Retinal tissue may degenerate for a number of reasons. Among them are: artery or vein occlusion, diabetic retinopathy, R.L.F./R.O.P. or disease (usually hereditary). Retinitis pigmentosa, retinoschisis, lattic degeneration, and macular degeneration are characterized by progressive types of retinal degeneration.
Ocugen, Inc., a clinical-stage company focused on discovering, developing and commercializing transformative therapies to treat rare and underserved ophthalmic diseases, announced today the publication in Nature Gene Therapy of preclinical data of nuclear hormone receptor gene NR2E3 as a genetic modifier and therapeutic agent to treat multiple retinal degenerative diseases.
Professor Stéphane Lefrançois, a researcher at the Institut National de la Recherche Scientifique (INRS), is working on Batten disease, a neurodegenerative genetic disease that primarily affects children. His research focuses on the most common form of the disease - Batten CLN 3 - which is caused by mutations in the protein of the same name and for which there is still no cure.
Scientists from Trinity College Dublin have made an important discovery with implications for those living with a common, debilitating eye disease (age-related macular degeneration, AMD) that can cause blindness.
Mice born blind have shown significant improvement in vision after undergoing a new gene therapy developed by a team of Japanese scientists.
UPMC has implanted the first patient in the United States with a new wireless retinal device as part of a clinical trial aimed at restoring partial sight to patients with advanced age-related macular degeneration, a disease that leads to permanent blindness.
A new study published today by researchers from Baylor College of Medicine and UT Health's McGovern Medical School in the Proceedings of the National Academy of Sciences reveals an unprecedented close-up view of cilia linked to blindness.
A new study involving the fruit fly, Drosophila melanogaster, published in the journal npj Aging and Mechanisms of Disease, shows that when flies are kept in darkness, or in white light from which the blue spectrum has been excluded, they live longer, compared to flies kept in alternating 12-hour shifts of blue LED light and darkness. The reason appears to be a speeded-up version of aging; the brain cells, retinal cells and climbing ability, all suffer a breakdown.
Combining two different treatment methods to slow the progression of myopia may deliver better results than either can achieve on their own.
In experiments with rats, pigs and monkeys, Johns Hopkins Medicine researchers have developed a way to deliver sight-saving gene therapy to the retina.
Genes borrowed from a spider turned Peter Parker into Spiderman. If scientists can use archaea--tiny organisms similar to bacteria--as a source of useful genes for humans, might it help prevent blindness one day?
Three unrelated families on three continents (from continental Portugal, the United States and Brazil), all with healthy ancestors, had children with a very rare disease.
More than a year after becoming one of the first medical institutions nationally to complete a revolutionary gene replacement surgery to restore vision in patients with retinal degeneration, surgeons at the of The Vision Center at Children's Hospital Los Angeles have successfully completed the procedure on an additional 13 patients.
Researchers have found that the complement system seems to protect against retinal degeneration in retinitis pigmentosa.
The scientific research team from the Universidad Pablo de Olavide led by doctor José Antonio Sánchez Alcázar has published a new study in the international magazines Molecular Neorubiology and Neural Regeneration Research.
Eye research charity, Fight for Sight, is funding the development of an ‘organ-on-chip’ that for the first time will be used to help investigate glaucoma, a leading cause of blindness.
It was surprisingly simple. University of California, Berkeley, scientists inserted a gene for a green-light receptor into the eyes of blind mice and, a month later, they were navigating around obstacles as easily as mice with no vision problems.
Millions of Americans are progressively losing their sight as cells in their eyes deteriorate, but a new therapy developed by researchers at the University of California, Berkeley, could help prolong useful vision and delay total blindness.
How is a healthy retina cell like a tumor cell? It hijacks an energy-producing chemical reaction to churn out molecular building blocks. When tumor cells do it, they use the building blocks to make cancer grow and spread. But when retina cells do it, they renew photoreceptor membranes that keep our vision sharp.
Retinal dystrophies such as Age-related macular degeneration (AMD) are a major cause of vision loss in aging populations. National Eye Institute (NEI) estimates that the prevalence of advanced AMD will grow to nearly 3 million by 2020.
A signaling pathway controlled by transforming growth factor beta (TGF-beta) could be involved in the progression of age-related macular degeneration.