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Prime-pull immunization of mice with novel subunit vaccine elicits mucosal immunity to prevent severe SARS CoV-2 infection

Prime-pull immunization of mice with novel subunit vaccine elicits mucosal immunity to prevent severe SARS CoV-2 infection

Researchers tested whether a subunit vaccine could generate mucosal immunity in mice and prevent SARS-CoV-2 infection and related pathology.

11 Apr 2022

New research on SARS-CoV-2 Omicron variant mutations and sotrovimab therapy

New research on SARS-CoV-2 Omicron variant mutations and sotrovimab therapy

A recent study posted to the medRxiv* preprint server assessed the impact of sotrovimab treatment on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-infected immunocompromised (IC) patients.

11 Apr 2022

Immunocompromised hosts with Delta/Omicron co-infections

Immunocompromised hosts with Delta/Omicron co-infections

A recent study posted to the medRxiv* preprint server examined clinical cases of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta/Omicron variants and Omicron BA.1/ BA.2 sublineages in immunocompromised (IC) patients.

10 Apr 2022

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

In a recent article published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers reviewed the present-day therapeutic landscape of coronavirus disease 2019 (COVID-19) and addressed future opportunities to overcome challenges that hinder drug development and improve the global preparedness for future pandemics.

10 Apr 2022

The effect of unsuppressed HIV on T-cell response to COVID-19

The effect of unsuppressed HIV on T-cell response to COVID-19

A new study evaluates the impact of HIV infection on SARS-CoV-2 T-cell responses during the first and second waves of COVID-19 in South Africa.

10 Apr 2022

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

Researchers assess the impact of interval administration of LD-IL-2 was examined in 18 T1D patients who received a three-day dosing interval.

10 Apr 2022

CDC report on Omicron infections soon after Delta

CDC report on Omicron infections soon after Delta

A new study identifies ten patients with confirmed SARS-CoV-2 Omicron variant infections within 90 days of a previous Delta variant infection.

10 Apr 2022

Study explores the antibody evasion pattern of SARS-CoV-2 Omicron sublineages

Study explores the antibody evasion pattern of SARS-CoV-2 Omicron sublineages

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8 Apr 2022

Improved seroprevalence and antibody response after third COVID-19 vaccination

Improved seroprevalence and antibody response after third COVID-19 vaccination

Researchers evaluated the immunogenicity of a third COVID-19 vaccination in antibody deficient subjects.

8 Apr 2022

Exploring SARS-CoV-2 detection by profiling micro RNAs

Exploring SARS-CoV-2 detection by profiling micro RNAs

A new study analyzed the micro ribonucleic acid profiles in nasal swabs collected from COVID-19 patients.

8 Apr 2022

SARS-CoV-2 detected using smartphone biosensor

SARS-CoV-2 detected using smartphone biosensor

Researchers describe the use of RT-LAMP in combination with particle diffusometry to detect SARS-CoV2 in saliva samples.

7 Apr 2022

Researchers assess prevalence of SARS-CoV-2 reinfections

Researchers assess prevalence of SARS-CoV-2 reinfections

Researchers assessed the prevalence of SARS-CoV-2 reinfections in the Province of Modena, Italy.

7 Apr 2022

Efficacy of SARS-CoV-2 hyperimmune globulin in treatment of severely immunocompromised hospitalized COVID-19 patients

Efficacy of SARS-CoV-2 hyperimmune globulin in treatment of severely immunocompromised hospitalized COVID-19 patients

Researchers conducted a controlled, double-blinded Phase III trial to evaluate the efficacy of SARS-CoV-2) hyperimmune globulin in immunocompromised hospitalized COVID-19 patients.

7 Apr 2022

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

A recent article presented the diverse pathogenesis of SARS-CoV-2 variants of concern in a humanized mouse model.

7 Apr 2022

Transcriptional reprogramming of monocytes in COVID-19

Transcriptional reprogramming of monocytes in COVID-19

In a recent study posted to the bioRxiv* server, researchers examined the functionality of cluster of differentiation 14-positive (CD14+) monocytes in patients with mild or moderate coronavirus disease 2019 (COVID-19).

7 Apr 2022

An assessment of COVID-19 vaccine safety during pregnancy

An assessment of COVID-19 vaccine safety during pregnancy

In a recent study posted to the Preprints with The Lancet* SSRN preprint server, researchers evaluated the safety of currently administered coronavirus disease 2019 (COVID-19) vaccines in child-bearing women.

7 Apr 2022

How effective are mRNA boosters against to Delta and Omicron?

How effective are mRNA boosters against to Delta and Omicron?

The current study discusses available data on the effectiveness of mRNA vaccination against Omicron.

6 Apr 2022

Evaluating clinical and economic impact of varying COVID-19 booster effectiveness in the US

Evaluating clinical and economic impact of varying COVID-19 booster effectiveness in the US

Researchers used an economic model to project the differences in the clinical and economic impact of mRNA-1273 and BNT162b2 booster vaccines among the adult population of the US.

6 Apr 2022

Investigating high rate of Omicron sublineage breakthrough infections in triple vaccinated healthcare workers

Investigating high rate of Omicron sublineage breakthrough infections in triple vaccinated healthcare workers

Researchers identified breakthrough infections by Omicron sublineages BA.1, BA.1.1, and BA.2 in triple-vaccinated healthcare workers of Sweden.

6 Apr 2022

Researchers explore the link between immunoglobulins and blood profile in severe SARS-CoV-2 patients

A new study illustrated the association of immunoglobulins with blood characteristics in COVID-19 patients.

6 Apr 2022

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