Restenosis News and Research

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Restenosis means the reoccurrence of stenosis, a narrowing of a blood vessel, leading to restricted blood flow. Restenosis usually pertains to an artery or other large blood vessel that has become narrowed, received treatment to clear the blockage and subsequently become renarrowed. This is usually restenosis of an artery, or other blood vessel, or possibly a vessel within an organ.

Drug-eluting better than bare metal stents in diabetics

Drug-eluting stents reduced the risk of revascularization, heart attack and death in diabetics as compared with bare-metal stents in the largest observational comparison, researchers reported at the American Heart Association's Scientific Sessions 2008.

11 Nov 2008

Hispanics less likely to have repeat revascularizations 1 year after angioplasty

Hispanic patients were 57 percent less likely than Caucasian patients to undergo coronary artery bypass surgery (CABG) one year after successful angioplasty, a type of percutaneous coronary intervention (PCI) to open blockages in the coronary arteries.

10 Nov 2008

Dermatitis management

Although the variety of substances that can cause contact dermatitis is almost limitless, it often can be effectively managed with the proper diagnosis and treatment according to investigators presenting the latest research at the annual meeting of the American College of Allergy, Asthma and Immunology (ACAAI) in Seattle.

7 Nov 2008

The role played by drug-eluting stents in reducing acute myocardial infarction

The safety debate about drug-eluting stents (DES) is still ongoing. In these times of uncertainty about DES safety, the study has shown that DES markedly improve long-term survival compared to modern bare-metal stents (BMS) implantation in patients with acute ST-segment elevation myocardial infarction (STEMI). In our four year investigation, DES demonstrated a significant reduction of mortality in this sick patient subset.

2 Sep 2008

New generation drug-eluting stent demonstrates equivalent efficacy to market leader in 'real world'

In the first study of its kind, a drug-eluting stent (DES) with a biodegradable polymer applied only to the outer surface has been demonstrated as safe and effective as one of the most established and widely used types of DES with a durable polymer, in equivalent conditions to everyday clinical practice.

1 Sep 2008

Drug eluting stents: New elements in the debate

Results announced at the 2006 ESC meeting in Barcelona questioned the long-term safety of drug eluting stents (DES) and sparked intense discussion.

31 Aug 2008

Best use of drug-eluting stents: When should they be avoided?

Compared with bare metal stents, drug-eluting stents substantially reduce the risk of angiographic and clinical recurrence but do not affect mortality or the short term or long term risk of myocardial infarction.

31 Aug 2008

DES in diabetic patients

The issue of using or not using DES in patients with diabetes will be debated between Professor Wijns, who discourages DES and Professor Silber, who feels that they should be used.

31 Aug 2008

Drug-releasing coronary artery stent use linked with decrease in procedures to unblock coronary arteries

The widespread adoption of the use of drug-releasing coronary artery stents into routine practice is associated with a decrease in the need for repeat procedures to unblock coronary arteries and also do not appear to increase the risk of death, compared to bare-metal stents, according to a study in the June 25 issue of JAMA, the Journal of the American Medical Association

24 Jun 2008

New way to limit gene transfer and expression

Researchers from Northwestern University and Texas A & M University have discovered a new way to limit gene transfer and expression to specific tissues in animals.

23 Jun 2008

Drug-releasing stent shows promise for improving outcomes in patients with coronary artery disease

For patients who underwent angioplasty to open narrowed coronary arteries, the use of stents releasing the drug everolimus reduced the rate of renarrowing of the arteries and significantly reduced the risk of major cardiac events, compared to the widely-used paclitaxel-releasing stents, according to a study in the April 23/30 issue of JAMA, the Journal of the American Medical Association.

22 Apr 2008

Disappointing resuts for pimecrolimus, investigational anti-restenosis drug

A new medication that researchers had hoped would reduce the risk of arterial renarrowing after stenting has turned in a disappointing performance in a multicenter clinical trial, but the multi-reservoir stent that was used to deliver the drug is still considered promising.

1 Apr 2008

Study gives nod to drug-eluting stents in heart attack

Although drug-eluting stents have become widely used for the treatment of stable coronary artery disease, many cardiologists choose bare-metal stents for patients with heart attack, or myocardial infarction (MI), citing conflicting data about the safety and effectiveness of drug-eluting stents in this patient group.

31 Mar 2008

Drug-eluting stents outperform bare-metal stents

New evidence from a large randomized study is answering important questions about the best approach to percutaneous coronary intervention (PCI) in patients with a type of heart attack known as ST-segment-elevation myocardial infarction (STEMI).

31 Mar 2008

FDA approves Endeavor Zotarolimus-eluting coronary stent

The U.S. Food and Drug Administration has approved the Endeavor Zotarolimus-Eluting Coronary Stent for use in treating patients with narrowed coronary arteries, the blood vessels supplying the heart.

5 Feb 2008

Drug eluting stents should be used with caution in acute myocardial infarction

Drug-eluting stents are extremely effective devices to prevent restenosis following angioplasty. Yet, since last year, there is some debate and persistent uncertainty regarding the long term safety of these devices. Specifically, there is concern that some of these stents may occlude abruptly more than 1 year after placement, due to "late stent thrombosis".

3 Sep 2007

Left main stem angioplasty

The left main coronary artery supplies at least two thirds of the hearts blood supply. When it becomes narrowed it causes large areas of the heart to malfunction with subsequent severe anginal chest pain and breathlessness. Occlusion of the left main coronary is usually fatal within a matter of seconds.

3 Sep 2007

The burden of diabetes in heart disease in Europe

Diabetes is becoming one of the major health problems in the European and US populations. It is frequently associated with overweight, hypertension and high serum cholesterol levels, representing a dangerous combination of risk factors for the development of heart and vascular diseases.

2 Sep 2007

Australian researchers discover a 'novel molecular dictator with a conscience'

University of New South Wales (UNSW) researchers have uncovered an important naturally occurring mechanism in the body where "bad" cells that cause blockages in our blood vessels are kept under strict growth control, while "good" cells that keep our blood vessels free of clots and growths are left unaffected.

27 Aug 2007