Ribonucleic Acid News and Research

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Study supports the concept of atherosclerosis as a T-cell autoimmune disease targeting the arterial wall

Researchers assessed T-cell tolerance checkpoints observed in atherosclerosis.

27 Feb 2023

Rebounding of COVID-19 symptoms and viral load are common among untreated COVID-19 patients

Researchers characterize COVID-19 symptom and viral load rebounds among untreated individuals with mild-to-moderate SARS-CoV-2 infection.

27 Feb 2023

Roadmap outlines a framework for moving COVID-19 vaccines forward

Researchers presented the coronavirus vaccines research and development roadmap to promote the development of broadly protective COVID-19 vaccines.

24 Feb 2023

Apolipoprotein E4 promotes the development of Alzheimer’s disease

Researchers characterize the effects of neuronal apolipoprotein E4 on Alzheimer’s disease-associated pathology.

23 Feb 2023

Is the advantage conferred by the heterologous regimen conserved after a booster dose of mRNA-based COVID-19 vaccine?

Researchers compared the efficacy of a third COVID-19 vaccine dose and that of homologous and heterologous regimens.

23 Feb 2023

CDC evaluation of the efficacy of monovalent mRNA vaccines in preventing symptomatic SARS-CoV-2 infection in 3 to 5-year-olds

The complete primary series monovalent mRNA vaccines protect children aged three to five against symptomatic infection for up to four months.

22 Feb 2023

CDC provides vaccine efficacy estimates of Pfizer and Moderna vaccines in kids ages 3-5

Vaccination coverage among infants and children varied according to age, race and ethnicity, jurisdiction, and rural and urban settings

22 Feb 2023

Study reports that depleting gut bacteria in mice with genetic risk for AD reduces neuropathology in a sex-dependent manner

Researchers highlight recent research investigating whether gut microbiota regulates tau pathology and tau-mediated neurodegeneration in an ApoE isoform–dependent manner.

21 Feb 2023

Researchers report the circulation of a novel MERS-like coronavirus in Malayan pangolins

Researchers reported the circulation of a novel MERS-like coronavirus among Malayan pangolins, Manis javanica HKU4-associated CoV (MjHKU4r-CoV).

21 Feb 2023

Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread

Researchers mapped Zika virus infections in the lymph nodes to determine how the Zika virus enters from different points in the skin and disseminates through the body.

20 Feb 2023

In-depth assessment of muscle biopsies in patients with long COVID

Researchers analyzed skeletal muscle biopsies of patients with persistent fatigue and malaise post-exertion to determine the underlying mechanisms of long COVID.

20 Feb 2023

Genome editing prevents hypertrophic cardiomyopathy in mice

In a recent study published in the journal PLoS Digital Health, researchers pursued one-time cures for hypertrophic cardiomyopathy (HCM). They used a previously constructed murine model of HCM, designated as R403Q-129SvEv, to evaluate two different genetic therapies, as follows:

19 Feb 2023

How effective has the bivalent booster COVID vaccination been?

In a recent study published in the journal Eurosurveillance, researchers estimated the effectiveness of bivalent messenger ribonucleic acid (mRNA) vaccines targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 subvariant and the original Wuhan-Hu1 strain against Omicron infections in the vaccinated population of the Netherlands between 26 September and 19 December 2022.

19 Feb 2023

Gut dysbiosis and sepsis susceptibility among pregnant women

Researchers describe the role of gut dysbiosis during pregnancy in promoting excessive macrophage pyroptosis, which increases vulnerability to sepsis.

19 Feb 2023

Research reports full efficacy of Sotrovimab against BQ.1.1 viral replication in a non-human primate challenge model

Researchers used a non-human primate model to show that Sotrovimab, a commercial mAb also known as Xevudy, was fully effective against SARS-CoV-2 Omicron BA.5 sub-lineage and its derivatives, such as BQ.1.1.

17 Feb 2023

Cohort study examines the incidence of SARS-CoV-2 rebound in patients on oral antivirals

Researchers performed a retrospective population-wide cohort study using anonymized data in Hong Kong, China, between February 26 and July 3, 2022.

16 Feb 2023

Delayed presentation of MIS-C following COVID-19

Researchers elucidate the pathophysiology of MIS-C and describe the probable reasons for the delayed presentation of the condition following COVID-19.

15 Feb 2023

Comparative study on retinoic acid-inducible gene-I of humans and bats

In a recent study posted to the bioRxiv* preprint server, researchers cloned and functionally characterized the virus ribonucleic acid (RNA) sensor, retinoic acid-inducible gene-I (RIG-I), from the microbat Myotis daubentonii (Yangochiroptera suborder) and the megabat Rousettus aegyptiacus (Yinpterochiroptera suborder), and compared them to the human ortholog.

15 Feb 2023

Jamaican fruit bat's response to SARS-CoV-2 adapted to human

In a recent study posted to the bioRxiv* server, researchers examined the vulnerability of Jamaican fruit bats (Artibeus jamaicensis) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

15 Feb 2023

Study finds a new mammalian antiviral response pathway restricting poxviruses replication

In a recent study posted to the bioRxiv* preprint server, researchers identified a novel antiviral pathway different from the interferon (IFN) pathway that inhibited poxvirus(es) replication.

15 Feb 2023

Ribonucleic Acid News and Research

Study supports the concept of atherosclerosis as a T-cell autoimmune disease targeting the arterial wall

Rebounding of COVID-19 symptoms and viral load are common among untreated COVID-19 patients

Roadmap outlines a framework for moving COVID-19 vaccines forward

Apolipoprotein E4 promotes the development of Alzheimer’s disease

Is the advantage conferred by the heterologous regimen conserved after a booster dose of mRNA-based COVID-19 vaccine?

CDC evaluation of the efficacy of monovalent mRNA vaccines in preventing symptomatic SARS-CoV-2 infection in 3 to 5-year-olds

CDC provides vaccine efficacy estimates of Pfizer and Moderna vaccines in kids ages 3-5

Study reports that depleting gut bacteria in mice with genetic risk for AD reduces neuropathology in a sex-dependent manner

Researchers report the circulation of a novel MERS-like coronavirus in Malayan pangolins

Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread

In-depth assessment of muscle biopsies in patients with long COVID

Genome editing prevents hypertrophic cardiomyopathy in mice

How effective has the bivalent booster COVID vaccination been?

Gut dysbiosis and sepsis susceptibility among pregnant women

Research reports full efficacy of Sotrovimab against BQ.1.1 viral replication in a non-human primate challenge model

Cohort study examines the incidence of SARS-CoV-2 rebound in patients on oral antivirals

Delayed presentation of MIS-C following COVID-19

Comparative study on retinoic acid-inducible gene-I of humans and bats

Jamaican fruit bat's response to SARS-CoV-2 adapted to human

Study finds a new mammalian antiviral response pathway restricting poxviruses replication

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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