outcomes for an important class of diabetes medications, researchers have found that dapagliflozin markedly reduced the risk of hospitalization for heart failure in a broad population of patients with diabetes.

12 Nov 2018

New study does not support hypertensive effect from urate elevation

A study from a group of Massachusetts General Hospital investigators may reduce the concern that elevating levels of urate, an approach being investigated to treat several neurodegenerative disorders, could increase the risk of hypertension.

8 Nov 2018

AstraZeneca to present Phase III CVOT DECLARE-TIMI 58 results at AHA Scientific Sessions

AstraZeneca will present 20 abstracts including a late-breaking oral presentation on the full results from the Phase III cardiovascular outcomes trial DECLARE -TIMI 58, the broadest SGLT2 inhibitor CVOT conducted to date, as well as new research from the Company's Cardiovascular, Renal & Metabolism therapy area at the American Heart Association Scientific Sessions, November 10-12, 2018, in Chicago, Illinois, USA.

1 Nov 2018

$Preclinical studies show differences in healing responses to fractured and intact stent implanted in healthy, disease models$

Preclinical studies show differences in healing responses to fractured and intact stent implanted in healthy, disease models

CBSET, a non-for-profit preclinical research institute dedicated to biomedical research, education and advancement of medical technologies, announced today that its scientists have published data and analyses ("Fracture in drug-eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery") that "illustrate differences in the dynamic healing responses to fractured and intact stent implanted in healthy and disease rabbit models."

30 Oct 2018

Study finds link between Medicaid expansion and lower death rates among dialysis patients

In the first three years of Medicaid expansion due to the Affordable Care Act, the number of patients with end-stage kidney disease who died within a year of starting dialysis decreased in states that expanded Medicaid compared to non-expansion states, new research found.

25 Oct 2018

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

AstraZeneca and Merck & Co., Inc., Kenilworth, N.J., today announced detailed results from the Phase III SOLO-1 trial testing LYNPARZA (olaparib) 300 mg tablets twice-daily as a maintenance treatment for patients with newly diagnosed advanced BRCA-mutated ovarian cancer who were in complete or partial response following 1st-line standard platinum-based chemotherapy.

22 Oct 2018

Muscle mass plays a critical role in health, shows research

Adults go to the doctor roughly three times a year. During their visit, vitals are taken such as blood pressure, pulse, and weight, but are these measurements really showing the full picture of a person's overall health?

19 Oct 2018

New pragmatic study launched to understand the effectiveness of new type 2 diabetes drug

HealthCore, Inc., the outcomes research subsidiary of Anthem, Inc. and Novo Nordisk Inc., which manufacturers the once weekly GLP-1 receptor agonist Ozempic (semaglutide), are working together to launch the first of its kind pragmatic study to understand the benefits of semaglutide as compared with all other available diabetes drugs in a real-world pragmatic clinical trial for Type 2 diabetes - one of the nation's fastest growing chronic diseases.

17 Oct 2018

Dartmouth researchers receive grant to study acute kidney injury

Over two million people in the United States undergo cardiac catheterization each year. While the procedure is used effectively for both diagnostic and interventional purposes, it is not without risk: Acute kidney injury (AKI) occurs in up to 14 percent of all patients following a cardiac catheterization and up to 50 percent in patients with pre-existing kidney disease.

11 Oct 2018

Experts call for more transparency about joint-venture ownership of dialysis clinics

Penn Medicine experts in nephrology and health policy call for more transparency about joint-venture ownership of dialysis clinics to better understand what impact these arrangements may have on patient referrals and clinical outcomes.

4 Oct 2018

FARXIGA receives positive results in Phase III DECLARE-TIMI 58 cardiovascular outcomes trial

AstraZeneca today announced positive results from the Phase III DECLARE-TIMI 58 cardiovascular outcomes trial for FARXIGA, the broadest SGLT-2 inhibitor CVOT conducted to date.

24 Sep 2018

People with acute critical illness have increased risk of kidney complications and death

Acute critical illness in people without previous renal disease puts them at risk of kidney complications as well as death, according to a study in published in CMAJ

10 Sep 2018

Biologic, environmental factors may be possible culprits for racial disparities in CKD progression

Although black and Hispanic veterans with chronic kidney disease are more likely than white patients to see a kidney specialist- a nephrologist- they are more likely to suffer disease progression from early stage to advanced kidney disease, reports a study published this month in the Journal of the American Society of Nephrology from researchers at the Perelman School of Medicine at the University of Pennsylvania.

24 Aug 2018

Kidney transplant chains save more lives than kidney exchanges, shows research

New research from the UBC Sauder School of the Business has found that transplant societies which prioritize kidney transplant chains over kidney exchanges can increase the total number of transplants, thereby saving more lives.

10 Aug 2018

Otsuka’s JINARC approved for treatment of patients with CKD stage 4 ADPKD

Otsuka Pharmaceutical Europe Ltd. today announced that the European Commission has approved an extension of indication for JINARC to include adult patients with CKD stage 4 Autosomal Dominant Polycystic Kidney Disease

2 Aug 2018

Captozyme begins cross-over study of Nephure oxalate reducing enzyme

Captozyme, Inc. announced today that it is initiating a prospective double-blind, randomized, placebo controlled, cross-over study, with Nephure, an oxalate reducing enzyme, to determine the extent to which Nephure vs. placebo reduces urinary oxalate excretion (mg/24 hour) in healthy subjects who are provided a controlled diet.

12 Jul 2018

Scoring system based on PIRO helps predict mortality in surgical ICU patients with severe sepsis

A new classification system that scores the variables associated with mortality rates for patients who develop intra-abdominal sepsis after surgery may help guide care and improve outcomes

2 Jul 2018

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that Japan's Pharmaceuticals and Medical Devices Agency has approved LYNPARZA tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 -negative breast cancer who have received prior chemotherapy.

2 Jul 2018

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today new positive results from its Phase 1/2 study with lumasiran, an investigational RNAi therapeutic targeting glycolate oxidase for the treatment of Primary Hyperoxaluria Type 1.

8 Jun 2018

New study examines living kidney donors' concerns on kidney removal

In a new study that examined living kidney donors' concerns about their decision to undergo kidney removal, long-term kidney health, aspects of surgery and recovery, and impacts on life satisfaction were among those that donors felt were most important.

1 Jun 2018