Retinal tissue may degenerate for a number of reasons. Among them are: artery or vein occlusion, diabetic retinopathy, R.L.F./R.O.P. or disease (usually hereditary). Retinitis pigmentosa, retinoschisis, lattic degeneration, and macular degeneration are characterized by progressive types of retinal degeneration.
Researchers who made a knock-in mouse-model of the genetic disorder retinitis pigmentosa 59, or RP59, expected to see retinal degeneration and retinal thinning. As reported in the journal Cells, they surprisingly found none, calling into question the commonly accepted -- though never proved -- mechanism for RP59.
Santen Pharmaceutical Co., Ltd. and jCyte Inc. announced the conclusion of an exclusive licensing contract covering the development, registration and commercialisation rights in Japan, Asia and Europe to jCell, a first-in-class investigational therapy, currently in clinical development for retinitis pigmentosa.
The Nanoscope team has developed Multi-Characteristic Opsins to sensitize cells toward low level of white light so that vision is improved at ambient room light.
Multi-disciplinary work led by researchers from Trinity College Dublin has pinpointed a potential new therapeutic target for treating retinal degeneration. The work has discovered that a protein (SARM1) involved in neuronal cell injury may also have a role in the progression of retinal degeneration.
Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision.
Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors for vision.
Ocugen, Inc., a clinical-stage company focused on discovering, developing and commercializing transformative therapies to treat rare and underserved ophthalmic diseases, announced today the publication in Nature Gene Therapy of preclinical data of nuclear hormone receptor gene NR2E3 as a genetic modifier and therapeutic agent to treat multiple retinal degenerative diseases.
Professor Stéphane Lefrançois, a researcher at the Institut National de la Recherche Scientifique (INRS), is working on Batten disease, a neurodegenerative genetic disease that primarily affects children. His research focuses on the most common form of the disease - Batten CLN 3 - which is caused by mutations in the protein of the same name and for which there is still no cure.
Scientists from Trinity College Dublin have made an important discovery with implications for those living with a common, debilitating eye disease (age-related macular degeneration, AMD) that can cause blindness.
Mice born blind have shown significant improvement in vision after undergoing a new gene therapy developed by a team of Japanese scientists.
UPMC has implanted the first patient in the United States with a new wireless retinal device as part of a clinical trial aimed at restoring partial sight to patients with advanced age-related macular degeneration, a disease that leads to permanent blindness.
A new study published today by researchers from Baylor College of Medicine and UT Health's McGovern Medical School in the Proceedings of the National Academy of Sciences reveals an unprecedented close-up view of cilia linked to blindness.
A new study involving the fruit fly, Drosophila melanogaster, published in the journal npj Aging and Mechanisms of Disease, shows that when flies are kept in darkness, or in white light from which the blue spectrum has been excluded, they live longer, compared to flies kept in alternating 12-hour shifts of blue LED light and darkness. The reason appears to be a speeded-up version of aging; the brain cells, retinal cells and climbing ability, all suffer a breakdown.
Combining two different treatment methods to slow the progression of myopia may deliver better results than either can achieve on their own.
In experiments with rats, pigs and monkeys, Johns Hopkins Medicine researchers have developed a way to deliver sight-saving gene therapy to the retina.
Genes borrowed from a spider turned Peter Parker into Spiderman. If scientists can use archaea--tiny organisms similar to bacteria--as a source of useful genes for humans, might it help prevent blindness one day?
Three unrelated families on three continents (from continental Portugal, the United States and Brazil), all with healthy ancestors, had children with a very rare disease.
More than a year after becoming one of the first medical institutions nationally to complete a revolutionary gene replacement surgery to restore vision in patients with retinal degeneration, surgeons at the of The Vision Center at Children's Hospital Los Angeles have successfully completed the procedure on an additional 13 patients.
Researchers have found that the complement system seems to protect against retinal degeneration in retinitis pigmentosa.
The scientific research team from the Universidad Pablo de Olavide led by doctor José Antonio Sánchez Alcázar has published a new study in the international magazines Molecular Neorubiology and Neural Regeneration Research.