Restless Legs Syndrome News and Research

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Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and an uncontrollable urge to move when at rest in an effort to relieve these feelings. RLS sensations are often described by people as burning, creeping, tugging, or like insects crawling inside the legs. Often called paresthesias (abnormal sensations) or dysesthesias (unpleasant abnormal sensations), the sensations range in severity from uncomfortable to irritating to painful.

The most distinctive or unusual aspect of the condition is that lying down and trying to relax activates the symptoms. As a result, most people with RLS have difficulty falling asleep and staying asleep. Left untreated, the condition causes exhaustion and daytime fatigue. Many people with RLS report that their job, personal relations, and activities of daily living are strongly affected as a result of their exhaustion. They are often unable to concentrate, have impaired memory, or fail to accomplish daily tasks.
XenoPort receives grant from Michael J. Fox Foundation to support Parkinson's disease therapies

XenoPort receives grant from Michael J. Fox Foundation to support Parkinson's disease therapies

XenoPort third quarter net loss decreases to $19.9 million

XenoPort third quarter net loss decreases to $19.9 million

FDA reviews GSK's response to Complete Response letter for Horizant

FDA reviews GSK's response to Complete Response letter for Horizant

People hospitalized after stroke on a weekend more likely to die: Study

People hospitalized after stroke on a weekend more likely to die: Study

Study suggests treating RLS may improve sleep and quality of life in people with fibromyalgia

Study suggests treating RLS may improve sleep and quality of life in people with fibromyalgia

XenoPort to present XP23829 preclinical data at ECTRIMS meeting

XenoPort to present XP23829 preclinical data at ECTRIMS meeting

New video PSA may help raise donation for brain research

New video PSA may help raise donation for brain research

Neupro improves quality of life in Parkinson's disease patients

Neupro improves quality of life in Parkinson's disease patients

Research shows dexamethasone treatment effective for bacterial meningitis

Research shows dexamethasone treatment effective for bacterial meningitis

XenoPort to present XP21279 clinical trial data at World Parkinson Congress meeting

XenoPort to present XP21279 clinical trial data at World Parkinson Congress meeting

XenoPort intends to initiate Phase 3 XP19986 trial for multiple sclerosis

XenoPort intends to initiate Phase 3 XP19986 trial for multiple sclerosis

XenoPort announces equity award to new employee under 2010 Inducement Plan

XenoPort announces equity award to new employee under 2010 Inducement Plan

Overweight, smoking and lack of exercise linked to frequent headaches in teens

Overweight, smoking and lack of exercise linked to frequent headaches in teens

Study finds lithium drugs not effective for amyotrophic lateral sclerosis treatment

Study finds lithium drugs not effective for amyotrophic lateral sclerosis treatment

Jazz Pharmaceuticals second-quarter net product sales increase 49% to $39.5 million

Jazz Pharmaceuticals second-quarter net product sales increase 49% to $39.5 million

Rotigotine provides clinically relevant improvements in RLS symptoms: Study

Rotigotine provides clinically relevant improvements in RLS symptoms: Study

REM sleep behavior disorder may later lead to neurologic disorders

REM sleep behavior disorder may later lead to neurologic disorders

Preclinical data of new acamprosate prodrug to be presented at International Fragile X Conference

Preclinical data of new acamprosate prodrug to be presented at International Fragile X Conference

GSK, XenoPort disappointed with GSK1838262/XP13512 phase 2b study for migraine headaches

GSK, XenoPort disappointed with GSK1838262/XP13512 phase 2b study for migraine headaches

New research identifies memory and brain scan as best tests for predicting Alzheimer's disease

New research identifies memory and brain scan as best tests for predicting Alzheimer's disease