Retinal tissue may degenerate for a number of reasons. Among them are: artery or vein occlusion, diabetic retinopathy, R.L.F./R.O.P. or disease (usually hereditary). Retinitis pigmentosa, retinoschisis, lattic degeneration, and macular degeneration are characterized by progressive types of retinal degeneration.
New UCLA research in mice suggests that "dormant" cone photoreceptors in the degenerating retina are not dormant at all, but continue to function, producing responses to light and driving retinal activity for vision.
Researchers observe corneal damage by blue light exposure is due to PI3K/AKT pathway inhibition.
Those with Usher Syndrome -- the leading hereditary cause for simultaneous deafness and blindness, for which there is no treatment -- may have a new reason for hope now that researchers have confirmed the first-ever nonhuman primate model of their disease.
Oregon State University College of Pharmacy scientists have demonstrated in animal models the possibility of using lipid nanoparticles and messenger RNA, the technology underpinning COVID-19 vaccines, to treat blindness associated with a rare genetic condition.
Visual cells in the human retina may not simply die in some diseases, but are mechanically transported out of the retina beforehand.
An enzyme called Fic, whose biochemical role was discovered at UT Southwestern more than a dozen years ago, appears to play a crucial part in guiding the cellular response to stress, a new study suggests.
Researchers from the National Eye Institute have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Leber congenital amaurosis (LCA), a disease that causes blindness in early childhood.
A new study provides insights into the novel mechanisms through which blue light exposure interferes with non-retinal cell metabolic pathways in flies.
In this interview, News-Medical speaks to Xinxing Zhang, a postdoctoral research fellow at the University of Michigan, about his research investigating vision loss in Bardet-Biedl syndrome.
Researchers have identified distinct differences among the cells comprising a tissue in the retina that is vital to human visual perception.
In the search for eternal youth, poo transplants may seem like an unlikely way to reverse the aging process.
Researchers demonstrated ocular tropism of SARS-CoV-2 through neuronal invasion in transgenic mice with hACE2 expression.
A team of researchers at Baylor College of Medicine and collaborating institutions has shed new light into the complexity of vitamin B12 diseases.
Inherited retinal degeneration can make even the most mundane tasks-;like cooking, driving and walking down the sidewalk-;difficult or impossible, and it can't be cured.
Scientists have discovered that gene therapy and the diabetes drug metformin may be potential treatments for late-onset retinal degeneration (L-ORD), a rare, blinding eye disease.
HyVIS, the European project coordinated by the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology), is about to start.
A novel computational platform developed by researchers from the University of Pittsburgh School of Medicine identifies top-performing viral vectors that could deliver gene therapies to the retina with maximum efficiency and precision.
Can coronavirus disease 2019 (COVID-19) affect the eye? New research suggests the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter the eye and infect photoreceptor and retinal ganglion cells. In addition, SARS-CoV-2 infection increases the expression of several inflammatory genes, including the cytokine interleukin 33 (IL33), which is linked to COVID-19 disease and retinal degeneration.
Nanoscope Technologies LLC, a biotechnology company developing gene therapies for treatment of retinal diseases, is featuring multiple scientific presentations highlighting its groundbreaking research on optical gene delivery for vision restoration and OCT-guided electrophysiology platforms for characterization of retinal degeneration and assessment of efficacy of cell-gene therapy at the 2021 ARVO annual (virtual) meeting, May 1-7.
An analysis of thousands of genomes from people with and without the rare eye disease known as MacTel has turned up more than a dozen gene variants that are likely causing the condition to develop and worsen for a significant share of patients.