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Safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent booster mRNA-1273.222

Researchers evaluated the immunogenicity and safety of the COVID-19 bivalent mRNA vaccine mRNA-1273.222 and tested the neutralizing ability of the two bivalent vaccines — mRNA-1273.222 and mRNA-1273.214 — against the newly emergent Omicron subvariants.

19 Dec 2022

Study uncovers genetic cause of a novel developmental epilepsy syndrome

Neurodevelopmental disorders (NDD) encompass highly prevalent conditions such as autism and epilepsy, with cognitive disabilities alone affecting 1-3% of the global population.

16 Dec 2022

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

Researchers investigated the cellular tropism, replication competence, persistence and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, and associated histopathological changes in infected tissues.

16 Dec 2022

Study finds anti-S binding antibody levels are a valid correlate of protection against Omicron BA.1/BA.2 infections

Researchers used serological measurements from a longitudinal cohort to evaluate the use of binding antibodies against the SARS-CoV-2 spike protein receptor binding domain as correlates of protection against the immune evasive Omicron subvariants BA.1 and BA.2.

16 Dec 2022

SARS-CoV-2 Omicron BQ and XBB subvariants show exceptional immune evasion properties

Researchers demonstrated the exceptional immune evasion properties of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants, BQ and XBB.

16 Dec 2022

Scientists identify a novel epitope at the SARS-CoV-2 spike furin cleavage site

Scientists identify an immunogenic epitope at the furin cleavage site of the SARS-CoV-2 spike protein.

15 Dec 2022

What influence has COVID-19 vaccination had on sperm characteristics?

Researchers assessed the influence of coronavirus disease 2019 (COVID-19) vaccination on sperm characteristics.

15 Dec 2022

Study assesses COVID-19 booster vaccination coverage by demographics and behaviors and experiences toward vaccination among fully vaccinated adults

An early release from the CDC, USA, examines the coverage of booster doses among adults in the USA.

15 Dec 2022

Research reveals that a viral toxin may contribute to the severity of COVID-19

Researchers determine whether the SARS-CoV-2 spike protein influences endothelial and epithelial barrier dysfunction and vascular leakage.

14 Dec 2022

The debilitating effects of long-COVID in the U.S.

A new study posted to the preprint server medRxiv* discusses chronic disability due to long COVID in the United States.

14 Dec 2022

What is the relation between COVID-19 vaccination and new POTS-related diagnoses?

Researchers assessed the association between POTS and SARS-CoV-2 infections and COVID-19 vaccinations.

14 Dec 2022

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Researchers isolated SARS-CoV-2 spike protein-targeted mAbs from convalescent healthcare workers, emphasizing the IGHV1-69 gene, the gene with the greatest structural and allelic variation.

14 Dec 2022

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

In a recent study posted to the medRxiv* preprint server, researchers in Australia and Switzerland evaluated the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in community-based settings of the United States (US).

13 Dec 2022

Researchers identify molecular determinants of post-infection long-COVID

In a recent study published in the journal Nature Medicine, researchers presented a transcriptome-wide assessment of blood gene expression changes that occur in acute COVID-19 (coronavirus disease 2019) and are associated with PASC (post-acute sequelae of COVID-19), commonly known as long-COVID.

13 Dec 2022

Overview of current methods, technologies, and applications in the molecular diagnosis of mpox

Researchers provided an overview of existing molecular methods for mpox virus detection.

13 Dec 2022

Study suggests persistent inflammatory response triggered by SARS-CoV-2 may be responsible for observed sequelae in PASC patients

Researchers assessed the association of enhanced migratory or activated CD8+ T cell and reduced avidity reactive cellular response due to post-acute COVID-19 syndrome (PASC).

13 Dec 2022

Ribonucleic Acid News and Research

Safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent booster mRNA-1273.222

Study uncovers genetic cause of a novel developmental epilepsy syndrome

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

Study finds anti-S binding antibody levels are a valid correlate of protection against Omicron BA.1/BA.2 infections

SARS-CoV-2 Omicron BQ and XBB subvariants show exceptional immune evasion properties

Scientists identify a novel epitope at the SARS-CoV-2 spike furin cleavage site

What influence has COVID-19 vaccination had on sperm characteristics?

Study assesses COVID-19 booster vaccination coverage by demographics and behaviors and experiences toward vaccination among fully vaccinated adults

Research reveals that a viral toxin may contribute to the severity of COVID-19

The debilitating effects of long-COVID in the U.S.

What is the relation between COVID-19 vaccination and new POTS-related diagnoses?

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

Researchers identify molecular determinants of post-infection long-COVID

Overview of current methods, technologies, and applications in the molecular diagnosis of mpox

Study suggests persistent inflammatory response triggered by SARS-CoV-2 may be responsible for observed sequelae in PASC patients

Scientists use single-cell multi-omics data to map disease regulatory circuits

XBB Omicron variant evades vaccine-induced immunity

Study shows emerging Omicron sublineages efficiently evade neutralization independent of immunization history

Severe COVID-19 causes aging-like changes in the human brain

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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